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研究队伍
姓 名:
 　徐明华
性 别:
 　男
职 称:
 　研究员
学 历:
 　博士
电 话:
 　021-50807388
传 真:
 　
电子邮件:
 　xumh@mail.shcnc.ac.cn
个人主页:
 　
通讯地址:
 　上海市祖冲之路555号　201203
简历：
1999 年 7 月毕业于中国科学院上海有机化学研究所，获得理学博士学位；同年 8 月赴美国，先后在美国弗吉尼亚大学 ( University of Virginia ) 化学系和乔治城大学医学研究中心 ( Georgetown University Medical Center ) 从事 博士后工作研究。 2003 年 7 月底回国，先期受聘于中国科学院上海有机化学研究所，后入选中国科学院“百人计划”。 2005 年 7 月起 任中国科学院上海药物研究所研究员、课题组长。

研究方向：
主要从事有机不对称合成及有重要生理活性化合物的合成研究。

专家类别：
研究员；百人计划

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：

承担科研项目情况：
  1. 国家自然科学基金面上项目2010-2012  (20972172，主持)
  2. 上海市科技启明星跟踪 2008-2010  (08QH14027，主持)
  3. 国家自然科学基金创新群体项目 2008-2010  (20721003，子课题负责)
  4. 国家自然科学基金重点项目 2007-2010  (20632060，子课题负责)
  5. 国家自然科学基金面上项目2007-2009  (20672123，主持)
  6. 中国科学院百人计划项目2005-2009  (主持)

社会任职：

获奖及荣誉：
  1. 2005  中国化学会青年化学奖
  2. 2005  中国科学院“百人计划”
  3. 2005  上海市青年科技启明星
  4. 2006  JAPS Asian Core Program Lectureship Award (2007, Japan)
  5. 2007  药明康德生命化学研究奖（三等奖）
  6. 2007  JSPS Asian Core Program Lectureship Award (2008, Japan)
  7. 2008  中科院上海分院杰出青年科技创新人才提名奖
  8. 2008  上海市青年科技启明星后
  9. 2008  Asian Core Program Lectureship Award (2009, Singapore)

    应邀担任国际知名学术期刊J. Am. Chem. Soc., Org. Lett., J. Org. Chem., Chem. Commun., Tetrahedron, Tetrahedron Lett. 等的审稿人。

