Wuxiang GUAN

Title: Principle Investigator E-mail: guanwx@wh.iov.cn

Education

Dr. Guan obtained his BSc in Clinical Medicine (2000) and MSc in Virology (2003) from Tongji Medical University. His PhD was awarded by Institute of Viral Disease Control and Prevention, Chinese CDC (2006).



Research Interests

Dr. Guan did research in University of Kansas Medical Center (2007-2009), in Stowers Institute of Medical Research (2010-2012) before joining WIV in 2012. His research focuses on understanding the mechanism of DNA replication of virus, alternative polyadenylation regulation of viral mRNA and 3’ end biogenesis of noncoding RNA.



Publications

J Biol Chem. 2011.Internal polyadenylation of the parvovirus B19 precursor mRNA is regulated by alternative splicing.

J Virol. 2011.Inclusion of the Central Exon of Parvovirus B19 Precursor mRNA is Determined by Multiple Splicing Enhancers both in the Exon and the Downstream Intron.Role of erythropoietin receptor signaling in parvovirus B19 replication in human erythroid progenitor cells.

Virol J.2010. Interactions of SARS coronavirus nucleocapsid protein with the host cell proteasome subunit p42.

Blood. 2010.The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells.

Virology. 2009.Molecular characterization of human parvovirus B19 genotypes 2 and 3.

J Virol. 2009.The genome of human parvovirus b19 can replicate in nonpermissive cells with the help of adenovirus genes and produces infectious virus.

J Virol. 2009.Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses.

J Virol. 2008.Block to the production of full-length B19 virus transcripts by internal polyadenylation is overcome by replication of the viral genome.

J Virol Methods.2008.ELISAs using human bocavirus VP2 virus-like particles for detection of antibodies against HBoV.