Education and Appointments：
Date of Birth:   July, 1972
Education and Research Positions
2004-present Professor Kunming Institute of Zoology, Chinese Academy of Sciences, China
2002-2004 Post-doc University of Liverpool , UK and University of Birmingham at Alabama , USA

1. Antimicrobial Peptides and Innate Immunity

2. Bioactive Peptides and Proteins from Blood-sucking Arthropods’ Salivary Glands

3. Bioactive Peptides and Proteins from Animal Venoms including Amphibians, Snakes,and Arthropods

4. Research and Development of Medicines

Honors：
Supported by China National Funds for Distinguished Young Scientists
Patents (15 items been authorized):
[1] Bombina maxima peptides and their uses as antitumour and anti-HIV agents. ZL 00122417.4
[2] Methods for preparation and pharmaceutical use of Bombina maxima inhibitors. ZL 00122416.6
[3] Methods for preparation and pharmaceutical use of Bombina maxima anti-sperm peptides. ZL 00130617.0
[4] Methods for preparation and uses of Bombina maxima antimicrobial peptides. ZL 00122415.8
[5] Methods for the preparation of and pharmaceutical uses of vasoconstriction factors. ZL 02113517.7
[6] Acidic antimicrobial peptides, DNA sequences, and their pharmaceutical uses. ZL 02113515.0
[7] Methods for preparing the satiety factor and the genes encoding it. ZL 02113516.9
[8] Preparation and nucleotide sequence encoding the Bombina maxima anti-tumour protein. ZL 01107253.9
[9] Preparation and nucleotide sequence encoding the Bombina maxima antimicrobial peptides. ZL 01107255.5
[10] Preparation and nucleotide sequence encoding the Bombina maxima vasodilator factor. ZL01107254.7
[11] Preparation and nucleotide sequence encoding the Bombina maxima neurotrophic factor. 01108520.7
[12] Preparation and nucleotide sequence encoding the Bombina maxima neurotrophic peptide. 01108519.3
[13] Preparation and nucleotide sequence encoding the Bombina maxima neural bradykinin. 01108522.3
[14] Preparation and nucleotide sequence encoding the Bombina maxima bombesin. 01108519.3
[15] Methods of preparation and potential use of Bombina maxima antibacterial peptides. 00122414.X
[16] Methods for the preparation and potential uses of antibacterial peptides from wasp. 200510010664.7
[17] Methods for the preparation and potential uses of neuropeptides from Ixodes sinensis. ZL 200510010665.1
[18] Amolops loloensis antimicrobial peptides, DNA sequences ,and their pharmaceutical uses. ZL 200610010627.0
[19] Amolops loloensis bioactive peptides, DNA sequences, and their pharmaceutical uses. ZL 200610010628.5
[20] Rana grahami insulinotropic factors and their pharmaceutical uses. 200610010769.7
[21] Rana grahami insulinotropic peptides and their pharmaceutical uses. ZL 200610010770.X
[22] Rana graham antibacterial peptides and their uses. 200610010928.3
[23] Encoding genes, derivatives, and pharmaceutical uses of Rana grahami Ala-Arg peptides, ZL 200610010931.5
[24] Rana grahami antitumour peptides and their uses. 200610010929.8
[25] Rana grahami serine protease inhibitors, their coding gene, and usage. 200610010930.0
[26] Amolops loloensis insulinotropic peptides and their pharmaceutical uses. 00610010932.
[27] A novel cyclic peptide BA and usage thereof. 200710065665.0
[28] Rana grahami frog skin peptides, DNA sequences and their pharmaceutical uses. 200710065666.5
[29] Rana grahami growth-inhibitory peptides, encoding genes, derivatives, and their pharmaceutical uses. 200710065667.
[30] Rana grahami skin bioactive peptides, DNA sequences, and their pharmaceutical uses. 200710065668.4
[31] Rana grahami immunoregulatory peptides, encoding genes, derivatives, and their pharmaceutical uses. 200710065669.9
[32] Rana grahami antimicrobial peptides, DNA sequences, and pharmaceutical uses. 200710065670.1
[33] Rana grahami secretory peptides, DNA sequences, and pharmaceutical uses. 200710065672.0
[34] Rana grahami odorranain, DNA sequences, and pharmaceutical uses. 200710065674.X
[35] Immunoregulatory peptides, encoding genes, and usage of Tabanus yao salivary glands. 200810058075.X

2011

1.         Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao. Allergy. 2011; 66: 101-9. (IF 6.62)

