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Sui Nan
Professor
Tel:  86-10-64836689
Fax:  86-10-64872070
Mailing Address:  16 Lincui Road, Chaoyang District, Beijing 100101, China
Email:  suin@psych.ac.cn
Website:  
Resume:
1998 – present   Professor, Institute of Psychology, CAS
1996 – 1998      Associate Professor, Institute of Psychology, CAS
1992 – 1996      Assistant Professor, Institute of Psychology, CAS
Research Interests:

The lab focuses on neural mechanisms of psychological disorders, especially those related to learning and memory, and affects and emotion. We believe that pathological learning and memory (neural plasticity) and/or abnormal emotion circuits underly most of psychological disorders.
For nearly two decades, we have studied opiate addiction in animal models and extented to human studies recently. In the past few years, we also branched out to look at depression from a learning-and-memory/affective angle.
Techniques
We routinely employ behavioral paradigms, pharmacological intervention, biochemical analyses, and molecular and cellular assays. Electrophysiological recording and in vivo imaging system are in process of setting up. In addition, we have access to fMRI and other equiment in the North complex of CAS.
Current Projects
Neural mechanisms of addiction: memory reconsolidation and epigenetics, affective memory, reward system, cognitive control and affective decision-making.
Neural mechanisms of depression: behavioral models of depression in tree shrews (lower primate) and rats, and pharmacological studies of antidepressants.
Effects of prenatal exposure of abusive drugs and mechanisms.

Community service:
Standing director of Beijing Society of Neuroscience, Chairman of Physiological Psychology Branch Of Chinese Psychological Society, and Vice Chairman of Beijing Psychological Society. Chief editor of Advances in Psychological Science. Member of editorial board of Acta Psychologica, Chinese Journal of Drug Dependence, and Frontiers in Behavioral Neuroscience, etc..
Achievements:

Four National patents.
2004 Excellent teacher, University of the Chinese Academy of Sciences, Beijing, China.
2006 Excellent teacher, University of the Chinese Academy of Sciences, Beijing, China.

Selected Publications:

