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研究队伍
姓 名:
 黄成钢
性 别:
 男
职 称:
 研究员
学 历:
 博士
电 话:
 
传 真:
 
电子邮件:
 cghuang@mail.shcnc.ac.cn
个人主页:
 
通讯地址:
 上海市祖冲之路555号 201203
简历:

1981 年毕业于桂林医学院药学系,

1989 年硕士毕业于黑龙江中医药大学中药系,

1998 年博士毕业于浙江大学化学系,

2000 年中国科学院上海药物研究所博士后出站留所工作。


研究方向:
中药复方药效物质基础及作用机理研究,现代中药研究开发

专家类别:
研究员

职务:
中科院上海药物所研究员、博士生导师、研究组长、中药现代研究中心副主任

科研成果:

承担科研项目情况:

    多年从事中药及复方的基础研究和新药开发。采用体内多成分分析等先进方法研究中药及复方药效物质基础,特别是口服后吸收进入体内的小分子有效成分群,寻找体内直接作用的药效物质。在此基础上研发单味中药或复方的现代组分中药。主持完成了包括国家基金委重大研究计划项目,国家863项目,国家新药创制重大专项项目,中科院知识创新重要方向项目,上海市科技发展基金项目等多项国家和省部级科研项目。


社会任职:

获奖及荣誉:

代表论著:
  1. Chunhui Ma, Zhixiong Li, Chenggang Huang* et al, Identification of major alkaloids in rat urine by HPLC-DAD-ESI-MS/MS method following oral administration of Cortex Phellodendri decoction, Helvetica Chimica Acta,2009,92:379-398
  2. Haiyan Zhu, Yuanyuan Zhang, Chenggang Huang* et al, In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-β-D-glucopyranoside against Coxsackie Virus B3, Biological & Pharmaceutical Bulletin, 2009, 32(1):68-73
  3. Chunhui Ma,  Yihong Tang, Chenggang Huang* et al, Identification of major alkaloids and steroidal saponins in rat serum by HPLC-DAD-MS/MS method following oral administration of Huangbai-Zhimu herb-pair Extract, Biomedical Chromatography, 2008,22(8):835-850
  4. Chunhui Ma, Longxing Wang, Chenggang Huang* et al, Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction, Biomedical Chromatography, 2008, 22 (10): 1066-1083
  5. Chun-hui Ma,  Ming-song Fan, Cheng-gang Huang* et al, Cytotoxic triterpenoid Saponins from Vaccaria segetalis, Journal of Asian Natural Products Research, 2008, 10(2):177-184
  6. Guan Ye, Rongrong Ma, Chenggang Huang* et al, Determination of calycosin 7-O-β-D-glucoside in rat plasma and urine by HPLC, Biomedical Chromatography, 2007,21:762-767
  7. Hui Wang, Chun-hui Ma,  Chenggang Huang* et al, Identification and determination of four metabolites of mangiferin in rat urine, Journal of Pharmaceutical and Biomedical Analysis, 2007,45:793-798
  8. Yihong Tang, Yuanyuan Zhang, Chenggang Huang* et al, A high-performance liquid chromatographicmethod for saikosaponin a quantification in rat plasma, Biomedical Chromatography, 2007, 21(5):458-62
  9. Guan Ye, Jingjing Fang, Chenggang Huang* et al, Structure elucidation and complete NMR spectral assignments of a novel sesquiterpene glycoside from Ixeris sonchifoli. ,Magnetic Resonance in Chemistry, 2007, 45 (4): 362-363
  10. Kai-cheng Zhu, Chun-hui Ma, Cheng-gang Huang* et al, Two new secoiridoid Glycosides from Tripterospermum Chinense (Migo), Helvetica Chimica Acta, 2007, 90 (2): 291-296
  11. Guan Ye, Hua Peng, Chenggang Huang* et al, A new hopane triterpene from Dipentodon sinicus (Celastraceae), Biochemical Systematics and Ecology, 2007,35:905-908 
  12. Yuanyuan Zhang, Haiyan Zhu, C.G. Huang* et al, Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats, Life Sciences, 2006,78: 1998-2005
  13. Guan Ye, Haiyan Zhu, Chenggang Huang* et al, Determination of geniposide in rat urine after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction by high-performance liquid chromatography, Journal of chromatographic science, 2006, 44(4): 227-300
  14. Yuanyuan Zhang, Haiyan Zhu, Chenggang Huang* et al, Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-γ, Journal of Cardiovascular Pharmacology, 2006, 47(2): 190-195. 
  15. YH Tang, HY Zhu, CG Huang* et al, Determination of human plasma protein binding of baicalin by ulterfiltration and high performance liquid chromatography, Biomedical Chromatography,2006, 20: 1116-1119
  16. Guan Ye, Haiyan Zhu, Chenggang Huang* et al, SPE-HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction, Biomedical Chromatography, 2006, 20: 743-747
  17.  C.H.Ma, W.Ke, C.G. Huang* et al, Large-scale isolation and purification of scoparone from Herba artemisiae scopariae by high-speed counter-current chromatography, Chromatographia, 2006, 64: 83-87
  18.  Hui Wang, Yi-Hong Tang, Cheng-Gang Huang* et al, High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine. Biomedical Chromatography,2006, 20: 1304-1308
  19. Chenggang Huang*,Chunhui Ma, Yihong Tang et al, Clinical Chemistry Research,Chapter 4:Identification and Analysis of Effective Components in Animal Biofluids following Administration of Natural Medicines,Nova Science Publishers Inc.NY, March, 2009