Yong-Tang Zheng----Kunming Institute of Zoology Chinese Academy of Sciences

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Details of the Faculty or Staff
Name	Yong-Tang Zheng	Title
Highest Education	Professor	Address	Kunming Institute of Zoology, the Chinese Academy of Sciences No. 32 Jiaochang Donglu, Kunming, Yunnan, 650223, P.R.China
Phone	+86 871 5195684	Zip Code	650223
Fax	+86 871 5195684	E-mail	zhengyt@mail.kiz.ac.cn

Education and Appointments：

2002-present	Full professor	Kunming Institute of Zoology, Chinese Academy of Sciences, China
2002-2003	Visiting Scholar	Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong
2000-2002	Professor and Director	Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, CAS
1994-2000	Associate Professor	Kunming Institute of Zoology, The Chinese Academy of Sciences
1996.8-10	Visiting Scholar	Hokkaido University and Gunma University School of Medicine, Japan
1993-1997	Ph. D. Student	Kunming Institute of Zoology, CAS
1991-1994	Assistant Professor	Kunming Institute of Zoology, CAS
1989-1991	Assistant	Kunming Institute of Zoology, CAS
1986-1989	MS student	Kunming Institute of Zoology, CAS
1983-1986	Assistant	Gannan Medical College, Ganzhou, Jiangxi, China
1978-1983	B.S.	Jiangxi Medical College, China

Research Interest：

More than 4000 purified compounds from animals, plants, and halobios were screened for anti-HIV-1 activity. Many natural lead compounds, such as xanthohumol (from the hop Humulus lupulus.), concentricolide (from Daldinia sp.), scutellarin (from Erigeron breviscapus (Van.) Hand–Mazz.), sulphated polyhydroxysterol (from the marine sponge Halichondria rugosa Ridley & Dendy), rutin sulphate (from Sophora japonica), trichobitacin (from the root tubers of Trichosanthes kirilowii), zinc complex of baicalin (baicalin extracted from the Chinese medicinal plant Scutellaria baicalensis), lectins (from marine invertebrates), maxinin (from the skin secretion of the Chinese red belly toad Bombina maxima.), the rare-earth compounds La(NO3)3.6H2O and Ce(NO3)3.6H2O), and the venom L-amino acid oxidase (TSV-LAO; from Trimeresurus stejnegeri) have shown strong anti-HIV activity. One of our main interests is to establish key technologies for anti-HIV drug screening in order to identify new anti-HIV drugs from chemical compounds or natural medicinal products. We are also interested in attaining our own patent rights to any of these compounds that we identify. The newly established NHP models would also facilitate future studies of HIV/SIV pathogenesis.
Our BSL-3 laboratory was built in 1995. Supported by the CAS and Kunming Institute of Zoology, we established one of the few ABSL-3 laboratories in 2003. HIV and SIV are related lentiviruses that cause a similar syndrome in their respective hosts. We have successfully infected Rhesus monkeys with SIV and SHIV. These and other non-human primate AIDS models are important for studying HIV/AIDS pathogenesis and for evaluating vaccines and anti-HIV drugs. We can now focus our research on anti-HIV drugs, vaccines, and HIV pathogenesis at the levels of cell and animal models.

Public Services：

Honors：

1.Zheng YT, Ben KL, et al. Patent NO: ZL 97 1 15693.X;

2.Zhang Y, Lai R, Zheng YT, Tan SZ, Lee WH. Preparation of protease inhibitor from Bombina maxima and its use in drug production. (Approved Patent Number: ZL00122416.6);

3. Zhang Y, Lai R, Zheng YT, Liu GJ, Lee WH, Tan SZ. Application of Bombina maxima peptides in anti-tumour and anti-AIDS drugs. (Approved Patent Number: ZL00122417.4);

4.Zhang Y, Lai R, Zheng YT, Tan SZ, Lee WH. Bombina maxima peptide preparation and its use in drug production (Approved Patent Number: ZL00122415.8);

