Bo ZHANG

Title: Principle Investigator E-mail: zhangbo@wh.iov.cn

Education

2002.02 – 2005.11, PhD, Institute for Medical Molecular Biology, University of Luebeck, Germany;  Major: Molecular biology and virology 

1998.09 – 2001.06, MS, Department of Microbiology, College of Life Sciences, Shandong University, China; Major: Microbiology

1994.09 – 1998.06, BS, Department of Microbiology, College of Life Sciences, Shandong University, China; Major: Microbiology Engineering



Research Interests

Prof. Zhang is interested in the replication mechanisms of positive single-stranded RNA viruses, and aims to understand viral pathogenesis and to help for antiviral therapy and vaccine. Specifically, the major focus is arthropod-borne flaviviruses (JEV, DENV) and alphavirus (CHIKV). To establish a complete reverse genetic system is a prerequisite for the study of these viruses. Using these systems, we devote to studying the functions of viral structural and nonstructural proteins during viral infection. Reverse genetic tools for JEV, DENV2, CHIKV, YFV, EV71 and CA16 have been successfully established in my laboratory. He has published over 60 papers in the field of virology and obtained 5 Chinese patents.



Publications

J Virol. 2016. Transmembrane Domains of NS2B Contribute to Both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus. 

Virol Sin. 2016. Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells. 

J Virol. 2014. Inhibition of enterovirus 71 by adenosine analog NITD008. 

J Virol. 2013. Crystal structure of Enterovirus 71 RNA-Dependent RNA Polymerase complexed with Its Protein Primer VPg: Implication for a trans Mechanism of VPg Uridylylation.

J Virol. 2012. Enterovirus 71 VPg Uridylation Uses a Two-Molecular Mechanism of 3D Polymerase.