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  您现在的位置: 首页 > 研究队伍
姓    名:
陈春英
性    别:
职    务:
职    称:
研究员
通讯地址:
北京市海淀区中关村北一条11号
邮政编码:
100190
电子邮件:
chenchy(AT)nanoctr.cn

 简历:
 

陈春英 博士,国家纳米科学中心研究员、博士生导师。1996年获得华中理工大学生物医学工程专业医学博士学位。1996年11月至2006年5月,中国科学院高能物理研究所博士后并留所工作;2001年9月-2002年9月,瑞典卡罗林斯卡大学诺贝尔医学生物化学研究所博士后。2006年6月加入国家纳米科学中心。中国毒理学会及国际纯粹与应用化学联合会会员,2007年起担任《生态毒理学报》杂志编委。
目前主要研究方向:(1)高效低毒抗肿瘤纳米药物的研制及其作用机制的研究;(2)典型纳米材料与生物体相互作用的规律及其影响因素;(3)核分析与同步辐射技术及组学技术用于生物体系纳米颗粒暴露和效应标志物的研究。(4)易感人群环境污染物长期暴露的分子毒理学研究。


 研究领域:
  纳米生物医学

 社会任职:
 

 获奖及荣誉:
 

 代表论著:
 

1. Cuicui Ge, Jiangfeng Du, Lina Zhao, Liming Wang, Ying Liu, Denghua Li, Yanlian Yang, Yuliang Zhao, Ruhong Zhou*, Yuliang Zhao*, Zhifang Chai, Chunying*. Binding of Blood Proteins to Carbon Nanotubes Reduces Cytotoxicity. Proceedings of the National Academy of Sciences, 2011, doi/10.1073/pnas.1105270108.pdf

2. Liming Wang, Ying Liu, Wei Li, Xiumei Jiang, Yinglu Ji, Xiaochun Wu*, Ligeng Xu, Yang Qiu, Kai Zhao, Taotao Wei, Yufeng Li, Yuliang Zhao, Chunying Chen*. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. Nano Letters, 2011, 11(2), 772-780.pdf

3. Ying Qu, Wei Li, Yunlong Zhou, Xuefeng Liu, Lili Zhang, Liming Wang, Yu-Feng Li, Atsuo Iida, Zhiyong Tang*, Yuliang Zhao, Zhifang Chai, Chunying Chen*. Full Assessment of Fate and Physiological Behavior of Quantum Dots Utilizing Caenorhabditis elegans as a Model Organism. Nano Letters, 2011, 11(8), 3174-3183.pdf

4. Feng Zhao, Ying Zhao, Ying Liu, Xueling Chang, Chunying Chen*, Yuliang Zhao*. Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials. Small, 2011, 7(10), 1322-1337.pdf

5. Yufeng Li, Chunying Chen. Fate and Toxicity of Metallic and Metal-containing Nanoparticles for Biomedical Applications. Small, 2011, doi/10.1002/smll.
201101059 (Invited review). pdf

6. Yang Li, Ying Liu, Yujian Fu, Taotao Wei, Laurent Le Guyader, Ge Gao, Ru-Shi Liu*, Yanzhong Chang*, Chunying Chen*. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials, 2011, doi:10.1016/j.biomaterials.2011.09.091.pdf 

7. Yuexian Liu, Wei Li, Fang Lao, Ying Liu, Liming Wang, Ru Bai, Yuliang Zhao, Chunying Chen*. Intracellular Dynamics of Cationic and Anionic Polystyrene Nanoparticles without Direct Interaction with Mitotic Spindle and Chromosomes. Biomaterials, 2011, 32(32), 8291-8303.pdf

8. Wei Li, Lina Zhao, Taotao Wei*, Yuliang Zhao*, Chunying Chen*. The Inhibition of Death Receptor Mediated Apoptosis through Lysosome Stabilization Following Internalization of Carboxyfullerene Nanoparticles. Biomaterials, 2011, 32(16), 4030-4041.pdf

9. Weiwei He, Ying Liu, Jinshan Yuan, Jun-Jie Yin*, Xiaochun Wu*, Xiaona Hu, Ke Zhang, Jianbo Liu, Chunying Chen*, Yinglu Ji, Yuting Guo. Au@Pt Nanostructures as Oxidase and Peroxidase Mimetics for Use in Immunoassays. Biomaterials, 2011, 32(4), 1139-1147.pdf