5.Zhang Y, Lai R, Zheng YT, Lee WH. Preparation of an anti-sperm peptide from Bombina maxima and its use in drug production. (Approved Patent Number:ZL00130617.0); and

6.Zhang Y, Lai R, Zheng YT, Lee WH, Liu H, Liu GJ. Preparation of an anti-tumour protein and its gene (Approved Patent Number: ZL01107253.9)

Selected Publication：

1. Liu FL, Qiu YQ, Li H, Kuang YQ, Tang X, Cao G, Tang NLS and Zheng YT*. An HIV-1 resistance polymorphism in TRIM5 gene among Chinese intravenous drug users. J Acquir Immune Defic Syndr, 2011, 56: 306-311.
2. He YP, Long J, Zhang SS, Li C, Lai CC, Zhang CS, Li DX, Zhang DH, Wang H, Cai QQ, Zheng YT*. Synthesis and biological evaluation of novel dihydro-aryl/alkylsulfanyl- cyclohexylmethyl -oxopyrimidines (S-DACOs) as high active anti-HIV agents. Bioorg Med Chem Lett, 2011, 21: 694-697
3. Zhou YH, Liu FL, Yao ZH, Duo L, Li H, Sun Y, Zheng YT*. Comparison of HIV-, HBV-, HCV- and -co-infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region. PLoS One, 2011, 6(1): e16349
4. Li YY, Liu YQ, Yang LM, Wang RR, Pang W, Chen SW, Tian X, Zheng YT*. The Anti-HIV actions of 7- and 10-substituted camptothecins. Molecules, 2010, 15(1): 138-148 (Correction,15(1): 149-149)
5. Lin HW, Sun MX, Wang YH, Yang LM, Yang YR, Huang N, Xuan LJ, Xu YM, Bai DL, Zheng YT*, Xiao K. Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum. Planta Med. 2010, 76: 889-892
6. Ran JQ, Huang N(共同第一作者), Xu H, Yang LM, Lv M, Zheng YT*. Anti HIV-1 agents 5. Synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles in vitro. Bioorg Med Chem Lett. 2010, 20(12): 3534-3536
7. Zeng XW, Huang N(共同第一作者), Xu H, Yang WB, Yang LM, Qu H, Zheng YT*. Anti human immunodeficiency virus type 1 (HIV-1) agents 4. Discovery of 5,5´-(p-phenylenebisazo)-8-hydroxyquinoline sulfonates as new HIV-1 inhibitors in vitro. Chem Pharm Bull(Tokyo). 2010, 58(7): 976-979
8. Feng T, Wang RR, Cai XH, Zheng YT*, Luo XD. Anti-human immunodeficiency-1 constituents of the bark of Poncirus trifoliate. Chem Pharm Bull (Tokyo). 2010, 58(7): 971-975.
9. Sun Y, Ouyang DY, Pang W, Tu YQ, Li YY, Shen XM, Tam SC, Yang HY, Zheng YT*. Expression of syncytin in leukemia and lymphoma cells. Leukemia Res. 2010, 34:1195-1202
10. Law SK, Wang RR, Mak AN, Wong KB, Zheng YT*, Shaw PC. A switch-on mechanism to activate maize ribosome-inactivating protein for targeting HIV-infected cells. Nucleic Acids Res. 2010, 38(19): 6803-6812
11. Zhang XJ, Yang GY, Wang RR, Pu JX, Sun SD, Xiao WL, Zheng YT*. 7,8-secolignans from Schisandra wilsoniana and their anti-HIV-1 activities. Chem Biodivers, 2010, 7(11): 2692-2701
12. Xia HJ, Zhang GH, Ma JP, Dai ZX, Li SY, Han JB, Zheng YT*. Dendritic cell subsets dynamics and cytokine productions in SIVmac239 infected Chinese rhesus macaques. Retrovirology, 2010, 7: 102
