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Details of the Faculty or Staff
Name  
 Jing-Fei Huang
Title  
   Vice Director of the Kunming Institute of Zoology
Highest Education 
   Professor
Address  
 Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Phone  
   +86 871 5195183
Zip Code  
   650223
Fax  
   +86 871 5195183
E-mail  
   huangjf@mail.kiz.ac.cn

Education and Appointments：

Jing-Fei Huang, male, born on 12th, March, 1958. Graduated from Department Biology, Yunnan University in 1982. 1982-1996, worked at researching on computation biology in Kunming Institute of Zoology (KIZ), Chinese Academy of Sciences (CAS). 1997, worked at researching on evolution of gene and protein families in the Department of Biochemistry, University of Cambridge, UK, as a research fellow of Royal Society K. C. Wong Fellowships. 1998-date, worked at researching on structural bioinformatics in KIZ, as a Deputy Director, Professor, and Adjunct Professor in University of Science and Technology of China. His main research interest is focused on the structural bioinformatics in structure and function evolution of protein families and superfamilies. He has obtained some grants from National Natural Science Foundation of China, CAS, Ministry of Scientific and Technology of PR China and Natural Science Foundation of Yunnan Province, and published more than 50 papers in Mol. Biol. Evol., FEBS Lett., Structure, Acta Crystall., J. Mol. Struct., J. Theor. Biol., J. Mol. Model., Mammalian Genome and other journals.

Research Interest：

Professor Jing-Fei Huang is the director of structural bioinformatics lab which focused on the relationship between protein sequence, structure and function. We apply Discovery Studio on drug design, virtual screening, and the specific binding type between protein-small molecule, protein-nucleic acid. We explore the evolution history of immune related gene and gene family through comparative genomics. We develop several method to research the relationship between protein structure variance and function diversity. We use system biology method to find candidate drug target in complex disease.
Public Services：

Honors：

1992 The third grade prize of Chinese Academy Sciences Award for Natural Science because of “Studies on Gene function by quantum biology”.
1997  Royal Society KC Wong Fellowships in England
2001  The first grade prize of Yunnan Province Award for Natural Sciences because of “Theoretical biology of triplex DNA structure model and capacity”
Selected Publication：
  1. Sowdhamini, R., Burke, D. F., Huang, J.-F., Mizuguchi, K., Nagaaraajaram, H. A., Srinivasan, N., Steward, R. E. and Blundell, T. L. CAMPASS: A Database of Structural aligned Protein Superfamilies. Structure, 1998. 6: 1087-1094.
  2. Sowdhamini, R., Burke, D. F., Deane, C. M., Huang, J.-F. Mizuguchi, K., Nagaaraajaram, H. A., Srinivasan, N., Steward, R. E. and Blundell, T. L. Protein 3D Structural Databases: Domains, Structurally Aligned Homologues and Superfamilies. Acta Crystall. D, 1998.54：1168-1177.
  3. Huang JF, Liu CQ. Identification of protein superfamily from structure-based sequence motif. Chinese Sci. Bull., 2002, 47: 1377- 1381.
  4. Shi XF, Liu SX, Xiangyu JG, Zhang YP, Huang JF, Liu SQ, Liu CQ. Strcuture analysis of human CCR2b and Primate CCR2b by molecular modeling and molecular dynamics simulation. J. Mol. Model., 2002,8: 217-222.
  5. Huang JF, Different protein tyrosine phosphatase superfamilies resulting from different gene reading frames. Mol. Biol. Evol. 2003, 20: 815-820.
  6. Lin J, Huang JF. Evolution of phenylalanyl-tRNA synthetase by domain losing. Acta Biochim. Biophy. Sin., 2003, 35(12): 1601-1605.
  7. Huang JF, 2005. Challenge of the evolutionary relationship between the  protein sequence, structure and function. 100 Interdisciplinary Science Puzzles of the 21st Century，p. 497－501.
  8. Tang SN, Huang JF. Evolution of different oligomeric glycyl-tRNA synthetases. FEBS Lett., 2005, 579: 1441-1445.
  9. Li Y, Huang JF. Identification and molecular evolution of cow CENP-A gene family. Mamm. Genome, 2008, 19(2):139-143.
  10. Li, G-H, Huang, J-F. CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site annotation. BMC Bioinformatics, 2010, 11: 439-451.
  11. Zhang WQ, Wu WW, Dai L, Zhou PF, Lin WC, Zhang Y, Huang JF, Zhang DL. Deciphering Heterogeneity in Pig Genome Assembly Sscrofa9 by Isochore and Isochore-like Region Analysis. PLoS ONE, 2010, 5 (10): e13303.doi:10.1371/journal.pone.0013303.

Supported Projects：

National Basic Research (973) Program of China, National Innovation Group Program of China, National Natural Science Foundation of China, Knowledge Innovation Program of the Chinese Academy of Sciences