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| Details of the Faculty or Staff |
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Name |
Wei-Zhi Ji |
Title |
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Highest Education |
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Address |
Kunming Institute of Zoology, the Chinese Academy of Sciences
No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China |
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Phone |
+86 871 5139413 |
Zip Code |
650223 |
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Fax |
+86 871 5139413 |
E-mail |
wji@mail.kiz.ac.cn |
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| Education and Appointments： |
Prof. Ji was the director of Kunming Institute of Zoology, Chinese Academy of Science in 1996-2005. He is currently the director of Kunming Primate Research Center, CAS. During 1985-1987, Prof. Ji had been working as a scientist in Oregon National Primate Research Center and Smithsonian Institution in US. During 1995-1997, he held visiting professor position in University of Wisconsin. In 1996, Prof. Ji was the director of China-US Joint primate biology laboratory, which was set up by Kunming Institute of Zoology and Wisconsin primate research center.
Prof. Ji has been engaged in primate reproductive biology research for several years and takes the lead in primate stem cell research in China. His lab has established human, monkey, rabbit and mouse embryonic stem cell lines and adult stem cell lines. His study found the mechanism of embryonic stem cells differentiate into neural stem cells in vivo and the integration mechanisms in vitro. Currently, his research focuses on stem cell self-renewal mechanisms and stem cell replacement therapy research, where he has published a lot papers in high level journals of this areas, such as "Stem Cells", "Biology of Reproduction", "Human Reproduction" and other magazines. |
| Research Interest： |
The mechanisms of directed differentiation of embryonic stem cells Animal cloning and the mechanisms of nuclear reprogramming.Cell Reprogramming and Induced Pluripotent Stem CellsThe mechanisms of gametogenesis and fertilization Sperm, oocyte and embryo cryopreservation |
| Honors： |
The First prize for science and technology of Yunnan province in 2001
The Third prize for science and technology of Yunnan province in 2004
The Second prize for science and technology of Yunnan province in 2001 |
| Selected Publication： |
1.Niu Y, Yu Y, Bernat A, Yang S, He X, Guo X, Chen D, Chen Y, Ji S, Si W, Lv Y, Tan T, Wei Q, Wang H, Shi L, Guan J, Zhu X, Afanassieff M, Savatier P, Zhang K, Zhou Q, Ji W* (2010) Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci USA, 107: 17663-7
2.Ji S, Jin L, Guo X, Ji W (2010) Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium. In Vitro Cell Dev Biol Anim 46: 693-701
3.Si W, Lu Y, He X, Ji S, Niu Y, Tan T, Ji W (2010) Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm. Theriogenology 74: 1431-8
4.Jin L, Ji S, Tang X, Guo X, Lu Y, Chen H, Deng H, Zhou Q, Ji W* (2009) Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta). Cell Res, 19: 268-70
5.Yang S, He X, Niu Y, Wang X, Lu B, Hildebrandt TB, Goeritz F, Jewgenow K, Zhou Q, Ji W* (2009) Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys. Theriogenology, 72: 560-5
6.Wang S, Shen Y, Yuan X, Chen K, Guo X, Chen Y, Niu Y, Li J, Xu RH, Yan X, Zhou Q, Ji W* (2008) Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells. J Biol Chem, 283: 35929-40
7.Niu Y, Yang S, Yu Y, Ding C, Yang J, Wang S, Ji S, He X, Xie Y, Tang X, Zhou Q, Ji W* (2008) Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. Cloning Stem Cells, 10: 25-36
8.Wang S, Tang X, Niu Y, Chen H, Li B, Li T, Zhang X, Hu Z, Zhou Q, Ji W* (2007) Generation and characterization of rabbit embryonic stem cells. Stem Cells, 25: 481-49
9.Yang J, Yang S, Beaujean N, Niu Y, He X, Xie Y, Tang X, Wang L, Zhou Q, Ji W* (2007) Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biol Reprod, 76: 36-42
10.Li T, Zheng J, Xie Y, Wang S, Zhang X, Li J, Jin L, Ma Y, Wolf DP, Zhou Q, Ji W* (2005) Transplantable neural progenitor populations derived from rhesus monkey embryonic stem cells. Stem Cells, 23: 1295-303
11.Li T, Wang S, Xie Y, Lu Y, Zhang X, Wang L, Yang S, Wolf D, Zhou Q, Ji W* (2005) Homologous feeder cells support undifferentiated growth and pluripotency in monkey embryonic stem cells. Stem Cells, 23: 1192-9 |
| Supported Projects： |
Key Programs of the Chinese Academy of Sciences
Major State Basic Development Program, China National Science Foundation |
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