Publications*, correspondence author
1.Ma, X.W, Wang, H., Jin, S.B., Wu, Y. *, Liang, X.J *Construction of paclitaxel-loaded poly (2-hydroxyethyl methacrylate)-poly (lactide)-1,2-dipalmitoyl-sn- glycero-3-phosphoethanolamine copolymer nanoparticle delivery system and evaluation of its anticancer activity. International Journal of Nanomedicine, in revision
2.Jiang, Q., Ma, H.L., Han, S.Y., Zou, G.Y.*, Gan, Y.L., Wu, Y., and Liang, X.J.*. Multicellular Tumor spheroids (MCTSs) as an in vivo-like model for 3D Imaging of Chemotherapeutics and Nano Materials Penetration. Molecular Imaging, in revision
3.Xue, X., You, S., Zhang, Q., Wu, Y., Zou, G.Z., Wang, P.C., Zhao, Y., Xu, Y., Jia, L., Zhang, X., Liang, X.J*. Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction. Submitted Molecular Pharmaceutics, in revision
4.Deng, H., Xu, Y., Liu, Y.H., Che, Z.J., Guo, H.L., Shan, S., Sun, Y., Liu, X., Huang, K., Ma, X.W., Wu, Y. and Liang, X.J*. Gold nanoparticles with asymmetric polymerase chain reaction for rapid colorimetric detection of DNA sequence. 2011. Analytical Chemistry, in press.
5.Han, S.Y., Wang, H., Liang, X.J., Hu, L.M., Li, M., Wu, Y. Nanoparticle carriers based on copolymers of poly (L-aspartic acid co-L-lactide)-1,2-dipalmitoy l-sn-glycero-3- phosphoethanolamine for drug delivery. J Nanoparticle Research. (2011) 13:4371–4385
6.Kumar, A., Ma, H., Zhang, X., Huang, K., Jin, S.B., Liu, J., Wei, T., Cao, W.P., Liang, X.J*. Ultra Small Gold Nanoparticles Fabricated with Therapeutic and Targeted Peptides for Cancer Treatment. Biomaterials 2012. 33(4): 1180-1189.
7.Meng J., Xing J., Wang Y., Lu J., Zhao, Y., Gao X., Wang, PC, Jia L., Liang, X.J*. Epigenetic modulation of human breast cancer by Metallofullerene nanoparticles: in vitro analysis and in vivo treatment. Nanoscale. 2011 ( 3): 4713-4719
8.Ma, X.W., Wu, Y., Jin, S.B., Tian.Y., Zhang, X.N., Zhao.Y., Yu, L. and Liang, X.J*. Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment. ACS Nano. 2011. 5 (11): 8629–8639.
9.Kumar, A., Boruah, B.M., Liang, X.J*. Gold Nanoparticles: A promising nanomaterial for the diagnosis of Cancer and HIV-AIDS. Journal of Nanomaterials. 2011. 10: 1-17.
10.Ma, X.W., Zhao, Y., Liang, X.J*. Theranostic Nanoparticles engineered for Clinic and Pharmaceutics. Accounts of Chemical Research. 2011. 44(10): 1114–1122
11.Ma, X.W., Zhao, Y., Liang, X.J*. Nanodiamond delivery circumvents tumor resistance to doxorubicin. Acta Pharmacologica Sinica. 2011. 32: 543–544
12.Sun, J.B., Li, Y., Liang, X.J*, Wang, P.C.*. Bacterial Magnetosome: a Novel Biogenetic Magnetic Targeted Drug Carrier with Potential Multi-functions. Journal of Nanomaterials. 2011, 8: 1-13
13.Schneider, J., Grodsinki, P., Liang, X.J. Cancer nanotechnology research in the United States and China: cooperation to promote innovation. WIREs Nanomedicine and Nanobiotechnology, 2011. 3(5): 441-448.
14.Sun C., Yang H., Yuan Y., Tian X., Wang L., Guo Y., Xu L., Lei J., Gao N., Anderson G., Liang, X.J; Chen C., Zhao Y.L., Nie G. J. Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging. JACS, 2011. 133(22): 8617-8624.
15.Huang KY, He ST, Liu YL, He HY, Wang SS, Huo SD, Liang XJ. Controlled synthesis of well-dispersed Au nanoparticles passivated by tiopronin. Science in China G. 2011, 41: 1036-1040.
16.He, H., Ben, H., Liang, X.J*. Application of Nanotechnology for Development of Nanoadjuvants. Journal of Southeast University (Medical Science Edition), 2011, 30(1): 146-151.
