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Zhao, Guoping
Academician of Chinese Academy of Sciences, professor
Institute of Plant Physiology and Ecology

Research Focus

Microbial Functional Genomics
Based on Genomics, functional genomics and comparative genomics information, special metabolic processes of microorganisms and the related genetic and biochemical/physiological molecular mechanisms of regulation under different environmental conditions are systematically studied. Metabolic regulation models are being developed based on the knowledge of characterizing signal transduction systems and transcription factors with respect to gene transcription, protein structure and function modification and interaction, as well as the biological small molecules.


ZHAO Guoping, molecular microbiologist, born in Shanghai in 1948, is a professor of Institute of Plant Physiology and Ecology (IPPE), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). Currently, his major administrative positions are executive director of the Chinese National Human Genome Center at Shanghai (CHGCS) and director of the National Engineering Center for BioChip at Shanghai. He is also a professor and director of the Department of Microbiology and Microbial Engineering, School of Life Science, Fudan University. He obtained his B.S. of Microbiology from Fudan University, Shanghai, China in 1982 and Ph.D. of Biochemistry from Purdue University, W. Lafayette, Indiana, USA in 1990. He was the first production manager of Shanghai Promega Biological Products, Ltd. when he returned back to China in 1992. He joined the Shanghai Institute of Plant Physiology, CAS in 1995 as a professor, director of the Microbiology Laboratory and later the deputy director of the institute. He was the director of Shanghai Research Center of Biotechnology, CAS from 1997 to 1999. From 1999 to 2001, he was the vicepresident of SIBS responsible for research and planning. From 2002, he left his post at the SIBS headquarter and gradually moved to the current positions. He was a member of the Advisory Committee for Biotechnology of the State High Technology Development Program (863) from 1996 to 2005 and was elected the academician of the CAS in 2005. Prof. Zhao has been working on the structurefunction relationship and reaction mechanisms of microbial enzymes since his graduate studies. Based on these studies, he is also interested in developing microbial and/or protein engineering technology for industrial application of these enzymes. He developed molecular genetics manipulation systems for studying rifamycin production in a rare actinomycete, Amycolotopsis mediterranei and has been working on cloning and characterizing genes related to the bacterial global regulation, coordinating the primary and secondary metabolisms. Prof. Zhao organized the genomic sequencing and annotation project for Leptospira interrogans. By characterizing some key metabolic pathways and functions of some potential pathogenic genes, new insights are emerging for further indepth study of the disease mechanism. He contributed to the comparative and functional genomic analyses for the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. In particular, employing this model system, the contributions of different genetic variations upon the host specificity phenotype that distinguishing the two different strains of the same species were analyzed in detail. He organized the consortium responsible for the study of SARS molecular epidemiology and SARSCoV evolution. He successfully analyzed the molecular evolution of the virus employing the accurate and comprehensive data of epidemiology. Meanwhile, aided by the mechanism of viral genomic variation and evolution learned via this study, the animal origin of the pathogen was strongly supported, the molecular markers of the epidemiological phases of the pandemic were assigned and the critical amino acid residues related to the crosshost infection of SARSCoV were characterized. This knowledge has laid down a strong foundation for searching the nature reservoir of SARSCoV and for further understanding the mechanism of crosshost infection of emerging zoonotic diseases.

Selected Publications

1. Xu Z, et al, Zhao GP*, Chen H*. (2008) Genome Biology of Actinobacillus pleuropneumoniae JL03, an Isolate of Serotype 3 Prevalent in China. PLoS ONE 3: e1450.


2. Li M, et al, Zhao GP*, Nicholson JK*, Li LJ * and Zhao LP*. (2008) Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl. Acad. Sci. USA. 105: 2117-2122.


3. Zheng H, et al, Zhao G*, Zhang Y*. (2008) Genetic basis of virulence attenuation revealed by comparative genomic analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv. PLoS ONE. 3: e2375.


4. Jun MA, et al, Zhao GP* and Ding JP*. (2008) Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans. Biochem. J. 415: 45-56.


5. Zhang L, Ou XJ, Zhao GP* and Ding XM*. (2008) Highly efficient in vitro site-specific recombination system based on Streptomyces phage BT1 integrase. J. Bacteriol. 190: 6392-6397.
(* corresponding author)


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