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Shi Yufang
Institute of Health Sciences

Research Focus
(1) Molecular mechanisms of activation-induced cell death in T cell subpopulations. T cells respond to antigenic stimulation by rapid proliferation and subsequent quick cell death. Therefore understanding the mechanisms of cell death in different T cell subsets is critical for controlling infections, cancer and autoimmune diseases.
(2) Understanding how immunosuppression is mediated mesenchymal stem cells. Mesenchymal stem cells are critical in tissue repair. It is well known that there is inflammation at the sites of tissue damage. Therefore, it is important to learn how mesenchymal stem cells interact with inflammatory cells and cytokines. We have shown that inflammatory cytokines could make mesenchymal stem cells highly immunosuppressive.
(3) Tumor stroma and tumor immunology. Immune surveillance is critical in keeping us cancer free. When cancer does develop, immunotherapy is the most desirable treatment. However, although various methods have been shown to have effect, none has proven to be the cure. We will focus on tumor stroma (the soil of cancer cells) and to understand how it suppresses immune responses in the tumor microenvironment.


1977-1982        B.S. Degree in Veterinary Medicine, Department of Veterinary Medicine and Animal Sciences, Shandong Agricultural
University, China
1983-1984        Advanced studies, Department of Zoology, Shandong University, China
1984-1985        Advanced study in English, Bell Educational Trust, Ministry of Agriculture and Fishery, China
1985-1988        M.Sc., Department of Zoology, University of Alberta, Edmonton, Canada
1988-1992        Ph.D., Department of Immunology, University of Alberta, Edmonton, Canada


Major Academic Appointments
1982-1985        Teaching staff, Fundamentals in Zoology course, Department of Veterinary Medicine and Animal Science, Shandong
Agricultural University, China
1986-1989        Teaching Assistant, first year Zoology course and the Physiology course, Department of Zoology, University of Alberta, Canada
1992-1995        Postdoctoral Fellow, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
1995-1999        Scientist I (Assistant Professor), Department of Immunology, Holland Laboratory of the American Red Cross, USA
1996-1999        Assistant Professor and Ph.D. Student Supervisor for the Programs of Immunology, Biochemistry, and Oncology, Department of Microbiology and Immunology, George Washington University, USA
1999-2001        Associate Professor (with 20% effort) with Tenure and Ph.D. Student Supervisor for the Programs of Immunology, Biochemistry, and Oncology, Department of Immunology, George Washington University, USA
1999-2001        Scientist II (Tenured Associate Professor), Department of Immunology, Holland Laboratory of the American Red Cross, USA
2001-2003       Associate Professor with Tenure and a University Professor title. Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, USA
2003-present    Full Professor with Tenure and a University Professor title, Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, USA
2001-present    Member of Cancer Institute of New Jersey, USA
2001-present    Member, Team of Infection, Immunology and Hematology, National Space Biomedical Research Institute, NASA, USA
2004-present    Joint Professor, Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, USA
2008-present    Director, Institute of Health Sciences, SIBS, CAS/SJTUSM, China

Selected Publications

1. Swaims AY, Khani F, Zhang Y, Roberts AI, Devadas S, Shi Y*, Rabson AB*. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T-cells. Blood. 2010 [Epub ahead of print] (*equal contribution)

2. Markovina S, Callander NS, O´Connor SL, Xu G, Shi Y, Leith CP, Kim K, Trivedi P, Kim J, Hematti P, Miyamoto S. Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells. Mol Cancer. 2010, 9:176.

3. Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem Cell Res Ther. 2010, 1:5.

4. Arriola A, Kiel ME, Shi Y, McKinnon RD. Adjunctive MSCs enhance myelin formation by xenogenic oligodendrocyte precursors transplanted in the retina. Cell Res. 2010, 20:728-31.

5. Ye W, Gong X, Xie J, Wu J, Zhang X, Ouyang Q, Zhao X, Shi Y, Zhang X. AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. Apoptosis. 2010, 15:474-87.

6. Shi YF, Hu GZ, Su JJ, Li WZ, Chen Q, Shou PS, Xu CL, Chen XD, Huang Y, Zhu ZX, Huang X, Han XY, Xie NX, Ren GW. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010, 20: 519-528.

7. Zhao X, Ren GW, Liang L, Zheng B, Tischfield JA, Shi YF, Shao CS. Brief report: IFN-g induces expansion of Lin-Sca-1+C-Kit+ Cells. Stem Cells. 2010, 28: 122-126.

