Title: Principle Investigator E-mail:


1998-2001 Ph.D. Immunology. Department of Viral Genetics & Immunology, Institute of Virology, Chinese Center of Disease Control (Chinese CDC, National Academy of Preventive Medicine), Beijing, China.

1995-1998 MSc. Lanzhou Medical School, University of Lanzhou, China.

1991-1995 BSc. Department of Biology, Northwest Normal University, China.

Research Interests


1.    Li W, Xiao J, Zhou X, Xu M, Hu C, Xu X, Lu Y, Liu C, Xue S, Nie L, Zhang H, Li Z, Zhang Y, Ji F, Hui L, Tao W, Wei B*, Wang H*.STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.J Clin Invest. 2015 Nov 2;125(11):4239-54.(IF:13.7)

2.    Chen J, Han L, Xu X, Tang H, Wang H, Wei B*. Serum biomarkers VEGF-C and IL-6 are associated with severe human Peripheral Artery Stenosis. J Inflamm (Lond). 2015 Aug 18;12:50. IF2.7

3.    Li CY, Xiao J, Jiao SZ, Sheng Chun, Leng QB, Rudd CE, Wei B*, Wang H*.  ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Mol Med, 2015, Apr 7;7(6):754-69 (IF: 8.2)

4.    Zhang YB, Lu Y, Ma L, Li DS, He YL, Wei B*,Wang H*. VEGFR-3 restrains TLR4-NF-κB triggered inflammation and protects from endotoxin shock. Immunity, 2014, 40; 1-14. ( IF:21.56

5.    Zhang Y, Liu C, Wei B*, Pei G. Loss of β-Arrestin 2 exacerbates experimental autoimmune encephalomyelitis and impairs differentiation of Foxp3+CD4+ regulatory T cells. Immunology. 2013 Dec;140(4):430-40. IF:3.735

6.    Wei B*, Pei G. microRNAs: critical regulators in TH17 cells and players in diseases. Cell Mol Immunol. 2010 May; 7(3):175-81.IF:4.185

7.    Wei B*#, Chapman S, Wieckiewicz J, Wood KJ*. IFN-γ triggered JAK-STAT-1-AKT signaling pathway influences the function of alloreactive regulatory T cells.  Am J Transplant. 2010 Jan; 10 (1):69-80.IF:6.19

8.    Wei B#, Lei H#, Abbink T, Groppelli E, Gao W, Lim D, Thaker Y, Lever AM, Jolly C, Wang H*, Rudd CE*. Adhesion and degranulation-promoting adaptor protein (ADAP) and the ADAP-SLP-76 module regulate HIV-1 cell-cell spread and replication in T-cells. Retrovirology. 2013 Sep 18;10(1):101.IF: 4.767

9.    Li J#, Wei B#, Guo A, Liu C, Huang SC, Du F, Fan W, Bao CD, Pei G*. Deficiency of -arrestin1 ameliorates the development of rheumatoid arthritis with impaired TH17 cell differentiation. PNAS 2013, 110 (18):7395–7400.IF:9.808

10.  Wei B#, da Rocha Dias S, Wang H, Rudd CE*. TcR-CTLA-4 Co-ligation induced rapid polarization that depends on phosphatidylinositol 3-Kinase, Vav-1, Cdc42 and myosin light chain kinase. J Immunol, 2007, 179: 400-408. IF:5.362

11.  Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, Zhang S, Chen P, Wu ZY, Ding J, Hu R, Wei B,Wang H. LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 2017 Jan; 214(1): 209-226. (IF:13.9

12.  Huang S*, Mao J, Wei B, Pei G. The anti-spasticity drug baclofen alleviates collagen-induced arthritis and regulates dendritic cells. J Cell Physio, 2015 Jan 3. ( IF:4.218

13.  Li C, Jiao S, Wang G, Gao Y, Liu C, He X, Zhang C, Xiao J, Li W, Zhang G, Wei B, Chen H, Wang H. The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection. PLoS Pathog. 2015 Apr 24;11(4):e1004824. IF8.05

14.  Li H, Yue R, Wei B, Gao G, Du J, Pei G*. Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis. EMBO J. 2014 Jun 17;33(12):1383-96. ( IF:10.748

15.  Yue R#, Li H#, Liu H, Li YY, Wei B, Gao G, Liu TX, Wei L, Du JL, Pei G*. Thrombin receptor signaling regulates endothelial to haematopoietic transition. Developmental Cell. 2012 May 15; 22 (5):1092-100.IF:10.366

16.  Chen T#, Yuan D#, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G*. E-cadherin-Mediated Cell-Cell Contact is Critical for Induced Pluripotent Stem Cell Generation. Stem Cells. 2010 Jun 2. 28:13151325. IF:7.133

17.  Cao N, Liu Z, Chen Z, Wang J, Chen TT, Zhao X, Ma Y, Qin L, Kang JH, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells promoting the proliferation of cardiac progenitor cells. Cell Research. 2012 Jan;22(1):219-36.IF:11.981

18.  Gog J R,  Murcia A, Osterman N, Restif O, McKinley T J, Sheppard M, Achouri S, Wei B, Mastroeni P, Wood JL, Maskell DJ, Cicuta P, Bryant CE*. Dynamics of Salmonella infection of macrophages at the single cell level. J R Soc Interface. 2012 Oct 7;9(75):2696-707.IF:3.856

19.  Wang H. Wei B, Bismuth G, Rudd CE*. ADAP-SLP-76 binding integrates TcR/LFA-1 signals to regulate calcium mobilization for T-cell spreading and IL-2 amplification. PNAS. 2009 Jul 28;106 (30):12436-41.IF:9.808

20.  Walsh C, Gangloff M, Monie T, Smyth T, Wei B, McKinley TJ, Maskell D, Gay NJ and Bryant CE*, Elucidation of the MD-2/TLR4 interface required for signaling by Lipid IVa. J Immunol. 2008 Jul 15;181(2):1245-54. IF:5.362

21.  Wood KJ*, Feng G, Wei B, Sawitzki B, Bushell AR. Interferon gamma: Friend or foe? Transplantation. 2007 Jul 15; 84: S4-5. IF:3.535

22.  Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE*. Reversal of the TCR stop signal by CTLA-4. Science. 2006 Sep 29; 313 (5795):1972-5. IF:31.477

23.  Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE*. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. PNAS. 2005 Sep 6;102 (36):12861-6. IF:9.808