10. Yu-Feng Li, Liang Hu, Bai Li, Xiaohan Huang, Erik H Larsen, Yuxi Gao, Zhifang Chai and Chunying Chen*. Full Quantification of Selenium Species by RP and AF-ICP-qMS with On-line Isotope Dilution in Serum Samples from Mercury-exposed People Supplemented with Selenium-enriched Yeast. J. Anal. Atom. Spectrom., 2011, 26, 224-229.pdf 
 
11. Yang Qiu, Ying Liu, Liming Wang, Ligeng Xu, Ru Bai, Yinglu Ji, Xiaochun Wu*, Yuliang Zhao, Yufeng Li, Chunying Chen*. Surface Chemistry and Aspect Ratio Mediated Cellular Uptake of Au Nanorods. Biomaterials, 2010, 31(30), 7606-7619.pdf 
 
12. Fang Jiao, Ying Liu, Ying Qu, Wei Li, Guoqiang Zhou, Baoyun Sun, Yufeng Li, Chunying Chen*. Studies on Antitumor and Anti-metastatic Activities of Fullerenol in a Mouse Breast Cancer Model. Carbon, 2010, 48, 2231-2243.pdf

13. Ligeng Xu, Ying Liu, Ru Bai, Chunying Chen*. Applications and Toxicological Issues Surrounding Nanotechnology in the Food Industry. Pure Appl. Chem., 2010, 82(2), 349-372 (Invited review).pdf

14. Liming Wang, Yu-Feng Li, Liangjun Zhou, Ying Liu, Li Meng, Ke Zhang, Xiaochun Wu*, Lili Zhang, Bai Li, Chunying Chen*. Characterization of Gold Nanorods in vivo by Integrated Analytical Techniques: Their Uptake, Retention, and Chemical Forms. Anal Bioanal Chem, 2010, 396, 1105-1114.pdf 

15. Xingjie Liang*, Huan Meng, Yingze Wang, Haiyong He, Jie Meng, Juan Lu, Paul C. Wang, Yuliang Zhao*, Xueyun Gao, Baoyun Sun, Chunying Chen, Genmei Xing, Dingwu Shen, Lee Jia, Yan Wu, Jun-jie Yin, Michael M. Gottesmand. Metallofullerene Nanoparticles Circumvent Tumor Resistance to Cisplatin by Reactivating Endocytosis. Proceedings of the National Academy of Sciences, 2010, 107(16), 7449-7454.pdf 
 
16. Yu-Feng Li, Xiaoyan Wang, Liming Wang, Bai Li, Yuxi Gao and Chunying Chen*. Direct Quantitative Speciation of Selenium in Selenium-enriched Yeast and Yeast-based Products by X-ray Absorption Spectroscopy. J. Anal. At. Spectrom., 2010, 25, 426-430.pdf 
17. Fang Lao, Long Chen, Wei Li, Cuicui Ge, Ying Qu, Quanmei Sun, Yuliang Zhao, Dong Han*, Chunying Chen*. Fullerene Nanoparticles Selectively Enter Oxidation-damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis. ACS Nano, 2009, 3(11), 3358-3368.pdf 
 
18. Ying Liu, Fang Jiao, Yang Qiu, Wei Li, Fang Lao, Guoqiang Zhou, Baoyun Sun, Genmei Xing, Jinquan Dong, Yuliang Zhao*, Zhifang Chai, Chunying Chen*. The Effect of Gd@C82(OH)22 Nanoparticles on the Release of Th1/Th2 Cytokines and Induction of TNF-alpha Mediated Cellular Immunity. Biomaterials, 2009, 30, 3934-3945.pdf

19. Junjie Yin, Fang Lao, Peter Fu, Wayne G. Wamer, Yuliang Zhao*, Paul C. Wang, Yang Qiu, Baoyun Sun, Gengmei Xing, Jinquan Dong, Xingjie Liang*, Chunying Chen*. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials, 2009, 30, 611-621.pdf


 承担科研项目情况:
 

科技部973项目、基金委十五重大项目、中科院知识创新工程项目、欧盟FP6合作项目、国际原子能机构合作项目等。