8. Ren GW, Zhao X, Zhang LY, Zhang JM, L’Huillier A, Ling WF, Roberts AI, Le AD, Shi ST, Shao CS, and Shi YF. Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression. J Immunol. 2010, 184:2321-2328.

9. Qian Y, Shi Y. Natural killer cells go inside: entosis versus cannibalism. Cell Res. 2009; 9:1320-1321.

10. Das J, Ren GW, Zhang LY, Roberts IA, Zhao X, Bothwel ALM, Kaer LV, Shi YF, Das G. Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009 Oct 29;206(11):2407-16.

11. Kong L, Sun L, Zhang H, Liu Q, Liu Y, Qin L, Shi G, Hu JH, Xu A, Sun YP, Li D, Shi YF, Zang JW, Zhu J, Chen Z, Wang ZG, Ge BX. An essential role for RIG-I in toll-like receptor-stimulated phagocytosis. Cell Host Microbe (by Cell Press) 2009, 6:150-161.

12. Vavassori S, Shi Y, Chen CC, Ron Y, Covey LR. In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells. Eur J Immunol 2009, 39:2224-2232.

13. Ren G, Su J, Zhang L, Zhao X, Ling W, L´huillie A, Zhang J, Lu Y, Roberts AI, Ji W, Rabson AB, Shi YF. Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression. Stem Cells. 2009, 27:1954-1962.

14. Xu G, Zhang Y, Zhang L, Roberts, A.I., Shi YF. C/EBPβ Mdiates the Synergistic Upregulation of Gene Expression by IFN-γ and TNF-α in Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells. 2009, 27:942-984.

15. Wang KX, Shi YF, Ron Y, Kazanecki CC, Denhardt DT. Plasma osteopontin modulates chronic restraint stress-induced thymus atrophy by regulating stress hormones: inhibition by an anti-osteopontin monoclonal antibody. Journal of Immunology 2009, 182:2485-2491.

16. Ren GW, Zhang LY, Zhao X, Xu GW, Zhang YY, Roberts AI, Zhao RC, and Shi YF. Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide. Cell Stem Cell (by Cell Press). 2008, 2: 141-150.

17. Wang K, Desai B, Shi YF* and Denhardt DT*. Osteopontin Regulates Hindlimb-unloading-induced Lymphoid Organ Atrophy through Modulating Corticosteroid Production. Proc. Natl. Acad. Sci. USA. 2007, 104: 14777-82 (*equal contribution).

18. Ehirchiou D, Amarnath S, Xiong Y, Xu GU, Chen WJ, Shi YF and Zhang L. CD11b Facilitates the Development of Peripheral Tolerance by Suppressing Th17 Differentiation. J Exp Med. 2007, 204: 1519-24.

19. Devadas S Das, Liu J, Zhang C, Roberts L, Pan AI, Moore Z., P Das G, and Shi Y. Apoptosis Modulates the Th1/Th2 Balance: Distinct Roles for Caspases and Granzyme B. Immunity. 2006, 25: 237-47.

20. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006, 10: 51-64.

21. Das J, Eynott P, Jupp R, Bothwell A, Van Kaer L, Shi YF*§ and Das G*. NKT cells and CD8+ T-cells are dispensable for T-cell dependent allergic airway inflammation. Nature Medicine. 2006, 12: 1345-6. (*equal contribution) (§corresponding author)

22. Das G, Mittal J, Zhang YY, Bothwell A, Van Kare Luc, and Shi YF. Pivotal Roles of Major Histocompatibility Complex Class Ib Restricted CD8+ T Cells in Autoimmune Diseases. J Exp Med. 2006, 203: 2603-11.

23. Pestka S, Krause C, Sarkar D, Walter M, Shi YF, Fisher P. IL-10, Interferons and Related Class 2 Cytokines and Receptors. Ann Rev Immunol. 2004, 22: 929-979.

24. Yin D, Tuthill D, Mufson RA and Shi YF. Chronic restraint stress promotes lymphocyte apoptosis by modulating CD95 expression. J Exp Med. 2000, 191: 1423-1428.

25. Yin D, Mufson RA, Wang R and Shi YF. Fas-mediated cell death promoted by opioids. Nature. 1999, 397: 218.

26. Shi YF, Glynn JM, Guilbert LJ, Cotter TG, Bissonnette RP and Green DR. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. Science. 1992, 257: 212-214. (with cover illustration)

27. Shi YF, Sahai BM and Green DR. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature. 1989, 339: 625-626.


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