代表论著：

近期发表论文选录

  1. Bo Zhang, Ming-Hua Xu*, and Guo-Qiang Lin*, “Catalytic Enantioselective Synthesis of Chiral Phthalides by Efficient Reductive Cyclization of 2-Acylarylcarboxylates under Aqueous Transfer Hydrogenation Conditions”, Organic Letters 2009, 11, 4712-4715.
  2. Lei Chen, and Ming-Hua Xu*, “A New Approach to Pyrrolocoumarin Derivatives by Pd-Catalyzed Reactions: Expedient Construction of Polycyclic Lamellarin Scaffold”, Adv. Synth. Catal. 2009, 351, 2005-2012.
  3. Min Liu, Xing-Wen Sun, Ming-Hua Xu*, and Guo-Qiang Lin*, “Highly Efficient Asymmetric Synthesis of Vinylic Amino Alcohols by Zn-Promoted Benzoyloxyallylation of Chiral N-tert-Butanesulfinyl Imines: Facile and Rapid Access to (-)-Cytoxazone”, Chem. Eur. J. 2009, 15, 10217-10224.
  4. Du-Ming Ji, and Ming-Hua Xu*, “InBr3-Catalyzed Direct Alkynylation of Nitrones with Terminal Alkynes: an Efficient Synthesis of N-Hydroxy-propargyl Amines”, Tetrahedron Lett. 2009, 50, 2952-2955. (Highlighted by SYNFACTS, 2009, 7, 0775)
  5. Xing-Wen Sun, Ming-Hua Xu* and Guo-Qiang Lin*, “Rapid Assembly of anti-1,3-Diol Units with 2-Quaternary Carbon Stereocenter via Samarium Diiodide-Promoted Tandem Aldol/Evans-Tishchenko Reaction”, Tetrahedron Lett. 2009, 50, 3381-3384 (50th Anniversary Special Issue).
  6. Chen-Guo Feng, Zhi-Qian Wang, Cheng Shao, Ming-Hua Xu*, and Guo-Qiang Lin*, “Highly Practical Catalytic Asymmetric 1,4-Addition of Arylboronic Acids in Water Using New Hydrophilic Chiral Bicyclo[3.3.0] Diene Ligands”, Organic Letters 2008, 10, 4101-4104. (Highlighted by SYNFACTS, 2008, 11, 1181)
  7. Guo-Qiang Lin, Ming-Hua Xu, Yu-Wu Zhong and Xing-Wen Sun, “An Advance on Exploring N-tert-Butanesulfinyl -imines in Asymmetric Synthesis of Chiral Amines”, Acc. Chem. Res. 2008, 41, 831-840.
  8. Chen-Guo Feng, Zhi-Qian Wang, Ping Tian, Ming-Hua Xu*, and Guo-Qiang Lin*, “Easily Accessible C2-Symmetric Chiral Bicyclo[3.3.0] Dienes as Ligands for Rhodium-Catalyzed Asymmetric 1,4-Addition”, Chem. Asia. J. 2008, 3, 1511-1516. (Special Issue: In Honor of Professor Ryoji Noyori for His 70th Birthday)
  9. Xing-Wen Sun, Min Liu, Ming-Hua Xu*, and Guo-Qiang Lin*, “Remarkable Salt Effect on In-Mediated Allylation of N-tert-Butanesulfinyl Imines in Aqueous Media: Highly Practical Asymmetric Synthesis of Chiral Homoallylic Amines and Isoindolinones”, Organic Letters 2008, 10, 1259-1262. (Highlighted by SYNFACTS, 2008, 06, 0597; Abstracted by ChemInform, 2008, 39, 35-056)
  10. Zhi-Qian Wang, Chen-Guo Feng, Ming-Hua Xu*, and Guo-Qiang Lin*, “Design of C2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids”, J. Am. Chem. Soc. 2007, 129, 5336-5337. (Highlighted by SYNFACTS, 2007, 08, 0847 and Organic Chemistry Portal; Abstracted by ChemInform, 2007, 38, 37-073).
  11. Xing-Wen Sun, Ming-Hua Xu* and Guo-Qiang Lin*, “Room-Temperature Highly Diastereoselective Zn-Mediated Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled Stereoselectivity Reversal”, Organic Letters 2006, 8, 4979-4982. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Dec 4, 2006); also highlighted by SYNFACTS, 2006, 12, 1266).
  12. Yu-Wu Zhong, Yi-Zhou Dong, Kai Fang, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin*, “A Highly Efficient and Direct Approach for Synthesis of Enantiopure α-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes”, J. Am. Chem. Soc. 2005, 127, 11956-11957. (Highlighted by SYNFACTS, 2005, 3, 0331; Abstracted by ChemInform, 2005, 37, 01-088).
  13. Ling-Lin Huang, Ming-Hua Xu* and Guo-Qiang Lin, “A New Entry to Efficient Asymmetric Synthesis of Optically Active ,-Substituted -Butyrolactones Using Carbohydrate Derived Amide as both a Chiral Auxiliary and a Proton Source”, J. Org. Chem. 2005, 70, 529-532.
  14. Yu-Wu Zhong, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin, “Highly Diastereoselective and Enantioselective Synthesis of Enantiopure C2-Symmetrical Vicinal Diamines by Reductive Homocoupling of Chiral Aromatic N-tert-Butanesulfinyl Imines”, Organic Letters 2004, 6, 4747-4750.
  15. Yu-Wu Zhong, Ming-Hua Xu* and Guo-Qiang Lin, “Samarium Diiodide-Induced Asymmetric Synthesis of Optically Pure Unsymmetrical Vicinal Diamines by Reductive Cross-Coupling of Nitrones with N-tert-Butanesulfinyl Imines”, Organic Letters 2004, 6, 3953-3956. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Nov 15, 2004); also highlighted by Angew. Chem. Int. Ed. 2005, 44, 7833.).