17.Guo, ST., Huang, YY., Zhang, WD., Wang, WW., Wei, T., Lin, DS., Xing, JF., Deng, LD., Du, Q., Liang, ZC., Liang, XJ *, Dong, A. Ternary Complexes of Amphiphilic Polycaprolactone-graft-Poly (N,N-dimethylaminoethyl methacrylate), DNA and Polyglutamic-graft-Poly(ethylene glycol) for Gene Delivery. Biomaterials; 2011, 32：4283-4292.
18.Jia, L, Zhao, Y., Liang, X.J. Fast Evolving Nanotechnology and Relevant Programs and Entities in China. Nano Today, 2011. 6(1): 6-11. (IF: 13.237)
19.Wang, T., Zhang, C.*, Liang, X.J, Liang, W., Wu, Y. Hydroxypropyl- β-cyclodextrin Copolymers and Their Nanoparticles as doxorubicin Delivery System. Journal of Pharmaceutical Sciences 2011. 100(3): 1067-1079.
20.Guo, S.T., Huang, Y., Wei, T., Wang, W.D., Wang, W.W., Lin, D., Zhang, X., Kumar, A., Du, Q., Xing, J., Deng, L., Liang, Z., Wang, P., Dong A., and Liang, X.J.* Amphiphilic and Biodegradable Methoxy Polyethylene glycol-block-(polycaprolactone-graft-poly (2-(dimethylamino)ethyl methacrylate)) as an Effective Gene Carrier. Biomaterials, 2011, 32: 879-889.
21.Meng, J., Wang, DL., Wang, PC., Jia, L., Chen, C, Liang, XJ*. Biomedical Activities of Endohedral Metallofullerene Optimized for Pharmaceutics. Journal of Nanoscience and Nanotechnology. 2010, 10: 8610-8616.
22.Xue, X., You, S., Liang, X.J*. Chemotherapeutic resistance of cancer and its related gene therapeutic drugs. Chinese Journal of Medicinal Chemistry. 2010,20 (5): 460-466
23.Guo, S.T., Huang, Y., Jiang, Q., Sun, Y., Deng, L., Liang, Z., Du, Q., Xing, J., Zhao, Y., Wang, P., Dong A., and Liang, X.J.*. Enhanced Gene Delivery and siRNA Silencing by Gold Nanoparticles Coated with Charge-reversal Polyelectrolyte. ACS Nano. 2010. 4(9): 5505-5511.
24.Korotcov A, Shan L, Meng H, Wang TX, Sridhar R, Zhao YL, Liang XJ, Wang PC. A Nanocomplex System as Targeted Contrast Agent Delivery Vehicle for Magnetic Resonance Imaging Dynamic Contrast Enhancement Study. Journal of Nanoscience and Nanotechnology. 2010, 10: 7545-7549.
25.Ma, X., Che, Z., Liu, Y., Guo, T. and Liang, X.J*. Application of Electrophoresis in the Separation of Nanoparticles. Science in China: C. 2010. 40 (10): 1478-1486.
26.Guo, S.T, Qiao, Y., Wang, W., He, H., Deng, L., Xing, J., Xu, J., Liang, X.J., and Dong A. Poly(ε-caprolactone)-graft-poly(2-(N, N-dimethylamino) ethyl methacrylate) Nanoparticles: pH Dependent Thermo-Sensitive Multifunctional Carriers for Gene and Drug Delivery. Journal of Materials Chemistry, 2010, 6935-6941.
27.Wang, Y., LV, J., Ma, X., Wang, D., Ma, H., Chang, Y., Nie, G., Jia, L., Duan, X. and Liang, X.J*. Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model. Current Drug Metabolism, 2010, 11: 507-515.
28.Liang, X.J. *, Meng, H., Wang, Y., He, H., Meng, J., Lu, J., Wang, P. C., Zhao, Y., Gao, X., Sun, B., Chen, C., Xing, G., Shen, D., Gottesman, M. M., Wu, Y., Yin, J.J., Jia, L. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. Proceedings of the National Academy of Sciences of the United States of America. （Proc Natl Acad Sci U S A. ） 2010. 107(16):7449-7454.
29.Ma, H., Wang, P C, Qian, F. and Liang, X.J*. Biological Effects of Nanomaterials and Drugs Measured by the Small-animal SPECT/CT Imaging System IN VIVO. Acta Biophysica Sinica. 2010. 26(8): 691-701.
