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研究队伍
姓 名:
 　许叶春
性 别:
 　女
职 称:
 　研究员
学 历:
 　博士
电 话:
 　
传 真:
 　
电子邮件:
 　ycxu@mail.shcnc.ac.cn
个人主页:
 　http://www.dddc.ac.cn/group/yechun_xu.htm
通讯地址:
 　上海市祖冲之路555号　201203
简历：
许叶春研究员1999年毕业于华东师范大学，获理学学士学位；2001年毕业于华东师范大学，获理学硕士学位；2004年在上海药物研究所获理学博士学位。博士毕业后留所工作一年。2005年至2009年在以色列魏茨曼科学研究所从事博士后研究工作。2009年获“中国科学院引进国外杰出人才计划”（百人计划）资助进入上海药物研究所药物发现与设计中心担任结构生物学组课题组长。

研究方向：
采用结构生物学和计算生物学的多种方法对老年痴呆症密切相关的重要药物靶标以及其他重大疾病相关的膜蛋白的结构功能进行研究，并基于此进行药物设计和改造。

专家类别：
研究员；百人计划

职务：
课题组长

科研成果：

承担科研项目情况：

社会任职：

获奖及荣誉：
  1. CAS-Novo Nordisk Great Wall Professorship (2009)
  2. Dean of Faculty’s Fellowship, Weizmann Institute of Science (2005-2008)
  3. Awards for the national top-100 excellent doctoral dissertations (2006)
  4. SERVIER young investigator awards prize in medicinal chemistry (2005)
  5. “Baojie” scholarship for outstanding PhD students (2003)
  6. “Zhong Shan Wu Mao” scholarship for outstanding graduate students (2000)
  7. The honors of “invention San Qiang Bei in Shanghai” (2000)
  8. The honors of excellent graduate of the East China Normal University (1999)
  9. Third prize of the sixth national session “Tiao Zhan Bei”(1999)

代表论著：
  1. Yechun Xu, Jacques Ph. Colletier, Martin Weik, Hualiang Jiang, John Moult, Israel Silman, Joel L. Sussman. Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray vs MD. Biophys. J. 2008, 95, 2500-2511.
  2. Yechun Xu, Jacques Ph. Colletier, Hualiang Jiang, Israel Silman, Joel L. Sussman, Martin Weik. Induced-fit of preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design. Prot. Sci. 2008, 17, 601-605.
  3. Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang, Francisco J. Barrantes. Mechanics of channel gating of the nicotinic acetylcholine receptor. PLoS Comput. Biol. 2008, 4, e19.
  4. Yechun Xu, Francisco J. Barrantes, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Hualiang Jiang. Blocking of the nicotinic acetylcholine receptor ion channel by chlorpromazine, a noncompetitive inhibitor: a molecular dynamics simulation study. J. Phys. Chem. B 2006, 110, 20640-20648.
  5. Dongxiang Liu, Yechun Xu, Yu Feng, Hong Liu, Xu Shen, Kaixian Chen, Jianpeng Ma, Hualiang Jiang. Inhibitor discovery targeting the intermediate structure of -Amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of -amyloid peptide. Biochemistry 2006, 45, 10963-10972.
  6. Yechun Xu, Xiaomin Luo, Jianhua Shen, Weiliang Zhu, Kaixian Chen, Hualiang Jiang. Molecular dynamics of nicotinic acetylcholine receptor correlating biological functions. Current Protein and Peptide Science 2006, 7, 195-200 (review).
  7. Yechun Xu, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianpeng Ma, Hualiang Jiang. Conformational transition of amyloid -peptide. PNAS 2005, 102, 5403-5407.
  8. Yechun Xu, Francisco J. Barrantes, Xiaomin Luo, Kaixian Chen, Jianhua Shen, Hualiang Jiang. Conformational dynamics of the nicotinic acetylcholine receptor channel: a 35-ns molecular dynamics simulation study. J. Am. Chem. Soc. 2005, 127, 1291-1299.
  9. Yechun Xu, Jianhua Shen, Weiliang Zhu, Xiaomin Luo, Kaixian Chen, Hualiang Jiang. Influence of water molecule on cation- interaction: ab initio second order Møller-Plesset perturbation theory (MP2) calculations. J. Phys. Chem. B. 2005, 109, 5945-5949.
  10. Yechun Xu, Jianhua Shen, Xiaomin Luo, Xu Shen, Kaixian Chen, Hualiang Jiang. Steered molecular dynamics simulations of protein-ligand interactions. Science in China Ser. B Chemistry, 2004, 47:355-366 (review).
  11. Yechun Xu, Jianhua Shen, Xiaomin Luo, Israel Silman, Joel L. Sussman, Kaixian Chen, Hualiang Jiang. How does huperzine A enter and leave the binding gorge of acetylcholinesterase? steered molecular dynamics simulation. J. Am. Chem. Soc. 2003, 125, 11340-11349.