1. Min Feng, Jun Gao, Nan Sui, Ming Li (2015). Effects of central activation of serotonin 5-HT 2A/2C or dopamine D2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test. Psychopharmacology. 
2. Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li (2015). Effects of repeated quetiapine treatment on conditioned avoidance responding in rats. European Journal of Pharmacology. 
3. Wan-Sen Yan, Yong-Hui Li, Lin Xiao, Ning Zhu, Antoine Bechara, Nan Sui (2014). Working memory and affective decision-making in addiction A neurocognitive comparison between heroin addicts, pathological gamblers and healthy controls. Drug and Alcohol Dependence. 
4. Weihai Chen, Qi Zhang, Wenxin Su, Haorong Zhang, Yu Yang, Jing Qiao, Nan Sui, Ming Li (2014). Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats. Pharmacology, Biochemistry and Behavior. 
5. Zhang, J. J., Han, J., & Sui, N * (2014). Okadaic acid blocks the effects of 5-aza-2-deoxycytidine on consolidation, acquisition and retrieval of morphine-induced place preference in rats. Neuropharmacology, 86, 282-293. 
6. Shen F, Duan Y, Jin S, & Sui N *(2014).Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction. Front Behav Neurosci, 8, 333. 
7. Feng M, Gao J, Sui N, Li M.(2014). Effects of central activation of serotonin 5-HT2A/2C or dopamine D 2/3 receptors on the acute and repeated effects of clozapine in the conditioned avoidance response test.Psychopharmacology (Berl). Oct 7. [Epub ahead of print] 
8. Qi, K., Wei, C., Li, Y., & Sui, N. * (2013). Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of morphine conditioned place preference. Front Behav Neurosci, 7, 144. 
9. Gao, J., Li, Y., Zhu, N., Brimijoin, S., & Sui, N. * (2013). Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats. J Psychopharmacol, 27(2), 181-191 
10. Feng, M., Sui, N. *, & Li, M. (2013). Environmental and behavioral controls of the expression of clozapine tolerance: evidence from a novel across-model transfer paradigm. Behav Brain Res, 238, 178-187 
11. Feng, M., Sui, N. *, & Li, M. (2013). Avoidance disruptive effect of clozapine and olanzapine is potentiated by increasing the test trials: further test of the motivational salience hypothesis. Pharmacol Biochem Behav, 103(3), 467-473 
12. Li, C. L., Zhu, N., Meng, X. L., Li, Y. H., & Sui, N. * (2013). Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats. J Psychopharmacol, 27(9), 837-844 
13. Yan, W., Li, Y., & Sui, N. * (2013). The Relationship between Recent Stressful Life Events, Personality Traits, Perceived Family Functioning and Internet Addiction among College Students. Stress Health 
14. Yan, Wan-Sen, Li, Yong-Hui, Xiao, Lin, Zhu, Ning, Bechara, Antoine, & Sui, Nan. *(2013) Working memory and affective decision-making in addiction: A neurocognitive comparison between heroin addicts, pathological gamblers and healthy controls. Drug and Alcohol Dependence 
15. Jiang, X., Zhang, J. J., Wang, M. Y., & Sui, N. *(2013). Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core. Physiol Res 
16. Gao, J., Zhu, N., Feng, M., Meng, X., Sui, N.*, (2012). Intranucleus accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats. PsyCh Journal. 1(1):2–14. 
17. Sun, X.,Meng, X., Li, Y., Wang, L., Feng, J., Sui, N.*, Zhang, Y.*, 2012. GABA attenuates amyloid toxicity by downregulating its endocytosis and improves cognitive impairment. Journal of Alzheimer's Disease. 2012 Jun 6. [Epub ahead of print] 
18. Wu Y, Li Y, Yang X, Sui N.*, (2012). Differential effect of beta-adrenergic receptor antagonism in basolateral amygdala on reconsolidation of aversive and appetitive memories associated with morphine in rats. Addiction Biology. 2012 Mar 28. doi: 10.1111/j.1369-1600.2012.00443.x. [Epub ahead of print] 
19. Wu Y, Li Y, Gao J, Sui N.*, (2012). Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats. European Journal of Pharmacology. 674(2-3): 321-326. 
20. Jiang, J., He, X., Wang, M. Y., & Sui, N.* (2011). Early prenatal morphine exposure impairs performance of learning tasks and attenuates in vitro heterosynaptic long-term potentiation of intermediate medial mesopallium in day-old chicks. Behavioural Brain Research, 219(2):363-6. 
21. He, X. G., Xiao, L., & Sui, N.* (2010). Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks. European Journal of Pharmacology, 627(1-3), 136-141. 
22. He, X. G., Bao, Y. F., Li, Y. H., & Sui, N.* (2010). The effects of morphine at different embryonic ages on memory consolidation and rewarding properties of morphine in day-old chicks. Neuroscience Letters, 482(1), 12-16. 
