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研究队伍
姓 名:
 章海燕
性 别:
 女
职 称:
 研究员
学 历:
 博士
电 话:
 +86-21-50806710
传 真:
 021-50806710
电子邮件:
 hzhang@simm.ac.cn
个人主页:
通讯地址:
 上海市祖冲之路555号 201203
简历:

教育经历
09/1994 – 07/1998  浙江杭州大学(现浙江大学),生化与微生物专业,学士
09/1998 – 07/2003  中国科学院上海药物研究所,神经药理专业,博士

工作经历
08/2003 – 03/2005  美国Mayo Clinic医学研究所Jacksonville分所,博士后
04/2005 – 02/2007  美国Wake Forest大学,生理与药理系,博士后
02/2007 – 06/2009  中国科学院上海药物研究所,副研究员、研究员
06/2009 – 至今     中国科学院上海药物研究所,研究员、课题组长


研究方向:
主要从事阿尔采末症(Alzheimer’s disease)、血管性痴呆(Vascular dementia)以及缺血性脑卒中的发病机制和治疗策略研究。近年来致力于开展针对胆碱能系统缺损假说的关键问题—— “胆碱能系统昼夜节律需求”、“乙酰胆碱酯酶抑制剂病患亚群反应差异性和外周胆碱能不良反应普遍性”和针对Aβ级联反应假说的核心理论——“Aβ寡聚体毒性”、 “细胞内及细胞器内Aβ毒性”的抗痴呆药物新靶标发现和创新药物研究,以及针对缺血性脑卒中开展新型活性天然产物和SIRT、PSD95-nNOS等靶向型药物研究。

专家类别:
研究员

职务:
中科院上海药物所研究员、博士生导师、课题组长

科研成果:
Trends PharmacolSci, Neurobiol Aging, Free RadicBiol& Med, J Alzheimer DisSCI期刊上发表论文58篇,申请专利14项,授权专利4项。

承担科研项目情况:
1. 上海市科委科技启明星计划, 作用于线粒体功能的分子机制和相关AD治疗策略研究, 2010.4-2012.4
2. 国家自然科学基金青年项目, 胞内Aβ与线粒体在APP转基因动物中的发病机制和治疗策略研究, 2009.1-2011.12
3. 国家自然科学基金面上项目, 胰岛素/IGF-I信号通路在痴呆发病中的平衡调控机制和干预策略研究, 2012.1-2015.12
4. 国家科技重大专项候选药物项目, 新型抗早老性痴呆(AD)候选药物YLV-1的研究, 2009.0-2010.12
5. 国家科技重大专项临床前药物项目(滚动支持), 新型抗早老性痴呆(AD)候选药物YLV-1的临床前研究, 2013.1-2015.12

社会任职:

中国药理学会老年痴呆专业委员会理事
中国药理学报编委
Journal of Alzheimer’s disease编委


获奖及荣誉:

2010年,中国药理学会“施维雅青年药理工作者奖”
2010年,赛诺菲•安万特-中国科学院上海生科院优秀青年人才奖
2013年,上海市青年五四奖章


代表论著:

(2009年以后) 

