Ke PENG

Title: Priciple Investigator E-mail: pengke@wh.iov.cn

Education

2002, B.S. College of Life Sciences and Technology, Huazhong Agricultural University

2012, Ph.D. Department of Virology, Wageningen University, The Netherlands (KNAW-CAS)



Research Interests
Viruses regulate and remodel cellular system and micro-environment to facilitate efficient viral replication, to evade host sensing and to control the fate of an infected cell. Understanding these manipulation strategies employed by viruses provide opportunities to develop antivirals to intervene viral infection. In our group, we use several OMICs technologies to screen host factors that are regulated by viral infection and have direct association with viral proteins. Modern imaging technologies will then be applied to monitor the selected virus-host interactions in live and in situ. Complementary functional analysis will be employed to investigate the functional mechanisms involved in different stages of viral replication. HIV-1 and emerging bunyaviruses (SFTSV, RVFV, CCHFV, etc) are the model viruses that we are currently studying.


Publications

1) Ke Peng*, David Bejarano, Vibor Laketa, K. Laurence Jost, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich* (2017) CPSF6 promotes HIV-1 nuclear entry and viral infectivity in human primary macrophage

Revision

2) Ke Peng, Walter Muranyi, Bärbel Glass, Vibor Laketa, Stephen R Yant, Luong Tsai, Tomas Cihlar, Barbara Müller, Hans-Georg Kräusslich (2014) Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid eLIFE 2014;3:e04114

3) Ke Peng, Jan W. M. van Lent, Sjef Boeren, Minggang Fang, David A. Theilmann, Martin A. Erlandson, Just M. Vlak and Monique M. van Oers (2012) Characterization of novel components of the baculovirus per os infectivity factor complex Journal of Virology vol. 86 no. 9, p.4981-4988

4) Ke Peng, Jan W. M. van Lent, Just M. Vlak, Zhihong Hu and Monique M. van Oers (2011) In situ cleavage of the baculovirus occlusion-derived virus receptor binding protein P74 in the per os infectivity complex Journal of Virology vol. 85 no. 20, p. 10710-10718

5) Ke Peng, Monique M. van Oers, Zhihong Hu, Jan W. M. van Lent and Just M. Vlak (2010) Baculovirus per os infectivity factors form a complex on the surface of occlusion-derived virus Journal of Virology vol.84 no.18, p. 9497-9504

6) Ke Peng, Minzhi Wu, Fei Deng, Jingjiao Song, Chunsheng Dong, Hualin Wang and Zhihong Hu (2010) Identification of protein–protein interactions of the occlusion-derived virus-associated proteins of Helicoverpa armigera nucleopolyhedrovirus Journal of General Virology vol.91 no 3, p. 659-670