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| Details of the Faculty or Staff |
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Name |
Ju-Min Zhou |
Title |
Professor |
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Highest Education |
China Ph.D. Genetics Zoology |
Address |
Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China |
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Phone |
+86 871 5137652 |
Zip Code |
650223 |
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Fax |
+86 871 5137652 |
E-mail |
zhoujm@mail.kiz.ac.cn, zhouj@wistar.org |
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| Education and Appointments： |
Wistar Committees:
Wistar Training Committee (2002-present),
Seminar Committee (2001-present),
Chair, Seminar Committee (2006-present)
Research Services Committee (2005-2006).
Organizer, Wistar annual Ethics Training (2004-2008).
SURF summer student selection (2002-2008).
Penn Appointment:
Associate faculty, Genetics Department, University of Pennsylvania School of Medicine. (2002-present).
Teaching Responsibilities:
CAMB 605. Cell and Molecular Biology Seminar course for first year graduate students (2002-present).
Thesis committee:
Le Ben Wan, CAMB, UPENN. 2005-2009.
Shu Lin, CAMB, UPENN. 2006-present.
Austin Thiel, CAMB, UPENN. 2008-present.
Penn student prelim exam committee:
Stacie Dilks. CAMB, Upenn. May 2006.
Matthew Buas. CAMB, Upenn. May 2005.
Other Committees:
Faculty tenure promotion committee, Texas A&M University, 2010.
Reviewer for Journals:
Molecular Cell Biology, PNAS, Genes & Development, Molecular Cell, Development, Developmental Biology, Gene
Mechanism of Development, NAR. PLoS Genetics. Cellular and Molecular Life Sciences.
Ad Hoc Reviewer for Grants:NSF (2004-present)
Curriculum vitae:
1982-1986 Fudan University, Shanghai, China. BS. Physiology.
1986-1989 Graduate Research Assistant, Shanghai Institute of Pharmacology, Chinese Academy of Sciences.
1990-1995 Graduate Research Assistant, University of Texas, M.D. Anderson Cancer Center (in the laboratory of Dr. Eric Olson).
1995-2000 Postdoctoral Fellow, University of California at Berkeley, Department of Molecular Genetics (in the laboratory of Dr. Mike Levine).
2002-present Associate faculty, Genetics Department, University of Pennsylvania School of Medicine.
2002-present Faculty member, CAMB graduate group, University of Pennsylvania.
2000-2007 ssistant Professor, The Wistar Institute, Gene Expression & Regulation Program.
2000-2008 2008-present Associate Professor, The Wistar Institute, Gene Expression and Regulation Program
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| Research Interest： |
Gene Expression and Regulation Immunology
Molecular and Cellular Oncogenesis |
| Honors： |
1984-1986 Scholarship Award (top 5%), Department of Biology, Fudan University, Shanghai, China.
1986 graduated summa cum laude. Fudan University, Shanghai, China
Membership in Professional Organizations:
1997-present Member, American Association for the Advancement of Science
1998-present Member, Genetics Society of America
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| Selected Publication： |
1. Schwarz, J.J., Charkraborty, T., Martin, J., Zhou, J. and Olson, E.N. (1992). The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription. Mol. Cell. Biol. 12, 266-275.
2. Li, L., Zhou, J., James, G., Heller-Harrison, R., Czech, M. and Olson, E.N. (1992). FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA binding domains. Cell. 71, 1181-1194.
3. Zhou, J. and Olson, E.N. Dimerization through the Helix-loop-helix motif enhances phosphorylation of the transcription activation domains of myogenin. (1994). Mol. Cell. Biol. 14, 6232-6243.
4. Arnosti, D.N., Gray, S., Barolo, S., Zhou, J. and Levine, M. (1995). The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo, EMBO, J. 15, 3659-3666.
5. Staudinger, J., Zhou, J., Burgess, R., Elledge, S. J. and Olson, E.N. (1995). PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J. Cell Biol. 128, 263-71.
6. Zhou, J., Barolo, S., Szymansky, P. and Levine, M. (1996). The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo. Genes Dev. 10: 3195-3201.
7. Zhou, J., Cai, H.N., Ohtsuki, S, and Levine, M. (1997). The regulation of enhancer-promoter interactions in the Drosophila embryo. Cold Spring Harbor Symp. Quant. Biol. LXII: 307.
8. Zhou, J., Zwicker, J., Szymanski, P., Levine, M., and Tjian, R. (1998). TAFII mutations disrupt Dorsal activation in the Drosophila embryo. PNAS 95, 13483-13488.
