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Han Bin
Professor
Institute of Plant Physiology and Ecology
021-64845260
bhan@ncgr.ac.cn
http://www.ncgr.ac.cn/about_director.asp

Research Focus

Professor HAN is focusing on rice genome sequencing, comparative genome analysis of rice subspecies, and rice functional genomics. Over the past several years, he and his laboratory have successfully finished construction of the physical maps of rice chromosome 4, sequencing and analysis of rice chromosome 4, and expression analysis of rice chromosome 4 using tiling microarray, which were published on Genome Research, Nature and Plant Cell, respectively. With the second generation sequencing technology, he and his laboratory began to develop high-throughput genotyping platform for both high-resolution linkage mapping and genome-wide association studies, and used these approach to dissect complex traits in rice. He and his laboratory also used RNA-Seq technology for global survey and comparison of cultivated rice transcriptomes. These works were published on Genome Research and Nature Genetics.


Biography

Professor HAN Bin obtained his bachelor degree in Biology from Anhui Normal University in 1985, master degree in Biology from Guangxi Agricultural College in 1988, and Ph.D degree in Molecular Genetics from the Sainsbury Laboratory at John Innes Centre in UK in 1992. Between 1992 and 1998, he joined the University of Cambridge, Plant Science Department, as a post doctor. In 1998, he came back to China and serves as the director of the National Center for Gene Research, Chinese Academy of Sciences (CAS). Between 2002 and 2008, he also served as a vice director of Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences (SIBS), CAS. Between 2008 and 2011, he served as a vice director of Beijing Institute of Genomics, CAS. In 2011, he was appointed as a vice president of SIBS, CAS. In 2013, he was elected an academician of CAS.


