刘景根 ----中国科学院上海药物研究所

机构概况

机构简介		所长致辞

现任领导		历任领导

学术委员会		学位委员会

组织机构		两院院士

历史沿革		园区风貌

历年年报		人才招聘

研究队伍

院士专家

研究组长

杰出青年

百人计划

千人计划

人才招聘

　您现在的位置：首页 > 研究队伍

研究队伍

姓名:	刘景根	性别:	男
职称:	研究员	学历:	博士
电话:	021-50807588	传真:
电子邮件:	jgliu@mail.shcnc.ac.cn	个人主页:
通讯地址:	上海市祖冲之路555号　201203

简历：

1996 年在中国药科大学获理学博士学位，专业神经药理学。后在军事医学科学院从事博士后研究工作。1998 年至 2003 年在美国阿肯色医科大学疼痛神经生物学实验室和药理毒理系阿片受体信号转导实验室从事研究工作。 2003 年 7 月应聘到中国科学院上海药物所工作。中国科学院“百人计划” 学者 , 2004 年获国家杰出青年科学基金。

研究方向：

主要从事阿片类药物耐受、成瘾的细胞和分子机理研究。

专家类别：

研究员；百人计划；杰青

职务：

中科院上海药物所研究员、博士生导师、研究组长

科研成果：

承担科研项目情况：

社会任职：

获奖及荣誉：

代表论著：

1. Xu C, Hong MH, Zhang LS, Hou YY, Wang FF, Chen YJ, Xu XJ, Chen J, Xie X, Ma L, Chi ZQ, Liu JG* (2010) Serine 363 Residue of δ-Opioid Receptor is Crucial for Adopting Distinct Pathways to Activate ERK1/2. J Cell Sci 123:4259-4270.

2. Lu G, Zhou QX, Kang S, Li QL, Zhao LC, Chen JD, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Xu L*, Liu JG * (2010) Chronic morphine treatment impaired hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 30: 5058-5070.

3. Hou YY, Lu B, Li M, Liu Y, Chen J, Chi ZQ, and Liu JG* (2009) Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine dependent rats. J Neurosci 29: 12244-12245.

4. Hong MH, Xu C, Wang YJ, Ji JL, Tao YM, Xu XJ, Chen J, Xie X, Zhi-Qiang Chi ZQ, Liu JG* (2009) Role of Src in Ligand-specific Regulation of δ-opioid Receptor Desensitization and Internalization. J Neurochem 108: 102-114.

5. Wang YJ, Tao YM, Xu XJ, Chen J, Cao YL, Chi ZQ, Liu JG*(2009) Pharmacological Characterization of ATPM-AZ, a Novel Mixed κ Agonist and μ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J Pharmacol Exp Ther 329: 306-313.

6. Lin X, Wang YJ, Huo YY, Li Q, Chi ZQ, Liu JG* (2009) Morphine promotes SH-SY5Y cell apoptosis through c-Jun N-terminal kinase-mediated activation of mitochondria-dependent apoptosis pathway. FEBS J 276: 2022-2036.

7. Lin X, Li Q, Wang YJ, Ju YW, Chi ZQ, Wang MW, Liu JG* (2007) Morphine Inhibits Doxorubicin-induced Reactive Oxygen Species Generation and Nuclear Factor-κB Transcriptional Activation in Neuroblastoma SH-SY5Y Cells. Biochem J 406: 215-221.

8. Wu ZQ, Chen J, Chi ZQ and Liu JG* (2007) Involvement of Dopamine System in Regulation of Na+,K+-ATPase in the Striatum upon Activation of Opioid Receptors by Morphine. Mol Pharmacol 71: 519-530.

9. Chen XL, Lu G, Gonh YX, Zhao LC, Chen J, Chi ZQ, Yang YM, Chen Z, Li QL, Chi ZQ, Liu JG* (2007) Involvement of changes in protein expression of hippocampal energy metabolism enzymes in behavioral abnormalities during chronic morphine treatments. Cell Res 17: 689-700.

10. Wu ZQ, Li M, Chen J, Chi ZQ and Liu JG* (2006) Involvement of cAMP/cAMP-Dependent Protein Kinase Signaling Pathway in Regulation of Na+,K+-ATPase upon Activation of Opioid Receptors by Morphine. Mol Pharmacol 69: 866-876.

11. Liu JG, Prather PL (2002) Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors. J Pharmacol Exp Ther 302: 1070-1079.

12. Liu JG, Ruckle MB, Prather PL (2001) Constitutively active μ-opioid receptors inhibits adenylyl cyclase activity in intact cells and activates G-proteins differently than the agonist DAMGO. J Biol Chem 276: 37779-37786.

13. Liu JG, Prather PL (2001) Chronic exposure to μ-opioid agonists produces constitutive activation of μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol 60: 53-62.

14. Liu JG, Anand KJS (2001). Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Res Rev38: 1-19.