2.         Liu X, Liu R, Wei L, Yang H, Zhang K, Liu J, Lai R. Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata. J Pept Sci. 2011; 17: 68-72 (IF 2.3)

2010

1.         Wu J, Wang Y, Liu H, Yang H, Ma D, Li J, Li D, Lai R. Two immunoregulatory peptides with antioxidant activity from tick salivary glands J Biol Chem. 2010; 285: 16606-13. (IF 5.7)

2.         Liu C, Hong J, Yang H, Wu J, Ma D, Li D, Lin D, Lai R. Frog skins keep redox homeostasis by antioxidant peptides with rapid radical-scavenging ability. Free Radic Biol Med. 2010; 48: 1173-81.  (IF 5.4)

3.         Chen M, Che Q, Wang X, Li J, Yang H, Li D, Zhang K, Lai R. Cloning and characterization of the first amphibian bradykinin gene. Biochimie. 2010; 92: 226-31. (IF 3.2)

4.         Lai R. Combined peptidomics and genomics approach to the isolation of amphibian antimicrobial peptides. Methods Mol Biol. 2010; 615: 177-90.

5.         Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R. Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis. Comp Biochem Physiol B. 2010;155: 72-6. (IF 1.5)

6.         Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010; 95: 66-71. (IF 3.5)

7.         Ma D, Gao L, An S, Song Y, Wu J, Xu X, Lai R. A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor. Toxicon. 2010; 55: 45-51. (IF 2.6)

8.         Lu Z, Wang Y, Zhai L, Che Q, Wang H, Du S, Wang D, Feng F, Liu J, Lai R, Yu H. Novel cathelicidin-derived antimicrobial peptides from Equus asinus. FEBS J. 2010; 277: 2329-39. (IF 3.6)

2009

1.         Wang WX, Wang YP, Deng XJ, Dang XL, Tian JH, Yi HY, Li YF, He XF, Cao Y, Xia QY, Lai R, Wen SY, Paskowitz S. Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. J Insect Sci. 2009; 9: 17. (IF 1.0)

2.         Zhang CX, Yang SY, Xu MX, Sun J, Liu H, Liu JR, Liu H, Kan F, Sun J, Lai R, Zhang KY. Serratia nematodiphila sp. nov., associated symbiotically with the entomopathogenic nematode Heterorhabditidoides chongmingensis (Rhabditida: Rhabditidae). Int J Syst Evol Microbiol. 2009; 59: 1603-8. (IF 1.7)

3.         Song Y, Lu Y, Wang L, Yang H, Zhang K, Lai R. Purification, characterization and cloning of two novel tigerinin-like peptides from skin secretions of Fejervarya cancrivora. Peptides. 2009; 30: 1228-32. (IF 2.6)

4.         You D, Hong J, Rong M, Yu H, Liang S, Ma Y, Yang H, Wu J, Lin D, Lai R. The first gene-encoded amphibian neurotoxin. J Biol Chem. 2009; 284: 22079-86. (IF 5.7)

5.      Ma D, Wang Y, Yang H, Wu J, An S, Gao L, Xu X, Lai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. 2009; 8: 2071-9. (IF 9.2)

6.     Liu H, Zhou Y, Liu R, Zhang KY, Lai R. Bacillus solisalsi sp. nov., a halotolerant, alkaliphilic bacterium isolated from soil around a salt lake. Int J Syst Evol Microbiol. 2009; 59: 1460-4. (IF 1.7)

7.     Yang SY, Liu H, Liu R, Zhang KY, Lai R. Saccharibacillus kuerlensis sp. nov., isolated from a desert soil. Int J Syst Evol Microbiol. 2009; 59: 953-7. (IF 15.7)

8.     Zhou Y, Wei W, Wang X, Xu L, Lai R. Azospirillum palatum sp. nov., isolated from forest soil in Zhejiang province, China. J Gen Appl Microbiol. 2009; 55: 1-7. (IF 1.5)

9.     Zhou Y, Wei W, Wang X, Lai R. Proposal of Sinomonas flava gen. nov., sp. nov., and description of Sinomonas atrocyanea comb. nov. to accommodate Arthrobacter atrocyaneus. Int J Syst Evol Microbiol. 2009; 59: 259-63. (IF 1.7)

10.   Yang H, Wang X, Liu X, Wu J, Liu C, Gong W, Zhao Z, Hong J, Lin D, Wang Y, Lai R. Antioxidant peptidomics reveals novel skin antioxidant system. Mol Cell Proteomics. 2009; 8: 571-83. (IF 9.2)