30.Meng, H., Xing, G., Sun, B., Zhao, F., Lei, H., Li, W., Song, Y., Chen, Z., Yuan, H., Xia, W., Jing, L., Chen, C., Liang, X.J., Zhang, N., Chai, Z, Zhao, Y. Potent angiogenesis inhibition by particulate form of fullerene Derivatives. ACS Nano 2010, 25; 4(5):2773-83.
31.Ma, X.W., Wang, D., Wu, Y., Ho, RJY, Jia, L., Guo, P., Hu, L., Xing, G., Zeng, Y., Liang, X.J*. AIDS Treatment with Novel Anti-HIV Compounds Improved by Nanotechnology. AAPS J. 2010, 12(3):272-278.
32.Xing, J, Deng, L, Guo, S, Dong, A, and Liang, X.J*. Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy In Vivo. Mini-Reviews in Medicinal Chemistry. 2010, 10(2):126-37.
33.Tan, J.J., Cong, X.J., Hu, L.M., Wang, C.X., Jia, L and Liang, X.J*. Therapeutic Strategies Underpinning the Development of Novel Techniques for the Treatment of HIV Infection. Drug Discovery Today. 2010. 15(5): 186-197.
34.Jia, L., Zhao, Y. and Liang, X.J. Current Evaluation of the Millennium Phytomedicine-Ginseng (II): Collected Chemical Entities, Modern Pharmacology, and Clinical Applications Emanated from Traditional Chinese Medicine. Current Medicinal Chemistry, 2009, 16, 2924-2942.
35.Wang, P.C., Blumenthal, R.P., Zhao, Y, Schneider, J.A., Miller, N., Grodzinski, P., Gottesman, M.M., Tinkle, S., Wang, K., Wang, C., Liang, X.J*. Building Scientific Progress without Borders: Nanobiology and Nanomedicine in China and the U.S. Cancer Research. 2009, 69: 5294-5295.
36.Wang, Y.Z., Huang, B., Lv J., and Liang XJ*. Current Status Of Nanotechnology Applied In Biomedicine. Acta Biophysica Sinica 2009, 25(3): 168-174.
37.Wan, L.X., Liang, XJ and Huang YG. Characterization of the ATPase activity of a novel chimeric protein consisting of two nucleotide binding domains of MRP1. Archives of Biochemistry and Biophysics. 2009, 485(2):102-108.
38.Wang YZ， Duan XL，Li YF，Liang XJ*. Multidrug Resistance Mediated by Half ABC Transporter ABCG2. Prog. Biochem. Biophys, 2009, 36(12): 1523-1529.
39.Yin, JJ., Lao, F., Fu, PP., Wamer WG., Zhao, YL, Wang, PC., Qiu, Y., Sun, B, Xing G, Dong, J., Liang, XJ*, Chen, C. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials. 2009, 30(4):611-621 *
40.Wang,P.C, Shan, L., Wang, S.P., Korotcov, A and Liang, XJ. Transferrin Liposome Nanoparticle (TfNIR-LipNBD-Magnevist) – A Tumor Targeting MRI Contrast Agent. Acta Biophysica Sinica. 2008, 24(4):315-322.
41.Liang, X.J. *, Chen, C.Y., Zhao, Y.L., Jia, L., Wang, PC. Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials. Current Drug Metabolism. 2008, Oct; 9(8):697-709.
42.Yin, JJ., Lao, F., Meng, J., Fu, PP., Zhao, YL, Xing G, Gao X, Sun, B, Wang, PC., Chen, C, Liang, XJ*. Inhibition of Tumor Growth by Polyhydroxylated Endohedral Metallofullerenol Nanoparticles Optimized as Reactive Oxygen Species Scavenger. Molecular Pharmacology. 2008, 74: 1132-1140.
43.Liang, X. J.*, Shen, D.W., Yin, J.J., Aszalos, A., and Gottesman, M. M. SIRT1 contributes to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Molecular Cancer Research. 2008, 6(9):1499-1506.
44.Liang, X.J., Choi, Y., Sackett, D.L. and Park, J.K. Inhibition of stathmin enhances CCNU blocking glioma cell migration and invasion. Cancer Research. 2008, 68(13):5267-5272.
45.Gao, X, Xing G, Chu, W, Liang, X.J., Zhao, Y, Jing, L., Yuan, H, Cui, Y, Dong J. The Growth of Complex Nanostructures: Synergism of Dipolar Force and Stacking-Defect in Anisotropic Self-assembly, Advanced Materials. 2008, 20, 1794–1798.
