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100 Talents Program of Chinese Academy of Sciences
  Deputy Director of State Key Laboratory of Environmental Chemistry and Eco-toxicology
Highest Education  
  18 Shuangqing Road, Haidian District, Beijing, China
Zip Code  

Education and Appointments:

  Dr. Liu is currently a professor at the Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences. He received Ph.D from the Institute of Developmental Biology and Genetics, the Chinese Academy of Sciences, in 2004. Thereafter, he had his postdoc training in hematology and oncology at MIT and Harvard Medical School from 2004 to 2008. He was a faculty member at Tufts Medical School from 2008 to 2009, embarking on the molecular mechanisms for breast cancer development and metastasis. Dr. Liu joined the Research Center for Eco-Environmental Sciences, the Chinese Academy of Sciences in 2009. 

Research Interest:

the mechanisms responsible for environmental pollutant-mediated oncogenic effects and nanotoxicity 

Public Services:

Dr. Liu is a recipient of NSFC “Outstanding Yong Scientist” award, CAS “One Hundred Talent Program” award, Yong Scientist Award from the 9th International Symposium on Persistent Toxic Substances, and Nature Travel Award from the Gordon conference, 2015.
Selected Publications:

  1. Zhu, J.,Xu, M.,* Gao, M., Zhang, Z.,Xu, Y.,Xia, Y., Liu, S.*(2017) Graphene Oxide-Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents. ACS Nano. 2017, DOI: 10.1021/acsnano.6b07311.  

  2.Ma, J., Li, R., Liu, Y., Qu, G., Liu, J., Guo, W., Song, H., Li, X., Liu, Y., Xia, T., Yan, B., Liu, S.*(2017) Carbon nanotubes disrupt iron homeostasis and induce anemia of inflammation through inflammatory pathway as a secondary effect distant to their portal-of-entry. Small.2017. doi: 10.1002/smll.201603830.  

  3. Ma, J., Li, R., Qu, G., Liu, H., Yan, B., Xia, T., Liu, Y., Liu, S.* (2016) Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines.Nanoscale. 8:18070-18086. 

  4. Chen, Y., Wu, Y., Sun, B., Liu, S.,* Liu, H.* (2017) Two-dimensional nanomaterials for cancer nanotheranostics. Small. 2017. doi: 10.1002/smll.201603446.  

  5. Chen, Y., Xu, M., Zhang, J., Ma, J., Gao, M., Zhang, Z.*, Xu, Y., Liu, S.* (2016) Genome-wide DNA methylation variations upon engineered nanomaterials and their implications in nanosafety assessment. Adv Mater. 29(6):1604580.  

  6. Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.*, Zhang, Z.*, Chen, W.,Liu, S.* (2016) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation. ACS Nano. 10:3267-81. 

  7. Wang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, GI., Liu, S.*, Tian, J., Zhang, T.*, Liu, H.*. (2016) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 28:8379-87. 

  8.Ma, J., Liu, R., Wang, X., Liu, Q., Chen, Y., Valle, RP., Zuo, YY., Xia, T.*, Liu, S.* (2015) Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals. ACS Nano. 9:10498-515. 

  9. ian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M.*, Liu, S.* (2015) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status. Biomaterials. 70:12-22. 

  10. Chen, Y., Zhang, Z., Yang, K., Du, J., Xu, Y.*, Liu, S.* (2015). Myeloid zinc finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress.Oncogene. 34:3839-47. 

  11. Chen, Y., Wang, Z., Xu, M., Wang, X., Liu, R., Liu, Q., Zhang, Z., Xia, T., Zhao, J., Jiang, G., Xu, Y., Liu, S.* (2014). Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells. ACS Nano. 8:5813-25. 

  12. Zhang, C., Zhang, S., Zhang, Z., He, J., Xu, Y.*, Liu, S.* (2014) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc. Oncogene. 33:5582-91. 

  13. Qu, G., Liu, S.*, Zhang, S., Wang, L., Wang,X., Sun, B., Yin, N., Gao, X., Xia,T., Chen, J.J., Jiang,G. (2013). Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages. ACS Nano. 7:5732-45. 

  14. Wang, Z., Liu, S.*, Ma, J., Qu, G., Wang, X., Yu, S., He, J., Liu, J., Xia, T., Jiang, G. (2013). Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells. ACS Nano. 7: 4171-86. 

  15. Qu, G., Zhang, C., Yuan, L., He, J., Wang, Z., Wang, L., Liu, S.*, and Jiang, G. (2012). Quantum Dots Impair Macrophagic Morphology and the Ability of Phagocytosis by Inhibiting the Rho-Associated Kinase Signaling. Nanoscale. 4: 2239-44. 

  16. Suragani, R.N., Zachariah, R.S., Velazquez, J.G., Liu, S., Sun, C.W., Townes, T.M., and Chen, J.J.* (2012) Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119:5276-84. 

  17.Liu, S., Goldstein, R.H., Scepansky, E.M., and Rosenblatt, M.* (2009). Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone. Cancer Res. 69: 8742-51. 

  18. Liu, S., Suragani, R., Wang, F., Han, A., Zhao, W., Andrews, N.C., and Chen, J.J.* (2007). The Function of Heme-Regulated eIF2-alpha Kinase in Murine Iron Homeostasis and Macrophage Maturation. J Clin Invest. 117: 3296-305. 

Supported Projects:
  National 973 program grant, NSFC “Outstanding Yong Scientist” award grant, and the Strategic Priority Research Program grant from the Chinese Academy ofSciences.
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Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, People’s Republic of China