2008

1.     Zhou Y, Wei W, Che Q, Xu Y, Wang X, Huang X, Lai R. Bacillus pallidus sp. nov., isolated from forest soil. Int J Syst Evol Microbiol. 2008; 58: 2850-4. (IF 1.7)

2.     Wang Y, Hong J, Liu X, Yang H, Liu R, Wu J, Wang A, Lin D, Lai R. Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLoS One. 2008; 3: e3217. (IF 4.4)

3.      Wei W, Zhou Y, Wang X, Huang X, Lai R. Sphingobacterium anhuiense sp. nov., isolated from forest soil. Int J Syst Evol Microbiol. 2008; 58: 2098-101. (IF 1.7)

4.     Li J, Wu H, Hong J, Xu X, Yang H, Wu B, Wang Y, Zhu J, Lai R, Jiang X, Lin D, Prescott MC, Rees HH. Odorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoS One. 2008; 3: e2381. (IF 4.4)

5.     Liu R, Liu H, Zhang CX, Yang SY, Liu XH, Zhang KY, Lai R. Sphingobacterium siyangense sp. nov., isolated from farm soil. Int J Syst Evol Microbiol. 2008; 58: 1458-62. (IF 1.7)

6.     Liu R, Liu H, Feng H, Wang X, Zhang CX, Zhang KY, Lai R. Pseudomonas duriflava sp. nov., isolated from a desert soil. Int J Syst Evol Microbiol. 2008; 58: 1404-8. (IF 1.7)

7.      Yan X, Feng H, Yu H, Yang X, Liu J, Lai R. An immunoregulatory peptide from salivary glands of the horsefly, Hybomitra atriperoides. Dev Comp Immunol. 2008; 32: 1242-7. (IF 3.5)

8.      Li J, Wu J, Wang Y, Xu X, Liu T, Lai R, Zhu H. A small trypsin inhibitor from the frog of Odorrana grahami. Biochimie. 2008; 90: 1356-61. (IF 3.2)

9.      Zhang C, Liu J, Xu M, Sun J, Yang S, An X, Gao G, Lin M, Lai R, He Z, Wu Y, Zhang K. Heterorhabditidoides chongmingensis gen. nov., sp. nov. (Rhabditida: Rhabditidae), a novel member of the entomopathogenic nematodes. J Invertebr Pathol. 2008; 98: 153-68. (IF 1.5)

10.   Liu H, Liu R, Yang SY, Gao WK, Zhang CX, Zhang KY, Lai R Flavobacterium anhuiense sp. nov., isolated from field soil. Int J Syst Evol Microbiol. 2008; 58: 756-60. (IF 1.7)

11.   Liu SB, He YY, Zhang Y, Lee WH, Qian JQ, Lai R, Jin Y. A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications. PLoS One. 2008; 3: e1770.

12.   Wang A, Wang J, Hong J, Feng H, Yang H, Yu X, Ma Y, Lai R. A novel family of antimicrobial peptides from the skin of Amolops loloensis. Biochimie. 2008; 90: 863-7. (IF 3.2)

13.   Han J, You D, Xu X, Han W, Lu Y, Lai R, Meng Q. An anticoagulant serine protease from the wasp venom of Vespa magnifica. Toxicon. 2008; 51: 914-22. (IF 2.6)

14.   Che Q, Zhou Y, Yang H, Li J, Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. Peptides. 2008; 29: 529-35. (IF 2.6)

15.   Lu X, Ma Y, Wu J, Lai R. Two serine protease inhibitors from the skin secretions of the toad, Bombina microdeladigitora. Comp Biochem Physiol B 2008; 149: 608-12. (IF 1.5)

16.   Zhou Y, Zhang YQ, Zhi XY, Wang X, Dong J, Chen Y, Lai R, Li WJ. Description of Sinobacter flavus gen. nov., sp. nov., and proposal of Sinobacteraceae fam. nov. Int J Syst Evol Microbiol. 2008; 58: 184-9. (IF 1.7)

17.   Lu J, Yang H, Yu H, Gao W, Lai R, Liu J, Liang X. A novel serine protease inhibitor from Bungarus fasciatus venom. Peptides. 2008; 29: 369-74. (IF 2.6)

