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Details of the Faculty or Staff
Name  
 Jian-Fan Wen
Title  
   Vice-director of the State Key Lab
Highest Education 
   Professor
Address  
 Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.Chian
Phone  
   +86 871 5198682
Zip Code  
   650223
Fax  
   +86 871 5198682
E-mail  
   wenjf@mail.kiz.ac.cn

Education and Appointments：
Current Position:
Principal Investigator, Research Professor, Vice-director of the State Key Lab
Education :
1996– Ph.D. in Zoology, Kunming Institute of Zoology, CAS.
1989 - Master of Science, Kunming Institute of Zoology, CAS.
1986 - Bachelor of Science, Hunan Normal University.

His group is mainly interested in the origin and evolution of the eukaryotic cell. Taking the protists, especially including those occupying very key positions in the eukaryotic cell evolution, as materials, and combining with the data of prokaryotes and multicelluar organisms, they study the origin and evolution of the structures and functions, especially of genes, gene families and the genome, of the eukaryotic cell. They also study the control of some harmful organisms (e.g. parasitic protozoa) at the angle of evolutionary genomics

Research Interest：
Dr, Wen’s Research interest is about the origin and evolution of the eukaryotic cell. At cellular and molecular levels, to investigate the biodiversity of cellular structures, functions, genes and genomes in eukaryotes of different evolutionary positions, and study the evolution of these aspects of eukaryotic cells.
Public Services：

Honors：
1) 2006, Yunan Province Award for Natural Sciences: The origin and evolution of nuclear matrix and lamina. (second class)
2) 2000, Beijing Science and Technology Advancement Award: The isolation, gene type and nucleus of Giardia from China. (second class)
3) 1999, Yunan Province Award for Natural Sciences: The phylogeny of dinoflagellates. (second class)
Selected Publication：
1、 Sun J., Jiang H.- F., Flores R., Wen J. -F.* 2010. Gene duplication in the genome of parasitic Giardia lamblia. BMC Evol Biol. 10:49.
2、 Zhang Y.- J., Tian H.- F., Wen J.- F.* 2009. The evolution of YidC/Oxa/Alb3 family in the three domains of life: a phylogenomic analysis. BMC Evol Biol. 9:137.
3、 Chen B., Wen J.- F.* 2011. The adaptive evolution divergence of triosephosphate isomerases between parasitic and free-living flatworms and the discovery of a potential universal target against flatworm parasites. Parasitol Res. DOI: 10.1007/s00436-010-2249-4.
4、 Zhang Y.- Q., Chen D.- L., Tian H.- F., Zhang B.- H., Wen J.- F.* 2009. Genome-wide computational identification of microRNAs and their targets in the deep-branching eukaryote Giardia lamblia. Comput Biol Chem. 33(5):391-6.
5、 Sun G.- L., Shen W. and Wen J.- F.* 2008. Triosephosphate isomerase (TIM) genes in two trophic modes of euglenoids (Euglenophyceae) and their phylogenetic analysis. J Eukaryot Microbiol. 55(3):170-177.
6、 Dong J.- H., Wen J.- F.*, Tian H.- F. 2007. Homologs of eukaryotic Ras superfamily   proteins in prokaryotes and their novel phylogenetic correlation with their eukaryotic analogs. Gene 396:116-124.
7、 Xin D.-D., Wen J.-F.*, He D. & Lu S.-Q. 2005. Identification of a Giardia krr1 homolog gene and the secondarily anucleolate condition of Giaridia lamblia. Mol. Biol. Evol. 22(3): 391-394
8、 He D., Wen J. –F.*, Chen W.-Q., Lu S.-Q. & Xin D.-D. 2005. Identification, Characteristic and Phylogenetic Analyses of Type II DNA topoisomerase Gene in  Giardia lamblia. Cell Res. 15(6): 474-482.
9、 Shen W., Wen J. –F.*, Sun G.-L. and Lu Y. 2005. Identification of TIM genes from Microcystis (Cyanobacteria: Chroococcales) and theoretic analyses of the potential of cyanobacterial TIM as a target for designing specific inhibitors.” Phycologia 44(4): 447-452.
10、Wen J.-F.*, 2000. The Nuclear Matrix of Euglena gracilis (Euglenophyta): A stage of nuclear matrix evolution? Biol. Cell 28(5): 125-131.

Supported Projects：
Research in the Wen Lab focuses broadly on the evolution of eukaryotic cells. At cellular and molecular levels, we investigate the biodiversity of cellular structures, functions, genes and genomes in eukaryotes of different evolutionary positions, and study the evolution of these aspects of eukaryotic cells. Unicellular eukaryotes, protists, such as Giardia, Euglena, Chlamydomonas, and Choanoflagellates, which occupy key positions in the evolution of eukaryotic cells, are our preference materials. Combining with data of the ‘upstream’ organisms, prokaryotes, and the ‘downstream’ organisms, multicelluar eukaryotes, currently, we are focusing on the following aspect of the evolution of eukaryotic cells:
1) The biodiversity and evolution of some important eukaryotic cellular structures, including nuclear matrix and lamina, chromatin, and nucleolus;
2) The biodiversity and evolution of some important eukaryotic cellular functions and mechanisms, including nuclear division, cellular protein targeting, glycolysis, Calvin cycle, and biosynthesis of phospholipid;
3) The biodiversity and evolution of genes, gene families, functional pathway gene groups, and sub-genomes (e.g. nucleolar genome) of the above structures and functions.
4)  The adaptive evolution of some pests or pathogens (e.g. Giardia, Trichomonas, schistosome, and bloom cynobacteria) at genome level, and specific effective molecular targets for the control and treatment of this organisms.
The Wen Lab is a part of the State Key Laboratory of Genetic Resources and Evolution.