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研究队伍
姓 名:
 　张翱
性 别:
 　男
职 称:
 　研究员
学 历:
 　博士
电 话:
 　021-50806035
传 真:
 　
电子邮件:
 　aozhang@mail.shcnc.ac.cn
个人主页:
 　
通讯地址:
 　上海市祖冲之路555号　201203
简历：

1988年9月至1992年7月，就读于西华师范大学化学系，获学士学位；1992年9月至1995年7月，就读于南开大学元素有机化学研究所，获硕士学位；1997年10月至2000年10月，中科院上海有机化学研究所，获博士学位，导师为姜标研究员。1995年7至1997年9月，在中科院上海有机化学研究所工作，任研究实习员。2001年2月至2002年3月，在美国乔治敦大学(Georgetown University)医药中心作博士后访问学者；2002年4月至2006年2月，在美国哈佛大学(Harvard University)医学院工作，任哈佛医学院 Instructor,McLean Hospital药物化学研究室Assistant Director,美国化学会东北分会会刊《The Nucleus》副编辑；2005年获中科院“百人计划”称号，2006年至今在中国科学院上海药物研究所工作，获中科院“百人计划”择优支持。2010年获中科院百人计划终期评估优秀奖，2011年获国家杰出青年基金。

研究方向：

张翱研究组主要从事创新药物研发及相关基础研究，尤其是靶向G-蛋白偶联受体（GPCR）和酪氨酸激酶（RTK）新型小分子药物的设计与合成研究。主要是通过发展新颖简捷合成方法实现类药性优势骨架的高效合成，以及基于活性天然产物类药性骨架进行多样性合成和衍生化，结合现代药物结构优化策略，探索药物的结构与活性、结构与靶向性、结构与成药性等规律，进而开发具有抗神经退行性疾病和抗肿瘤活性的新型药物。研究组目前正在进行的研究课题主要有：【1】具有抗肿瘤活性的类药性天然产物的合成及基于成药性的结构优化；【2】靶向酪氨酸激酶或DNG修复等特异性或多靶性抑制剂抗肿瘤药物的设计与合成；【3】靶向G-蛋白偶联受体小分子药物的设计及抗神经退行性疾病活性研究。

专家类别：
研究员；百人计划；国家杰出青年

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：

承担科研项目情况：

社会任职：

获奖及荣誉：

2004年获哈佛医学院McLean Hospital年度最高学术奖-A LFRED POPE AWARD；同年还获得哈佛医学院 McLean Hospital - ADAM CORNEEL YOUNG INVESTIGATOR AWARD；2010年获中科院“百人计划”终期评估优秀奖；2011年获国家杰出青年基金。

代表论著：

1、SELECTED PUBLICATIONS (2009-2011)