18.   Zhang K, Liu H, Sun J, Liu J, Fei K, Zhang C, Xu M, Sun J, Ma X, Lai R, Wu Y, Lin M. Molecular Phylogeny of Geographical Isolates of Bursaphelenchus xylophilus: Implications on the Origin and Spread of this Species in China and Worldwide. J Nematol. 2008; 40: 127-37. (IF 1.5)

2007

1.      Xu X, Yang H, Ma D, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics. 2008; 7: 582-90. (IF 9.6)

2.      Yang H, Xu X, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon. 2008; 51: 289-96. (IF 2.6)

3.      Liu X, You D, Chen L, Wang X, Zhang K, Lai R. A novel bradykinin-like peptide from skin secretions of the frog, Rana nigrovittata. J Pept Sci. 2008; 14: 626-30. (IF 1.7)

4.     Han Y, Yu H, Yang X, Rees HH, Liu J, Lai R. A serine proteinase inhibitor from frog eggs with bacteriostatic activity. Comp Biochem Physiol B 2008; 149: 58-62. (IF 1.5)

5.     Wang X, Song Y, Li J, Liu H, Xu X, Lai R, Zhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuraden. Peptides. 2007; 28: 2069-74. (IF 2.6)

6.      Yu H, Wang X, Liu J, Lai R. A novel algesic peptide derived from skin secretions of the frog Amolops loloensis. J Pept Sci. 2007; 13: 798-802. (IF 1.7)

7.      Lu Y, Ma Y, Wang X, Liang J, Zhang C, Zhang K, Lin G, Lai R. The first antimicrobial peptide from sea amphibian. Mol Immunol. 2008; 45: 678-81. (IF 3.8)

8.     Chen L, Li Y, Li J, Xu X, Lai R, Zou Q. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. Peptides. 2007; 28: 1527-31. (IF 2.6)

9.     Liu X, Wang Y, Cheng L, Song Y, Lai R. Isolation and cDNA cloning of cholecystokinin from the skin of Rana nigrovittata. Peptides. 2007; 28: 1540-4. (IF 2.6)

10.   Zhou Y, Dong J, Wang X, Huang X, Zhang KY, Zhang YQ, Guo YF, Lai R, Li WJ. Chryseobacterium flavum sp. nov., isolated from polluted soil. Int J Syst Evol Microbiol. 2007; 57: 1765-9. (IF 1.7)

11.   Yu H, Yang H, Ma D, Lv Y, Liu T, Zhang K, Lai R, Liu J. Vespid chemotactic peptide precursor from the wasp, Vespa magnifica (Smith). Toxicon. 2007; 50: 377-82. (IF 2.6)

12.   Li J, Zhang C, Xu X, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides. FASEB J. 2007; 21: 2466-73. (IF 7.2)

13.   Xu C, Ma D, Yu H, Li Z, Liang J, Lin G, Zhang Y, Lai R. A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom. Peptides. 2007; 28: 969-73. (IF 2.6)

14.   Li J, Xu X, Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007; 6: 882-94. (IF 9.8)

15.   Zhou Y, Wang X, Liu H, Zhang KY, Zhang YQ, Lai R, Li WJ. Pontibacter akesuensis sp. nov., isolated from a desert soil in China. Int J Syst Evol Microbiol. 2007; 57: 321-5. (IF 1.7)

16.   Li J, Yu H, Xu X, Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahami. Genomics. 2007; 89: 413-8. (IF 3.5)

2006

1.     Xu X, Yang H, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides. 2006; 27: 3053-7. (IF 2.6)

2.      Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor. Biochem Biophys Res Commun. 2006; 350: 983-6. (IF 2.9)

3.     Lu Y, Li J, Yu H, Xu X, Liang J, Tian Y, Ma D, Lin G, Huang G, Lai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis. Peptides. 2006; 27: 3085-91. (IF 2.6)

4.     Zhou Z, Yang H, Xu X, Wang X, Lai R. The first report of kininogen from invertebrates. Biochem Biophys Res Commun. 2006; 347: 1099-102. (IF 2.9)

5.         Liang J, Han Y, Li J, Xu X, Rees HH, Lai R. A novel bradykinin-like peptide from skin secretions of rufous-spotted torrent frog, Amolops loloensis. Peptides. 2006; 27: 2683-7. (IF 2.6)

6.         Yu D, Liang J, Yu H, Wu H, Xu C, Liu J, Lai R. A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum. Biochem Biophys Res Commun. 2006; 343: 585-90. (IF 2.9)

7.         Xu X, Li J, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions of Rana grahami. Toxicon. 2006; 47: 459-64. (IF 2.6)

