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Microbial Resources    
Name:
Changsheng Zhang
Education:
PH.D
Positions:
 
Academic title:
professor
Postal Code:
510301
Subject categories:
Marin Microbiology
Mailing Address:
164 West Xingang Rd., Guangzhou, 510301
E-mail:
czhang@scsio.ac.cn
Resume:

Mar. 2008 – Present                    Professor, South China Sea Institute of Oceanology, China

Jul. 2006 – Mar. 2008           Assistant scientist, School of Pharmacy, University of

Wisconsin-Madison

Jan. 2003 – Jun. 2006           Research associate, School of Pharmacy, University of

Wisconsin-Madison

Sept. 1998 - Dec. 2002         Ph.D., Bergische University Wuppertal, Germany

Aug. 1997 - July 1998          Research assistant, Shanghai Pacific Hi-Biotech Co. Ltd.

Sept. 1994 - July 1997         M.S., Department of Biochemistry, East China Univ. of Sci. & Tech.

Aug. 1990 - July 1994       B.E., Departiment of Biological Science & Technology, Shanghai

Jiao Tong University

Direction:

Discovery, Biosynthesis and Metabolic Engineering of Marine Microbial Natural Proudcts

 
Achievements:
Article:

 1. Changsheng Zhang, Byron R. Griffith, Qiang Fu, Christoph Albermann, Xun Fu, In-Kyoung Lee, Lingjun Li, Jon S. Thorson (2006) Exploiting the Reversibility of Natural Product Glycosyltransferase-catalyzed Reactions. Science, 313(5791): 1291-1294.

2. Gavin J. Williams, Changsheng Zhang, Jon S. Thorson (2007) Expanding the Promiscuity of A Natural Product Glycosyltransferase by Directed Evolution. Nature Chemical Biology, 3 (10): 657-662.

3. Changsheng Zhang, Jiqing Jiang, Rocco Moretti, Jon S. Thorson (2008) The In Vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI. ChemBioChem, 9(15):2506-2514.

4. Changsheng Zhang, Eduardo Bitto, Randal D. Goff, Craig A. Bingman, Byron R. Griffith, Christoph Albermann, George N. Phillips Jr. and Jon S. Thorson (2008) Biochemical and Structural Insights of the Earlyr Glycosylation Steps in Calicheamicin Biosynthesis. Chemistry & Biology, 15(8):842-853.

5. Changsheng Zhang, Christoph Albermann, Xun Fu, Jon S. Thorson (2006) The In Vitro Characterization of the Iterative Avermectin Glycosyltransferase AveBI Reveals Reaction Reversibility and Sugar Nucleotide Flexibility. Journal of the American Chemical Society, 128(51): 16420-16421.

Community service:
Commitment to research the situation:

1.  Biosynthetic Mechanisms of Marine Microbial Secondary Metabolites. Project supported by the State Key Development Program for Basic Research of China (973 Program, Grant No. 2010CB833805, 2010.1-2014.8)

2.  Biosynthesis and Glycodiversification of Amicetin. Project supported by the National Natural Science Foundation of China (Grant No. 30870060, 2009.1-2011.12)

3.  Research and Development of Antibacterial and Antitumor Drugs from Microbial Natural Products. Project supported by the '100 Talents Project' of Chinese Academy of Sciences, China (Grant No. 2060206, 2008.3-2011.2)

4.  Exploring and Exploiting Marine Industrial Microbial Resources of the South China Sea. Project supported by Funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering (Grant No. KSCX2-YW-G-065)

5.  Combinatorial Biosynthesis Of Marine Microbial Natural Products. Project supported by Funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering (Grant No. KZCX2-YW-216, 2007.1-2009.12)