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| Details of the Faculty or Staff |
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Name |
Xin-Tian Hu |
Title |
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Highest Education |
Professor |
Address |
Kunming Institute of Zoology, the Chinese Academy of Sciences
No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China |
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Phone |
+86 871 5197002 |
Zip Code |
650223 |
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Fax |
+86 871 5193083 |
E-mail |
xthu@mail.kiz.ac.cn |
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| Education and Appointments: |
Born in 1966, Hu Xintian is Professor and Tutor Supervisor of Doctors and heads the laboratory of sensorimotor integration. After graduating from the University of Science and Technology of China in 1988, he continued his education by enrolling in a graduate program in the Kunming Institute of Zoology. Two and half years later, under the direction of Professor Jingxia Cai, he received his master’s degree in neuroscience and became a junior faculty member at the institute. In 1994, he went to Princeton University in the United States to pursue a PhD. Supervised by Dr. Charles Gross, who discovered the world famous “face cell” and is a member of the National Academy of Sciences of the United States, Xintian Hu studied the spatial information processing function in the prefrontal cortex of the monkey. Some of his data were published in Science magazine. After receiving his PhD degree in 2000, he took a postdoctoral position at the Baylor College of Medicine to study the neuro-control mechanisms of movement under the direction of David Sparks, a renowned neuroscientist in the study of eye movement control. In 2005, he was awarded the One Hundred Persons Project of the Chinese Academy of Sciences and took his current position at the Kunming Institute of Zoology as a full professor. He currently continues his research on the brain mechanisms of sensory and movement information processing and their integration. |
| Research Interest: |
If the brain is viewed as an information processing system, sensory information from different channels is its input, and the different movements that we make daily are its outputs. As a model for studying the outputs, the eye movement control system of the monkey has several advantages: 1) the load is fixed because the weight of the eye ball is more or less constant through time; 2) the eye movements are relatively simple, since its movements can be approximated as three-dimensional rotations around a fixed point in the space and, therefore, can be measured accurately; and 3) the system consists of structures located in both the brain stem and the cortex, which allows us to study both low and high brain functions. All of these characteristics make the eye movement control system an ideal model to study the mechanisms of brain output. In our lab, we use this system to study the information processing mechanisms and plasticity of the brain. Furthermore, due to the fact that many high functions, such as attention and decision making, are involved in eye movement control, we also study mental disorders such as schizophrenia and depression in the brain by observing the abnormity of eye movements. |
| Selected Publication: |
1.Wu J, Wang W, Li L, Liu L, Wang G, Tan H, Jiang HH, Wang J, Ma Y, Hu X* (2010). A new MRI approach for accurately implanting microelectrodes into deep brain structures of the rhesus monkey (Macaca mulatta). J Neurosci Methods 193: 203-9. 2.Meng Z, Liu C, Hu X*, Ma Y (2010) Irregular morphine administration affects the retention but not acquisition of conditioned place preference in rats. Brain Research 1311: 86-92. 3.Meng Z, Liu C, Hu X*, Ma Y (2009) Somatosensory cortices are required for the acquisition of morphine-induced conditioned place preference. PLoS One 4: e7742. 4.Zhang B, Tan H, Sun NL, Wang JH, Meng ZQ, Li CY, Fraser WA, Hu X*, Carlson S, Ma YY (2008) Maze model to study spatial learning and memory in freely moving monkeys. J Neurosci Methods 170: 111-6 5.Gu C, Li P, Hu B, Ouyang X, Fu J, Gao J, Song Z, Han L, Ma Y, Tian S, Hu X* (2008) Chronic morphine selectively impairs cued fear extinction in rats: implications for anxiety disorders associated with opiate use. Neuropsychopharmacology 33: 666-73. 6.Hu X*, Jiang H, Gu C, Li C, Sparks DL (2007) Reliability of oculomotor command signals carried by individual neurons. Proc Natl Acad Sci U S A 104: 8137-42 7.Wang JH, Zhang B, Meng ZQ, Sun NL, Ma MX, Zhang HX, Tang X, Sanford LD, Wilson FA, Hu XT*, Carlson S, Ma YY (2007) Learning large-scale spatial relationships in a maze and effects of MK-801 on retrieval in the rhesus monkey. Dev Neurobiol 67: 1731-41 8.Liu N, Zhou D, Li B, Ma Y*, Hu X* (2006) Gender related effects of heroin abuse on the simple reaction time task. Addict Behav 31: 187-90 9.Sun N, Li Y, Tian S, Lei Y, Zheng J, Yang J, Sui N, Xu L, Pei G, Wilson FA, Ma Y*, Lei H, Hu X.* (2006) Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal, Neuroscience 138: 77-82. 10.Liu N, Liu Y, Fan Y, Yu H, Wilson FA, Ma Y, Hu X* (2005) EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphinedependence, tolerance and withdrawal in rhesus monkeys, Brain Research 1053: 137-45. |
| Supported Projects: |
Plasticity and signal processing of the brain
This project utilises the saccadic generating circuits as a model. Multi-electrode recording and simultaneous stimulation-recording methods will be used to study the plasticity and signal transformation of the brain.
Using eye movements to study mental disorders Our data indicate that different mental disorders are associated with different kinds of eye movements. We plan to use these eye movement changes to evaluate both the quality of the animal models and the effectiveness of treatments. |
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