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Details of the Faculty or Staff
Name  
 Bin Liang
Title  
  
Highest Education 
   Ph.D
Address  
 Kunming Institute of Zoology, the Chinese Academy of Sciences. No. 32 Jiao chang Dong lu, Kunming, Yunnan, 650223, P.R.China
Phone  
   +86 871 5181927
Zip Code  
   650223
Fax  
   
E-mail  
   bliang73@yahoo.com　liangb@mail.kiz.ac.cn

Education and Appointments：

Education Background:
2001.09—2004.07   Ph.D    Fudan University
1999.09—2001.07   M.S    Yunnan University
1990.09—1994.07   B.S     Yunnan University

Academic Experiences
2010.07           Kunming Institute of Zoology, Chinese Academy of Science. Professor
2006.10---2010.07   Washington State University, Postdoctoral fellow, Assistant Research Professor
2006.07---2006.10   Albert Einstein College of Medicine of Yeshiva University. Postdoctoral fellow
2004.12---2006.07   University of California, Irvine. Postdoctoral fellow
2004.03---2004.11   Yunnan Academy of Agricultural Sciences.
1994.07---1999.08   Yunnan Academy of Agricultural Sciences.


Research Interest：
Energy homeostasis is complex and tightly regulated. Obesity develops when energy intake excesses energy expenditure. Obesity is often associated with diabetes, cardiovascular diseases, hypertension, and some kinds of cancer. Many factors contribute to obesity, such as environment, lifestyle, intestine microorganisms. Besides, more and more evidences have being showed that genes play significant roles in the development of obesity. More than 40 genes/loci have been reported to involve in obesity so far. Comparison among the genomes of Caenorhabditis elegans, Drosophila melanogaster, and rodents estimated that around 500~800 genes may affect energy homeostasis. But what are they, and how do they function?
My lab is taking the advantages of model organism C. elegans with molecular, genetic and genomic tools to explore the regulation of energy homeostasis and the development of obesity. Ongoing projects we are focusing on are: 1) to explore new fat regulators; the downstream targets of insulin/IGF-1 and TOR (Target of Rapamycin) signaling pathways involved in energy homeostasis; 2) to characterize the functions of different lipids including phospholipids and sphingolipids, which are constitutes of cell membrane and signaling molecules, in organism’s growth, development, immunity, and stresses resistance; 3) to screen and test anti-obesity drugs, and to characterize their mechanisms in C. elegans.
Nonhuman primates are popular animal models of human diseases by biomedical research. Tree shrew (Tupaia belangeri) has been considered a lower primate found in tropical and subtropical regions. It has been getting more and more attention because of its small size, short pregnancy, 4~5 months from birth to maturity, and low cost. Could tree shrew be developed into a new animal model of human diseases? We are carrying out exploration in this area. Currently, we are trying to create diabetic tree shrew in order to better understand the pathogenesis of diabetes as well as the screen and evaluation of anti-diabetes drugs.
Public Services：

Honors：
Selected Publication：

Selected Publications:
1.Gholamali Jafari*, Yusu Xie*, Andrey Kullyev, Bin Liang, and Ji Ying Sze. Regulation of extra-synaptic 5-HT by SERT function in 5-HT-absorbing neurons underscores adaptation behavior in C. elegans. J. Neurosci, 2011, 31(24): 8948-8957. (*contributed equally)
2.Bin Liang*, Xiaoyun Wu. Progress on nonhuman primate models of diabetes mellitus. Zoological Research, 2011, 32(1): 91-96 (*Corresponding author).
3.Bin Liang, Kim Ferguson, Lisa Kadyk, and Jennifer L. Watts. The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. PLoS One, 2010, 5(3): e9869
4.Kyleann K. Brooks, Bin Liang, Jennifer L. Watts. The Influence of Bacterial Diet on Fat Storage in C. elegans. PloS One, 2009, 4(10): e7545.
5.Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze. Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metabolism, 2006 Dec; 4(6):429-440. (Preview see Cell Metabolism, 2006, 4(6): 415-417.) 
Other papers:
1.Liang Bin, Zhang Xinjun,Yang Chen, Guo Bin, Dai Luyuan, Yu Tengqiong, Shen Daleng. Isolation and characterization an avirulent gene from Xanthomonas oryzae pv.oryzae. Journal of Fudan University (Natural Science), 2005, 44(4): 534-539.
2.Liang Bin, Guo Bin, Yang Chen, Zhang Xinjun, Dai Luyuan, Yu Tengqiong, Shen Daleng. Expression of a transcriptional factor from Xanthomonas oryzae pv. oryzae. Journal of Fudan University (Natural Science), 2005, 44(4): 540-543. (This paper was selected by Frontiers of Biology in China, 2006. Vol.1, 127-130.)
3.Bin Liang, Tengqiong Yu, Bin Guo, Chen Yang, Luyuan Dai, Daleng Shen. Cloning and    characterization of a novel avirulence gene (arp3) from Xanthomonas oryzae pv. oryzae. DNA Sequence, 2004, 15(2): 110-117.
4.Liang Bin, Wang Jingwen, Ming Feng, et al. Genetic diversity of Xanthomonas oryzae pv. oryzae from the west of Yunnan japonica rice planted area. Journal of Shanghai Jiaotong University (Agricultural Science), 2003 Vol.21 Suppl. 38-42.
5.Liang Bin, Yun Tengqiong, Xu Furong, et al. Genetic analysis of three Yunnan rice varieties  resistance to rice blast. Scientia Agricultura Sinica, 2002, 35(7): 784-788.
6.Liang Bin, Peng Shaoqiu, Xiao Fanghua, et al. Study on the resistance to rice blast of Yunnan conventional rice germplasms. Chinese J Rice Sci., 2001, 15 (2): 147-150.    
7.Liang Bin, Xiao Fanghua, Huang Feiyuan, et al. Resistance assessment of Yunnan wild rices to rice blast. Chinese J Rice Sci, 1999, 13 (3): 183-185.  


Supported Projects：