9. Zhou, J., and Levine, M. (1999). A novel cis-regulatory element, the PTS, mediates an anti-insulator activity in the Drosophila embryo. Cell 99, 567-575.
10.Zhou, J., Ashe, H., Burks, C., and Levine, M. (1999). Characterization of the transvection mediating region of the Abdominal-B locus in Drosophila. Development 126, 3057-3065.
11.Lin, Q., Wu, D. and Zhou, J. (2003). The promoter targeting sequence facilitates and restricts a distant enhancer to a single promoter in the Drosophila embryo. Development 130, 519-26.
12.Lin, Q., Chen, Q., Lin, L. and Zhou, J. (2004). The Promoter Targeting Sequence mediates epigenetically heritable transcription memory. Genes Dev 18, 2639-51.
13.Zhou, J. and Berger, S. L. (2004). Good fences make good neighbors: barrier elements and genomic regulation. Molecular Cell 16, 500-2.
14.Moon, H., Filippova, G., Loukinov, D., Pugacheva, E., Chen, Q., Smith, S. T., Munhall, A., Grewe, B., Bartkuhn, M., Arnold, R. Ohlsson R, Zhou J, Renkawitz R, Lobanenkov V. (2005). CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep 6, 165-70.
15.Chen, Q., Lin, L., Smith, S., Lin, Q. and Zhou, J. (2005). Multiple Promoter Targeting Sequences exist in Abdominal-B to regulate long-range gene activation. Developmental Biolology 286, 629-36.
16.Lin Q., Chen Q., Lin L., Smith S., and Zhou J. (2007). The Promoter Targeting Sequence mediates enhancer interference in the Drosophila embryos. PNAS 104: 3237-3242.
17.Chen Q., Lin L., Huang J., Smith S., Planck J., Berger S., and Zhou J. (2007) A boundary exists in the LAT HSV-1 genome to separate latent and lytic specific genes. J. Virology 81(10): 5192-201.
18.Smith S., Wickramasinghe P., Olson A., LouKinov D., Lin L., Deng J., Xiong Y., Rux J., Sachidanandam R., Sun H., Lobanenkov V., and Zhou J. (2009). Genome wide ChIP-chip analyses of dCTCF reveal important roles for insulator proteins in Drosophila genome organization. Developmental Biology 2009. 15;328(2):518-28.
19. Lin Q., Lin L., and Zhou J. (2010). Chromatin Insulator and the Promoter Targeting Sequence modulate the timing of long-range enhancer-promoter interactions in the Drosophila embryo. Developmental Biology. 15;339(2):329-337.
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| Supported Projects： |
NIH PO1 (NS 33768, active, 2007-2012)
The mechanism of the latency of the Herpes Simplex Virus. PI Nigel Fraser, UPENN. Project leaders: Jumin Zhou, project 2; Shelley Berger (UPENN), project 3; Tim Block (Drexel Univ), Project 4. $1,300,000.
MARCH OF DIMES BIRTH DEFFECTS FOUNDATION (2009-2012). $260,000.
Identification and characterization of the proteins interacting with the PTS element.
R01 GM 65391-01A1 (NIH 4/1/03-4/30/08). $1,550,000.
Dissecting the Functions of a Novel Cis-Element PTS
MARCH OF DIMES BIRTH DEFFECTS FOUNDATION (6/1/03-5/31/06). $240,000
Facilitating Long Range Enhancer-Promoter Interactions by the PTS Element
EDWARD MALLINCKRODT, JR. FOUNDATION (10/1/04-9/30/05). $100,000
Regulating Enhancer-Promoter Communications in the Hox Gene Cluster by the PTS Element
CONCERN FOUNDATION (7/1/02-6/30/04). $220,000.
Regulating Enhancer-Promoter Interactions by a Novel Cis Element, PTS
W. W. Smith Charitable Trust (09/01/02-08/31/03). $80,000.
Regulation of long Range gene activation by the Promoter Targeting Sequence.
NIH, NCI, Cancer Center New Investigator Award (2001-2005). $250,000
Study specialized regulatory DNA element in development.
Commonwealth Universal Research Enhancement Program, Pennsylvania Department of health (2001-present). $200,000
Leukemia Research Foundation (7/1/01-6/30/02). $75,000
Regulating Enhancer-Promoter Interactions by a Novel Cis Element, PTS |
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