23. Bai, Y. J., Li, Y. H., Zheng, X. G., Han, J., Yang, X. Y., & Sui, N*. (2009). Orexin A attenuates unconditioned sexual motivation in male rats. Pharmacology Biochemistry and Behavior, 91(4), 581-589. 
24. Li, Y. H., Zheng, X. G., Bai, Y. J., Yang, X. Y., & Sui, N*. (2006). Opposite effects of MK-801 on the expression of food and morphine-induced conditioned place preference in rats. Journal of Psychopharmacology, 20(1), 40-46. 
25. Zheng, X. G., Li, Y. H., Luo, X. J., Xiao, L., Wang, D. M., Liu, J., Sui N.*. (2004). Social crowding sensitizes high-responding rats to psychomotor-stimulant effects of morphine. Pharmacology Biochemistry and Behavior, 79(2), 213-218. 
26. Zheng, X. G., Tan, B. P., Luo, X. J., Xu, W., Yang, X. Y., & Sui, N.*. (2004). Novelty-seeking behavior and stress-induced locomotion in rats of juvenile period differentially related to morphine place conditioning in their adulthood. Behavioural Processes, 65(1), 15-23. 
27. Zheng, X. G., Ke, X., Tan, B. P., Luo, X. J., Xu, W., Yang, X. Y., Sui N.*. (2003). Susceptibility to morphine place conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats. Pharmacology Biochemistry and Behavior, 75(4), 929-935. 
28. Sui, N.*, Hu, J. F., Chen, J., Kuang, P. Z., & Joyce, D. (2001). Reversed effects of RU486 and anisomycin on memory retention of light exposure or corticosterone facilitation in the dark-incubated chicks. Journal of Psychopharmacology, 15(4), 287-291. 
29. Sui, N., & Rose, S. P. R. (1997). Effects of dark rearing and light exposure on memory for a passive avoidance task in day-old chicks. Neurobiology of Learning and Memory, 68(3), 230-238. 
30. Sui, N.*, Sandi, C., & Rose, S. P. R. (1997). Interactions of corticosterone and embryonic light deprivation on memory retention in day-old chicks. Developmental Brain Research, 101(1-2), 269-272 
31. Li, Y. H., Wang, H. Y., Qi, K. K., Chen, X. Y., Li, S., Sui, N., et al. (2011). Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal. Physiology & Behavior, 102(1), 42-50. 
32. Han, J., Li, Y. H., Wang, D. M., Wei, C. G., Yang, X. Y., & Sui, N.* (2010). Effect of 5-aza-2-deoxycytidine microinjecting into hippocampus and prelimbic cortex on acquisition and retrieval of cocaine-induced place preference in C57BL/6 mice. European Journal of Pharmacology, 642(1-3), 93-98. 
33. Li, Y. H., Li, S., Wei, C. G., Wang, H. Y., Sui, N., & Kirouac, G. J. (2010). Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus. Pharmacology Biochemistry and Behavior, 95(1), 121-128. 
34. Li, Y. H., Li, S., Wei, C. G., Wang, H. Y., Sui, N., & Kirouac, G. J. (2010). Orexins in the paraventricularnucleus of the thalamus mediate anxiety-like responses in rats. Psychopharmacology, 212(2), 251-265. 
35. Zhao, L. X., Zhu, Y. S., Wang, D. M., Chen, M., Gao, P., Xiao, W. M., Sui N.,Chen Q. (2010). Morphine induces Beclin 1-and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy, 6(3), 386-394. 
36. Li, Y. H., Li, S., Sui, N., & Kirouac, G. J. (2009). Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats. Pharmacology Biochemistry and Behavior, 93(4), 506-514. 
37. Dong, Z. F., Zhong, W. X., Tian, M., Han, H. L., Mao, R. R., Cao, J., Sui N.,et al. (2008). Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio. Brain Research, 1207, 164-173. 
38. Sun, N., Li, Y., Tian, S., Lei, Y., Zheng, J., Yang, J., Sui N.et al. (2006). Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal. Neuroscience, 138(1), 77-82. 
39. Gao, Y., Atanasova, E., Sui, N., Pancook, J. D., Watkins, J. D., & Brimijoin, S. (2005). Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Molecular Pharmacology, 67(1), 204-211. 
40. Yang, Y., Zheng, X. G., Wang, Y. F., Cao, J., Dong, Z. F., Cai, J. X. Sui N, et al. (2004). Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: Possible mechanisms for corticosterone on opiate addiction. Journal of Neuroscience, 24(10), 2412-2420. 

Grants:

1. The National Basic Research Program (2009CB522002)
Neurobiological Mechanisms of opioid dependence----memory mechanism of opioid dependence(2009-2013)
2. The National Basic Research Program (2003CB515404)
Biological basis and treatment of psychological active substance----Relationship between learning, memory and psychological active substances and its molecular mechanism (2003-2008)
3. Project of Natural Sciences Fund Committee (30770719)
The effect of opiate drugs on brain development and susceptibility of addiction in day-old chicks(2008-2010)
4. Innovation Fund of Chinese Academy of Sciences (KSCX1-YW-R-68)
Brain mechanisms of motivation for opioids seeking during induction and withdrawal (2006-2009)