8.         Zhang YQ, Li WJ, Zhang KY, Tian XP, Jiang Y, Xu LH, Jiang CL, Lai R. Massilia dura sp. nov., Massilia albidiflava sp. nov., Massilia plicata sp. nov. and Massilia lutea sp. nov., isolated from soils in China. Int J Syst Evol Microbiol. 2006; 56: 459-63. (IF 1.7)

9.         Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptides from wasp (Vespa magnifica) venom. Toxicon. 2006; 47: 249-53. (IF 2.6)

10.      Li J, Xu X, Yu H, Yang H, Huang Z, Lai R Direct antimicrobial activities of PR-bombesin. Life Sci. 2006; 78: 1953-6. (IF 1.6)

11.      Yu D, Sheng Z, Xu X, Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis. Peptides. 2006; 27: 31-5. (IF 2.6)

2005

1.     Zhang YX, Lai R, Lee WH, Zhang Y. Frog albumin is expressed in skin and characterized as a novel potent trypsin inhibitor. Protein Sci. 2005; 14: 2469-77. (IF 3.6)

2.      Lee WH, Zhang J, Zhang YX, Jin Y, Lai R, Zhang Y. Maximin 9, a novel free thiol containing antimicrobial peptide with antimycoplasma activity from frog Bombina maxima. FEBS Lett. 2005; 579: 4443-8. (IF 3.5)

3.     Lee WH, Liu SB, Shen JH, Jin Y, Lai R, Zhang Y. Identification and molecular cloning of a novel neuromedin U analog from the skin secretions of toad Bombina maxima. Regul Pept. 2005; 129: 43-7. (IF 2.5)

4.     Lee WH, Li Y, Lai R, Li S, Zhang Y, Wang W. Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification. Eur J Immunol. 2005;35: 1220-9. (IF 5.0)

5.      Liang JG, Zhang J, Lai R, Rees HH. An opioid peptide from synganglia of the tick, Amblyomma testindinarium. Peptides. 2005; 26: 603-6. (IF 2.6)

2004

1.     Lai R, Takeuchi H, Jonczy J, Rees HH, Turner PC. A thrombin inhibitor from the ixodid tick, Amblyomma hebraeum. Gene. 2004; 342: 243-9. (IF 2.6)

2.     Lai R, Takeuchi H, Lomas LO, Jonczy J, Rigden DJ, Rees HH, Turner PC. A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum. FASEB J. 2004; 18: 1447-9. (IF 7.2)

3.     Lai R, Lomas LO, Jonczy J, Turner PC, Rees HH. Two novel non-cationic defensin-like antimicrobial peptides from haemolymph of the female tick, Amblyomma hebraeum. Biochem J. 2004; 379: 681-5. (IF 4.7)

2003

1.     Lai R, Liu H, Lee WH, Zhang Y. Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima. Peptides. 2003; 24: 199-204. (IF 2.6)

2.     Lai R, Liu H, Lee WH, Zhang Y. Two novel Bv8-like peptides from skin secretions of the toad Bombina maxima. Comp Biochem Physiol B 2003; 134: 509-14. (IF 1.5)

2002

1.     Lai R, Yang DM, Lee WH, Zhang Y. Biological activities of skin secretions of the salamander Tylototriton verrucosus. J Nat Toxins. 2002; 11: 245-50. (IF 1.5)

2.     Lai R, Liu H, Hui Lee W, Zhang Y. An anionic antimicrobial peptide from toad Bombina maxima. Biochem Biophys Res Commun. 2002; 295: 796-9. (IF 2.9)

3.     Lai R, Liu H, Lee WH, Zhang Y. A novel proline rich bombesin-related peptide (PR-bombesin) from toad Bombina maxima. Peptides. 2002; 23: 437-42. (IF 2.6)

4.     Lai R, Zheng YT, Shen JH, Liu GJ, Liu H, Lee WH, Tang SZ, Zhang Y. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 2002; 23: 427-35. (IF 2.6)

5.      Lai R, Liu H, Lee WH, Zhang Y. Identification and cloning of a trypsin inhibitor from skin secretions of Chinese red-belly toad Bombina maxima. Comp Biochem Physiol B 2002; 131: 47-53. (IF 1.5)

2001

1.      Lai R, Liu H, Hui Lee W, Zhang Y. A novel bradykinin-related peptide from skin secretions of toad Bombina maxima and its precursor containing six identical copies of the final product. Biochem Biophys Res Commun. 2001, 286: 259-63. (IF 2.9)