46.Liang, X.J.,Yin, J.J., Taylorc, B, Wincovitch S M., Garfield, S., Shen D.W., Gottesman, M.M. and Aszalose A. Disruption of microfilaments by cytochalasin B decreases accumulation of cisplatin in human epidermal carcinoma and liver carcinoma cell lines. Cancer Chemotherapy and Pharmacology. 2008, 62(6):977-84.
47.Hall MD, Okabe M, Shen, DW, Liang, XJ, and Gottesman, MM. The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy*. Annual Review of Pharmacology and Toxicology. 2008，48: 495-535.
48.Wu WW, Wang G, Liang XJ, Park JK, Shen RF. Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides. Biochem Biophys Res Commun. 2008; 367(1):7-13.
49.Ngo.T.B*, Peng T., *, Liang X.J *., Akeju O., Pastorino S., Zhang W., Fine H.A., Maric D., Wen P.Y., Girolami U.D., Black P.M., Wu W., Shen R.F., Kang D.W., and Park J.K. The 1p encoded protein stathmin modulates the response of malignant gliomas to nitrosoureas. Journal of National Cancer Institute. 2007, 99: 639-652. [*: Equal contribution]
50.Liang, X. J. and Aszalos A. Multidrug transporters as drug targets. Current Drug Targets. 2006, 7 (8): Aug 911-921.
51.Liang, X. J., Mukherjee, S., Shen, D. W., Maxfield, F. R. and Gottesman, M. M. Endocytic Recycling Compartments Altered in Cisplatin-Resistant Cancer Cells . Cancer Research. 2006, 66 (4): Feb 15; 2346-2353.
52.Liang, X. J., Taylor B, Cardelli C, Yin JJ, Annereau JP, Garfield SH, Wincovitch S, Szakacs G, Gottesman, M. M and Aszalos A. Different roles for K+ channels in cisplatin resistant cell lines Argue Against a Critical Role for These Channels in Cisplatin Resistance. Anticancer Research. 2005, 25(6B): 4113-4122.
53.Liang, X. J., Shen, D. W., Chen G. K., Wincovitch S. M., Garfield, S., and Gottesman, M. M. Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum. Journal of Cellular Physiology. 2005, 202 (3): 635-641.
54.Liang, X.J, Shen, D.W, and Gottesman, M.M. Down-regulation and altered localization of g-catenin in cisplatin-resistant adenocarcinoma cells. Molecular Pharmacology. 2004 65 (5): 1217-1224.
55.Liang, X.J, Shen, D.W, and Gottesman, M.M. A pleiotropic defect reducing drug accumulation in cisplatin-resistant cells. Journal of Inorganic Biochemistry. 2004 (98) 1599-1606.
56.Liang, X.J, Yin, J.J., Zhou, J.W., Wang, P. C., Taylor, B., Cardarelli, C., Kozar, M, Forte, R., Aszalos, A. and Gottesman, M. M.: Changes in biophysical parameters of plasma membranes influence cisplatin resistance of sensitive and resistant epidermal carcinoma cells. Experimental Cell Research. 2004, 293: 283-291.
57.Liang, X. J., Shen, D. W., Garfield, S., and Gottesman, M. M. Mislocalization of membrane proteins associated with multidrug resistance in cisplatin-resistanct cancer cell lines. Cancer Research. 2003, 63: 5909-5916.
Book Chapters:
1.Gottesman, M.M., Hall, M.D., Liang, X.J., and Shen, D.W.: Resistance to Cisplatin Results from Multiple Mechanisms in Cancer Cells. In Bonetti, A. Leone, R. Muggia, F. Howell, S.B. (Eds.): Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press, Totowa, New Jersey, 2009, 83-88.
2.Liang, X.J., Chen, C.Y., Zhao, Y.L., Wang, P.C. Circumventing tumor resistance to chemotherapy by nanotechnology. Multi-Drug Resistance in Cancer Series: Methods in Molecular Biology , Zhou, Jun (Ed.), Humana Publisher, New York, 2010; 596: 467-488.
3.Jian Jun Tan, Chang Liu, Li Ming Hu, Cun Xin Wang and Xing-Jie Liang. The State of the Science: a 5-Year Review on the Computer-Aided Design for Global Anti-AIDS Drug Development. HIV-infection - Impact, Awareness and Social Implications of living with HIV/AIDS, Eugenia Barros (Edited), 2011, INTECH open access publisher, ISBN978-953-307-343-9. 2011, 25-46.
4.Liang, X.J. Editing “Nanopharmaceuticals: Potential Application of Nanomaterials. (approx. 800pp) World Scientific Publication Press, New Jersey, 2012. ISBN: 978-981-436-866-7.