Selected Publications

1. Feng, Q., Huang, T., Zhao, Q., Zhu, J.J., Lin, Z.X., Han, B (Corresponding Author). Analysis of collinear regions of Oryza AA and CC genomes. J. Genet. Genomics., 36, 667-677 (2009).
2. Gao, Z.Y., Qian, Q., Liu, X.H., Yan, M.X., Feng, Q., Dong, G.J., Liu, J., Han, B (Corresponding Author). Dwarf 88, a novel putative esterase gene affecting architecture of rice plant. Plant Mol Biol., 71, 265-276 (2009).
3. Huang, X.H., Feng, Q., QIan, Q., Zhao, Q., Wang, L., Wang, A.H., Guan, J.P., Fan, D.L., Weng, Q.J., Huang, T., Dong, G.J., Sang, T. & Han, B (Corresponding Author). High-throughput genotyping by whole-genome resequencing. Genome Res., 19, 1068-1076 (2009).
4. Liu, X.L. & Han, B (Corresponding Author). Evolutionary conservation of neighbouring gene pairs in plants. Gene 437, 71-79 (2009). 
5. Hu, W.H., Hu, G.C. & Han, B (Corresponding Author). Genome-wide survey and expression profiling of heat shock proteins and heat shock factors revealed overlapped and stress specific response under abiotic stresses in rice. Plant Sci., 176, 583-590 (2009).
6. Gao, C.X. & Han, B (Corresponding Author). Evolutionary and expression study of the aldehyde dehydrogenase (ALDH) gene superfamily in rice (Oryza sativa). Gene 431, 86-94 (2009). 
7. Lu, G.J., Gao, C.X., Zheng, X.N. & Han, B (Corresponding Author). Identification of OsbZIP72 as a positive regulator of ABA response and drought tolerance in rice. Planta 229, 605-615 (2009).
8. Zheng, X.N., Chen, B., Lu, G.J. & Han, B (Corresponding Author). Overexpression of a NAC trancription factor enhances rice drought and salt tolerance. Biochem Bioph Res Co. 379, 985-989 (2009).
9. Han, B (Corresponding Author). & Zhang, Q.F. Rice genome research: current status and future perspectives. The Plant Genome 1, 71-76 (2008).
10. Huang, X.H., Lu, G.J., Zhao, Q., Liu, X.H. & Han, B (Corresponding Author). Genome-wide analysis of transposon insertion polymorphisms reveals intra-specific variation in cultivated rice. Plant Physiol. 148, 25-40 (2008).
11. Lu, T.T., Yu, S.L., Fan, D.L., Mu, J., Shangguan, Y.Y., Wang, Z.X., Minobe, Y., Lin, Z.X. & Han, B (Corresponding Author). Collection and comparative analysis of 1888 full-length cDNAs from wild rice Oryza rufipogon Griff. W1943. DNA Res. 15, 285-295 (2008).
12. Lu, G.J., Gao, C.X., Zheng, X.N. & Han, B (Corresponding Author). Identification of OsbZIP72 as a positive regulator of ABA response and drought tolerance in rice. Planta DOI 10.1007/s00425-008-0857-3 (2008).
13. Lu, T.T., Huang, X.H., Zhu, C.R., Huang, T., Zhao, Q., Xie, K.B., Xiong, L.Z., Zhang, Q.F. & Han, B (Corresponding Author). RICD: A rice indica cDNA database resource for rice functional genomics. BMC Plant Biol. 8, 118 (2008).
14. Gao, C.X. & Han, B (Corresponding Author). Evolutionary and expression study of the aldehyde dehydrogenase (ALDH) gene superfamily in rice (Oryza sativa). Gene doi:10.1016/j.gene.2008.11.010 (2008).
15. Han, B (Corresponding Author)., Xue, Y.B., Li, J.Y., Deng, X.W. & Zhang, Q.F. Rice functional genomics research in China. Phi. Trans. R. Soc. B 362, 1009-1021 (2007).
16. Liu, X.H., Lu, T.T., Yu, S.L., Li, Y., Huang, Y.C., Huang, T., Zhang, L., Zhu, J.J., Zhao, Q., Fan, D.L., Mu, J., Shangguan, Y.Y., Feng, Q., Guan, J.P., Ying, K., Zhang, Y., Lin, Z.X., Sun, Z.X., Qian, Q., Lu, Y.P. & Han, B (Corresponding Author). A collection of 10,096 indica rice full-length cDNAs reveals highly expressed sequence divergence between Oryza sativa indica and japonica subspecies. Plant Mol Biol. 65, 403-415 (2007).
17. Lu, Y., Gao, C.X. & Han B (Corresponding Author). Sequence analysis of mRNA polyadenlation signals of rice genes. Chinese Sciences Bulletin 51, 1069-1077 (2006).
18. Hu, H., Mu, J., Zhang, H.J., Tao, Y.Z. & Han, B (Corresponding Author). Differentiation of a Miniature Inverted Transposable Element (MITE) System in Asian Rice Cultivars and Its Inference for a Diphyletic Origin of Two Subspecies of Asian Cultivated Rice. J. Integr. Plant Biol. 48, 260-267 (2006).