  1. Chengtang Du, Fulong Li, Xuefeng Zhang, Wenxiang Hu, Qizheng Yao, Ao Zhang. Lewis Acid-Catalyzed Cyclization of Glycals/2-deoxy-D-ribose with Aryl Amines: Additional Findings on Product Structure and Reaction Diastereoselectivity. J. Org. Chem. 2011, 76, 8833-8839.
  2. Jun Sun, Xuefeng Zhang, Fulong Li, Chunyong Ding, Wenjuan Wu, Ao Zhang. Base-promoted reaction of methyl 4,6-O-benzylidene-3-deoxy-hexopyranosid-2-ulose and various arylamines Tetrahedron Lett. 2011, 52, 5693-5696.
  3. Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors. Org. Biomol. Chem. 2011, 9, 5930-5933.
  4. Hai Zhang, Na Ye, Shanglin Zhou, Lin Guo, Longtai Zheng, Zhili Liu, Bo Gao, Xuechu Zhen, and Ao Zhang: Identification of N-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson's Agent Possessing a Dopamine D2 and Serotonin 5-HT1A Dual-Agonist Profile. J. Med. Chem. 2011, 54, 4324-4338.
  5. Ailing Zhao, Xin Gao, Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Meiyu Geng, Ao Zhang: Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold. Bioorg. Med. Chem. 2011, 19, 3906-3918.
  6. Zhiqing Liu, Qingzhang Zhu, Fuying Li, Lina Zhang, Ying Leng, Ao Zhang: N-(5-Substituted Thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) Propanamides as Glucokinase Activators. MedChemComm 2011, 2 (6), 531 - 535.
  7. Fulong Li, Chunyong Ding, Meining Wang, Qizheng Yao, Ao Zhang: InBr3-Catalyzed Glycosidation of Glycals with Arylamines: An Alternative Approach To Access 4-Aminocyclopent-2-enones. J. Org. Chem. 2011, 76, 2820–2827.
  8. Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng, Ao Zhang: Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri- substituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)- 5-(3-nitrobenzylamino)- 7- (trifluoromethyl)quinoline as a novel anticancer agent. J. Med. Chem. 2011, 54, 2127–2142.
  9. Na Ye, QianQian Wu, Liyuan Zhu, Longtai Zheng, Bo Gao, Xuechu Zhen, Ao Zhang: Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands. Bioorg. Med. Chem. 2011, 19, 1999-2008.
  10. Jing Zhang, Kui Wu, Meining Wang, Jianqin Jiang, Ao Zhang: FeCl3.6H2O-promoted skeleton-rearrangement of 1-substituted-3-benzazepines: substrate extension and product utilization. Tetrahedron 2011, 67, 842-848.
  11. Tu, S.; Ding, C.; Hu, W.; Li, F.; Yao, Q.; Zhang A. Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence. Mol Divers. 2011, 15, 91-99.
  12. Fuying Li, Qingzhang Zhu, Yi Zhang, Ying Feng, Ying Leng, Ao Zhang: Design, synthesis and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators. Bioorg. Med. Chem. 2010, 18, 3875-3884.
  13. Chunyong Ding, Shanghui Tu, Qizheng Yao, Fulong Li, Yuanxiang Wang, Wenxiang Hu, Ao Zhang: One-Pot Three-step Synthesis of Naphtho [2,3-a]carbazole-5,13-diones Using Tandem Radical Alkylation-Cyclization -Aromatization Reaction Sequence. Adv Syn Catal 2010, 352, 847-853.
  14. Zhili Liu, Hai Zhang, Na Ye, Jing Zhang, QianQian Wu, Peihua Sun, Linyong Li, Xuechu Zhen, and Ao Zhang: Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist. J. Med. Chem. 2010, 53, 1319-1328.
  15. Yi Zhang, Zhaobin Han, Fuying Li, Kuiling Ding and Ao Zhang: Highly enantioselective hydrogenation of a-aryl-b-substituted acrylic acids catalyzed by Ir-SpinPHOX. Chem. Commun. 2010, 46, 156–158.
  16. Jing Zhang, Ao Zhang: Unprecedented FeCl3·6H2O-Promoted Skeleton-Rearrangement of 1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines: a New Strategy for the Synthesis of C-1 Quaternary Tetrahydroisoquinolines. Chem. Eur. J. 2009, 15, 11119-11122.
  17. Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: [6,7]-Heterocycle-Fused 14-Hydroxymorphinan Derivatives: Design, Synthesis, and Opioid Receptor Activity. ChemMedChem 2009, 4, 2103-2110.
  18. Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Xin Xie, Ao Zhang: Synthesis and SAR study of opioid receptor ligands: momo- and bis-indolomorphinans. Chem Biol Drug Des. 2009, 74, 335-342.
  19. Chunyong Ding, Shanghui Tu, Fuying Li, Yuanxiang Wang, Qizheng Yao, Wenxiang Hu, Hua Xie, Linghua Meng, Ao Zhang: Synthesis Study on Marmycin A: Preparation of the C3’-Desmethyl Analogues. J. Org. Chem. 2009, 74, 6111-6119.
  20. Yuanxiang Wang, Ao Zhang: Expeditious synthesis of 2,3-dihydro-2-alkoxy-3-methylenebenzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides. Tetrahedron 2009, 65, 6986-6990.
  21. Fuying Li, Chenlei Yin, Jie Chen, Jinggen Liu, Ao Zhang: Synthesis and opioid receptor activity of indolopropellanes. Bioorg. Med. Chem. Lett. 2009, 19, 4603-4606.
  22. Jing Zhang, Hai Zhang, Wenxian Cai, Leiping Yu, Xuechu Zhen, Ao Zhang: “Click” D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity. Bioorg. Med. Chem. 2009, 17, 4873-4880.
  23. Xue-Qin Chen, Jing Zhang, John L. Neumeyer, Guo-Zhang Jin, Guo-Yuan Hu, Ao Zhang, Xuechu Zhen: Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects. PLoS One. 2009, 4(6): e5811.
  24. Yu-Jun Wang, Yi-Min Tao, Fu-Ying Li, Yu-Hua Wang, Xue-Jun Xu, Jie Chen, Ying-Lin Cao, Zhi-Qiang Chi, John L. Neumeyer, Ao Zhang, and Jing-Gen Liu: Pharmacological Characterization of ATPM, a Novel Mixed Agonist and µ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J. Pharm. Exp. Ther. 2009, 329, 306-313.
  25. Zhili Li, Jing Zhang, Ao Zhang: Design of multivalent ligand targeting g-protein-coupled receptors.
    Curr Pharm Des. 2009, 15, 682-718.
  26. Jing Zhang, Bing Xiong, Xuechu Zhen, Ao Zhang: Dopamine D1 receptor ligands: Where are we now and where are we going, Med. Res. Rev. 2009, 29, 272-294.