  1. GuoXJ, Tian XS, Ruan Z, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Dysregulation of Neurotrophic and Inflammatory Systems Accompanied by Decreased CREB Signaling in Ischemic Rat Retina. Exp Eye Res 2014 Jun 19;125C:156-163.
  2. Tian XS, GuoXJ, Ruan Z, Lei Y, Chen YT, Wu L, Gong Q, Wang W, Zhang HY*. Long-term vision and non-vision dominant behavioral deficits in the 2-VO rats are accompanied by time and regional glial activation in the white matter. PLos one 2014 Jun 26;9(6):e101120.
  3.  Huang XT, Qian ZM, He X, Gong Q, Wu KC, Jiang LR, Lu LN, Zhu ZJ, Zhang HY, Yung WH, Ke Y. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiol Aging. 2014; 35: 1045-54.
  4. Tao YM, Fang L, Yang YM, Jiang HL, Yang HY, Zhang HY*, Zhou H*. Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastomaN2a cells. Proteomics. 2013; 13(8): 1314-24.
  5.  Xing WQ, Fu Y, Shi ZX, Lu D, Zhang HY*, Hu YH*. Discovery of novel 2,6-disubstitutedpyridazinone derivatives as acetylcholinesterase inhibitors. Eur J Med Chem. 2013; 63: 95-103.
  6. ZouYQ, Xu L, Chen WY, Zhu YP, Chen TT, Fu Y, Li L, Ma LP, Xiong B, Wang X, Li J, He JH, Zhang HY*, Xu YC*, Li J*, Shen JK*. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors. Eur J Med Chem. 2013; 68: 270-83.
  7. Zhang B, Tang XC, Zhang HY*. Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models. J Neurosci Res. 2013; 91(5): 717-25.
  8. GuoXJ, Chen YT, Liu QF, Wu J, Wang LY, Tang XC, Zhao WM*, Zhang HY*. Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J MolNeurosci. 2013; 50(3): 453-61.
  9. Wang LY, Wu J, Yang Z, Wang XJ, Fu Y, Liu SZ, Wang HM, Zhu WL, Zhang HY*, Zhao WM*. (M)- and (P)-bicelaphanol A, dimerictrinorditerpenes with promising neuroprotective activity from Celastrusorbiculatus. J Nat Prod. 2013; 76: 745-9.
  10.  Wang XJ, Wang LY, Fu Y, Wu J, Tang XC, Zhao WM, Zhang HY*. Promising effects on ameliorating mitochondrial function and enhancing Akt signaling in SH-SY5Y cells by (M)-bicelaphanol A, a novel dimericpodocarpane type trinorditerpene isolated from Celastrusorbiculatus. Phytomedicine. 2013; 20(12):1064-70.
  11.  Liang LF, Wang XJ, Zhang HY, Liu HL, Li J, Lan LF, Zhang W, GuoYW. Bioactive polyhydroxylated steroids from the Hainan soft coral SinulariadepressaTixier-Durivault. Bioorg Med ChemLett. 2013; 23(5): 1334-7.
  12.  Tang Y, Fu Y, Xiong J, Li M, Ma GL, Yang GX, Wei BG, Zhao Y, Zhang HY, Hu JF. Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrumcasuarinoides. J Nat Prod. 2013; 76(8): 1475-84.
  13.   Yang L, Ye CY, Huang XT, Tang XC, Zhang HY*. Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A. J Alzheimers Dis. 2012; 31(1): 131-42.
  14.  Gao X, Zheng CY, Qin GW, Tang XC, Zhang HY*. S-52, a novel nootropic compound, protects against β-amyloid induced neuronal injury by attenuating mitochondrial dysfunction. J Neurosci Res. 2012; 90(10): 1981-8.
  15.  Wang Y, Tang XC, Zhang HY*. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. J Neurosci Res. 2012; 90: 508-17.
  16.  Zhang HY*. New insights into huperzine A for the treatment of Alzheimer's disease. ActaPharmacol Sin. 2012; 33: 1170-5.
  17. Jiang CS, GuoXJ, Gong JX, Zhu TT, Zhang HY*, GuoYW. Synthesis and biological evaluation of 21-arylidenepregnenolone derivatives as neuroprotective agents. Bioorg Med ChemLett. 2012; 22: 2226-9.