19. International Rice Genome Sequencing Project. The map-based sequence of the rice genome. Nature 436, 793-800 (2005). (Bin Han is one of the 10 principal investigators of this joint paper).
20. Lu, Y., Wu, Y.R. & Han, B (Corresponding Author). Anaerobic Induction of Isocitrate Lyase and Malate Synthase in Submerged Rice Plants Indicates the Important Metabolic Role of the Glyoxylate Cycle. Acta Biochimica et Biophysica Sinica 37, 406-414 (2005).
21. Jiao, Y.L., Jia, P.X., Wang, X.F., Su, N., Yu, S.L., Zhang, D.F., Ma, L.G., Feng, Q., Jin, Z.Q., Li, L., Xue, Y.B., Cheng, Z.K., Zhao, H.Y., Han, B (co-corresponding Author). & Deng, X.W. A Tiling Microarray Expression Analysis of Rice Chromosome 4 Suggests a Chromosome-Level Regulation of Transcription. Plant Cell 17, 1641-57 (2005). 
22. Zhang, Y.J., Wu, Y.R., Liu, Y.L. & Han, B (Corresponding Author). Computational Identification of 69 Retroposons in Arabidopsis . Plant Physiol. 138, 935-948 (2005).
23. Zhang, Y., Huang, Y.C., Zhang, L., Li, Y., Lu, T.T., Lu, Y.Q., Feng, Q., Zhao, Q., Cheng, Z.K., Xue Y.B., Wing, R.A. & Han, B (Corresponding Author). Structural features of the rice chromosome 4 centromere. Nucleic Acids Res. 32, 2023-2030 (2004).
24. Li, C., Zhang, Yu., Ying, K., Liang, X.L. & Han, B (Corresponding Author). Sequence variations of simple sequence repeats on chromosome-4 in two subspecies of the Asian cultivated rice. Theor Appl Genet. 108, 392–400 (2004).
25. Han, B (Corresponding Author). & Xue, Y.B. Genome-wide intraspecific DNA-sequence variations in rice. Curr. Opin. Plant Biol. 6, 134-138 (2003).
26. Wang, R., Hong, G.F. & Han, B(Corresponding Author). Transcript abundance of rml1, encoding a putative GT1-like factor in rice, is up-regulated by Magnaporthe grisea and down-regulated by light. Gene 324,105–115 (2004).
27. Liu, X.H., Wang, H.W., Li, Y.M., Tang, Y.S., Liu, Y.L., Hua, X., Jia, P.X., Ying, K., Feng, Q., Guan, J.P., Jin, C.Q., Zhang, L., Lou, L.R., Zhou, Z. & Han, B (Corresponding Author). Preparation of single rice chromosome for construction of a DNA library using a laser microbeam trap. J. Biotechnol. 109, 217–226 (2004).
28. Li, T. & Han, B (Corresponding Author). Dampable Waves along Nucleic Acid Sequences Mediating Nucleotides' Interactions. DNA Sequence 15, 135-140(2004).
29. Feng, Q., Zhang, Y.J., Hao, P., Wang, S.Y., Fu, G., Huang, Y.C., Li, Y., Zhu, J.J., Liu, Y.L., Hu, X.,Jia, P.X., Zhang, Y., Zhao, Q., Ying, K., Yu, S.L., Tang, Y.S., Weng, Q.J., Zhang, L., Lu, Y., Mu, J., Lu, Y.Q., Zhang, L., Yu, Z., Fan, D.L., Liu, X.H., Lu, T.T., Li, C., Wu, Y.R., Sun, T.G., Lei, H.Y., Li, T., Hu, H., Guan, J.P., Wu, M., Zhang, R.Q., Zhou, B., Chen, Z.H., Chen, L., Jin, Z.Q., Wang, R., Yin, H.F., Cai, Z., Ren, S.X., Lv, G., Gu, W.Y., Zhu, G.F., Tu, Y.F., Jia, J., Zhang, Y., Chen, J., Kang, H., Chen, X.Y., Shao, C.Y., Sun, Y., Hu, Q.P., Zhang, X.L., Zhang, W., Wang, L.J., Ding, C.W., Sheng, H.H., Gu, G.L., Chen, S.T., Ni, L., Zhu, F.H., Chen, W., Lan, L.F., Lai, Y., Cheng, Z.K., Gu, M.H., Jiang, J.M., Li, J.Y., Hong, G.F., Xue, Y.B. & Han, B (Corresponding Author). Sequence and analysis of rice chromosome 4. Nature 420, 336-40 (2002).
30. Zhao, Q., Zhang, Y., Cheng, Z.K., Chen, M.S., Wang, S.Y., Feng, Q., Huang, Y.C., Li, Y., Tang, Y.S., Zhou, B., Chen, Z.H., Yu, S.L., Zhu, J.J., Hu, X., Mu, J., Ying, K., Hao, P., Zhang, L., Lu, Y.Q., Zhang, L., Liu, Y.L., Yu, Z., Fan, D.L., Weng, Q.J., Chen, L., Lu, T.T., Liu, X.H., Jia, P.X., Sun, T.G., Wu, Y.R., Zhang, Y.J., Lu, Y., Li, C., Wang, R., Lei, H.Y., Li, T., Hu, H., Wu, M., Zhang, R.Q., Guan, J.P., Zhu, J., Fu, G., Gu, M.H., Hong, G.F., Xue, Y.B., Wing, R., J, J.M. & Han, B (Corresponding Author). A fine physical map of the rice chromosome 4. Genome Res. 12, 817-23 (2002).
31. Han, B., Pain, A. & Johnstone, K. Spontaneous duplication of a 661 bp element within a two-component sensor regulator gene causes phenotypic switching in colonies of Pseudomonas tolaasii, cause of brown blotch disease of mushrooms. Mol. Microbiol. 25, 211-218 (1997).

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