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Biao Yu
Highest Education  
  345 Lingling Road, Shanghai
Zip Code  

Education and Appointments:
1999.12–present: Professor; 1997.9–2000.11: Associate Professor; 1996.9–1997.8: Assistant Professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 1995.9–1996.8: Postdoc, Dept. of Chemistry, New York University 1992-1995: Ph.D. in Organic Chemistry; 1989-1992: M.S. in Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 1985-1989: B.S. in Nuclear Chemistry, Peking University

Research Interest:
Total Synthesis, Synthetic Methodology, and Chemical Biology of biologically significant oligosaccharides, glycoconjugates, and other natural products, especially the glycosaminoglycans of mammal, antibiotics of microbe, glycosides of plants and marine species. And Chemistry of the Traditional Chinese Medicine.
Public Services:

1997: ‘Award for Invention’ (2nd class), Chinese Academy of Sciences 1998: ‘Young Chemist Award’, Chinese Chemical Society 1998-1999: ‘Outstanding Young Researcher’, Shanghai 1999: ‘Meiji Life Science Award’, Meiji Co., Shanghai 1999,2002: ‘Rising Star (Grant)’, The Science and Technology Committee of Shanghai 2000: ‘Outstanding Young (Grant)’, The National Natural Science Foundation of China 2000: ‘Servier Young Investigator Awards in Medicinal Chemistry’, Chinese Pharmacological Society 2000: ‘Outstanding Young’, Chinese Academy of Sciences 2003: ‘Hundreds Talents (Grant)’, Chinese Academy of Sciences 2004: ‘Outstanding Scholar’, Shanghai 2004: ‘Candidates of the National Talents’, China 2006: ‘Award for Natural Sciences’ (2nd class), Shanghai 2007: ‘Research Award for Life Chemistry’, WuXi Pharma Tech
Selected Publication:
1. Total synthesis of Lobatoside E, a potent antitumor cyclic triterpene saponin. C. Zhu, P. Tang, B. Yu,* J. Am. Chem. Soc. 2008, 130, 5872-5873.
2. Gold(I) catalyzed glycosidation of 1,2-anhydrosugars. Y. Li, P. Tang, Y. Chen, B. Yu,* J. Org. Chem. 2008, 73, 4323-4325.
3. Synthesis of Betavulgaroside III, a representative triterpene seco-glycoside. S. Zhu, Y. Li, B. Yu,* J. Org. Chem. 2008, 73, 4978-4985.
4. An efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph3PAuOTf. Y. Li, Y. Yang, B. Yu,* Tetrahedron Lett. 2008, 49, 3604-3608.
5. Synthesis of a tetrasaccharide substrate of heparanase. J. Chen, Y. Zhou, C. Chen, W. Xu, B. Yu,* Carbohydr. Res. 2008, 343, 2853-2862.
6. Total synthesis of Candicanoside A, a potent antitumor saponin bearing a rearranged steroid side chain. P. Tang, B. Yu,* Angew. Chem. Int. Ed. 2007, 46, 2527-2530.
7. The cytotoxicity of saponins correlates with their cellular internalization. Y. Wang, Y. Zhang, B. Yu,* ChemMedChem 2007, 2, 888-291.
8. Carbohydrate chemistry in the total synthesis of saponins. B. Yu,* Y. Zhang, P. Tang, Eur. J. Org. Chem. 2007, 5145-5161.
9. Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue. M. Li, B. Yu,* Org. Lett. 2006, 8, 2679-2682.
10. Total synthesis of CRM646-A and B, two fungal glucuronides with potent heparinase inhibition activities. P. Wang, Z. Zhang, B. Yu,* J. Org. Chem. 2005, 70, 8884-9.
11. Synthesis of Anemoclemoside B, the first natural product with an open-chain cyclic acetal glycosidic linkage. J. Sun, X. Han, B. Yu,* Org. Lett. 2005, 7, 1935-1938.
12. 23-Oxa-analogues of OSW-1: efficient synthesis and extremely potent antitumor activity. B. Shi, H. Wu, B. Yu,* J. Wu, Angew. Chem. Int. Ed. 2004, 43, 4324-4327.
13. Efficient sialylation with phenyltrifluoroacetimidate as leaving groups. S. Cai, B. Yu,* Org. Lett. 2003, 5, 3827-3830.
14. Facial synthesis of flavonoid 7-O-glycosides. M. Li, X. Han, B. Yu,* J. Org. Chem. 2003, 68, 6842-6845.
15. Total synthesis of the antiallergic naphtho-alpha-pyrone tetraglucoside, cassiaside C2, isolated from cassia seeds. Z. Zhang, B. Yu,* J. Org. Chem. 2003, 68, 6309-6313.
16. Glycosyl trifluoroacetimidates. 2. Synthesis of dioscin and xiebai saponin I.  B. Yu,* H. Tao, J. Org. Chem. 2002, 67, 9099-9102.
17. Efficient synthesis of the hexasaccharide fragment of Landomycin A: Using phenyl 2,3-O-thionocarbonyl-1-thio-glycosides as 2-deoxy-beta-glycoside precursors. B. Yu,* P. Wang, Org. Lett. 2002, 4, 1919-1922.
18. A double random strategy for the synthesis of saponin libraries. B. Yu,* B. Li, G. Xing, Y. Hui,* J. Comb. Chem. 2001, 3, 404-406.
19. Stereoselective synthesis of 2-S-phenyl-2-deoxy--glycosides using phenyl 2,3-O-thionocarbonyl-1-thio-glycoside donors via 1,2-migration and concurrent glycosidation. B. Yu,* Z. Yang, Org. Lett. 2001, 3, 377-379.
20. Glycosyl trifluoroacetimidates. Part I. Preparation and application as new glycosyl donors. B. Yu,* H. Tao, Tetrahedron Lett. 2001, 42, 2405-2407.
21. First synthesis of a bidesmosidic triterpene saponin by a highly efficient procedure. B. Yu,* J. Xie, S. Deng, Y. Hui,* J. Am. Chem. Soc. 1999, 121, 12196-12197.
22. First total synthesis of an exceptionally potent saponin, OSW-1. S. Deng, B. Yu,* Y. Lou, Y. Hui,* J. Org. Chem.  1999, 64, 202-208.
23.  First total synthesis of tricolorin A.  S. Lu, Q. Ouyang, Z. Guo, B. Yu,* Y.  Hui,* Angew. Chem.; Int. Engl. Ed.  1997, 36, 2344-2346.

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