  18.  Chen BE, Ye F, Yu L, JiaGF, Huang XT, Zhang XJ, Peng SY, Chen K, Wang MN, Gong SZ, Zhang RH, Yin JY, Li HY, Yang YM, Liu H, Zhang JW, Zhang HY, Zhang A, Jiang HL, Luo C, Yang CG. Development of Cell-Active N(6)-Methyladenosine RNA DemethylaseFTO Inhibitor. J Am Chem Soc. 2012; 134: 17963-71.
  19.  Dong K, Pu JX, Zhang HY, Du X, Li XN, Zou J, Yang JH, Zhao W, Tang XC, Sun HD. Dibenzocyclooctadienelignans from Kadsurapolysperma and their antineurodegenerative activities. J Nat Prod. 2012; 75: 249-56.
  20. Yao LG, Zhang HY, Liang LF, GuoXJ, Mao SC, GuoYW. Yalongenes A and B, Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral SarcophytontrocheliophrumMarenzeller. Helv. Chim. Acta. 2012; 95: 235-9.
  21. Chen HD, Ding YQ, Yang SP, Li XC, Wang XJ, Zhang HY, Ferreira D, Yue JM. Morusalbanol A, a neuro-protective Dielse-Alder adduct with an unprecedented architecture from Morusalba. Tetrahedron. 2012; 68: 6054-8.
  22. Yang JH, Zhang HY, Wen J, Du X, Chen JH, Zhang HB, Xiao WL, Pu JX, Tang XC, Sun HD. Dibenzocyclooctadienelignans with antineurodegenerative potential from Kadsuraananosma. J Nat Prod.2012; 74: 1028-35.
  23.  Wang Y, Yang YS, Tang XC, Zhang HY*. T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities. ActaPharmacol Sin. 2011; 32: 1100-8.
  24.  Wang JR, Liu HL, Kurtán T, Mándi A, Antus S, Li J, Zhang HY, GuoYW. Protolimonoids and norlimonoids from the stem bark of Toonaciliata var. pubescens. Org BiomolChem.2011; 9: 7685-96.
  25. Yang JH, Zhang HY, Du X, Wang W, Xiao WL, Wen J, Pu JX, Tang XC, Sun HD. New dibenzocyclooctadienelignans from the Kadsuraananosma. Tetrahedron. 2011; 67: 4498-504.
  26. Wang J, Zhang HY*, Tang XC. Huperzine A Improves Chronic Inflammation and Cognitive Decline in Rats With Cerebral Hypoperfusion. J Neurosci Res. 2010; 88: 807-15.
  27. Wang Y, Huang LQ, Tang XC, Zhang HY*. Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia. ActaPharmacol Sin. 2010; 31(6): 649-64.
  28. Shi YF, Zhang HY*, Wang W, Fu Y, Xia Y, Tang XC, Bai DL, He XC. Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. ActaPharmacol Sin. 2009; 30(8): 1195-203.
  29.  Gao X, Zheng CY, Yang L, Tang XC, Zhang HY*. HuperzineA Protects Isolated Rat Brain Mitochondria against β-Amyloid Peptide. Free Radical Biol& Med. 2009; 46(11): 1454-62.
  30.  Zhu YP, Xiao K, Ma LP, Xiong B, Fu Y, Yu HP, Wang W, Wang X, Hu DY, Peng HL, Li JY, Gong Q, Chai Q, Tang XC, Zhang HY*, Li J, Shen JK. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and b-secretase. Bioorgan Med Chem. 2009; 17(4): 1600-13.
  31.  Wang J, Zhang HY, Tang XC. Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment. ActaPharmacol Sin. 2009; 30: 879-88.
  32.  Yuan T, Yang SP, Zhang HY, Liao SG, Wang W, Wu Y, Tang XC, Yue JM. Phenolic compounds with cell protective activity from the fruits of Livistonachinensis. J Asian Nat Prod Res. 2009; 11(3):243-9.
  33.  Zhu YP, Xiao K, Yu HP, Ma LP, Xiong B, Zhang HY, Wang X, Li JY, Li J, Shen JK. Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. ActaPharmacol Sin. 2009; 30(2): 259-69.
  34.  Zhu Q, Tang CP, KeCQ, Wang W, Zhang HY, Ye Y. Sesquiterpenoids and Phenylpropanoids from Pericarps of Illiciumoligandrum. J Nat Prod. 2009; 72: 238-42.