13. Dai HL, Liu WQ(共同第一作者), Xu H, Yang LM, Lv M, Zheng YT*. Anti HIV-1 Agents 1. Discovery of Benzyl Phenyl Ethers as New HIV-1 Inhibitors in vitro. Chem Pharm Bull (Tokyo), 2009, 57(1): 84-6.
14. Senthilkumar P, Long J(共同第一作者), Swetha R, Shruthi V, Wang RR, Preethi S, Yogeeswari P, Zheng YT*, Sriram D. Synthesis of Zidovudine Derivatives with Anti-HIV-1 and Antibacterial Activities. Nucleosides Nucleotides Nucleic Acids, 2009, 28(2): 89-102
15. Luo DQ, Zhao LY, Shi YL, Tang HL, Li YY, Yang LM, Zheng YT*, Zhu HJ, Liu JK.Velleratretraol, an unusual highly functionalized lactarane sesquiterpen from Lactarius vellereus. J Antibiot (Tokyo). 2009, 62(3):129-32
16. Fan LL, Liu WQ, Xu H, Yang LM, Lv M, Zheng YT*. Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors in vitro. Lett Drug Des Discov, 2009, 6: 178-180
17. Wang RR, Yang LM, Wang YH, Pang W, Tam SC, Tien P, Zheng YT*. Sifuvirtide, a potent HIV fusion inhibitor peptide. Biochem Biophys Res Commun. 2009, 382: 540-544
18. Kuang YQ, Tang X, Liu FL, Jiang XL, Zhang YP, Gao GX, Zheng YT*.Genotyping of TRIM5 locus in Northern pig-tailed macaques (Macaca leonina), a primate species susceptible to human immunodeficiency virus type 1 infection. Retrovirology, 2009, 6(1): 58
19. Xia HJ, Liu HL, Zhang GH, Zheng YT*. Phenotype and function of myeloid dendritic cells derived from Chinese rhesus macaque blood monocytes. Cell Mol Immunol, 2009, 6(3): 159-165
20. Fan LL, Liu WQ(共同第一作者), Xu H, Yang LM, Lv M, Zheng YT*. Anti HIV-1 Agents 3. Synthesis and in vitro Anti-HIV-1 Activity of some N-Arylsulfonylindoles. Chem Pharm Bull (Tokyo), 2009, 57(8): 797-800.
21. Ma CH, Wang RR, Tian RR, Ye G, Fan MS, Zheng YT*, Huang CG. Calycosin 7-O-b-D-glucopyranoside, an Anti-HIV Agent from the Roots of Astragalus membranaceus VAR. mongholicus. Chem Nat Compd, 2009, 45(2): 282-285
22. Tu YQ, Wang MJ, Yao J, Zhu XM, Pan PL, Xing WG, Zhang GH, Yang RG, Zheng YT*, Jiang Y. Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China. Transfusion, 2009, 49(9): 1865-1873.
23. Pang W, Tam SC, Zheng YT*. Current peptide HIV type-1 fusion inhibitors. Antivir Chem Chemoth, 2009, 20(1): 1-18
24. Xia HJ, Zhang GH, Wang RR, Zheng YT*. The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. Cell Mol Immunol, 2009, 6(6): 433-440
25. Tang JG, Wang YH, Wang RR, Dong ZJ, Yang LM, Zheng YT *, Liu JK. Synthesis of analogues of flazin，in particular flazinamide, as promising anti-HIV agents. Chem Biodivers 2008, 5(3): 447-460
26. Wang RR, Gu Q, Wang YH, Zhang XM, Yang LM, Zhou J, Chen JJ, Zheng YT*. Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis. J. Ethnopharmacol. 2008, 117(2): 249-256
27. Xu H, Liu WQ, Fan LL, Chen Y, Yang LM, Lv L, Zheng YT*. Synthesis and HIV-1 Integrase Inhibition Activity of some N-Arylindoles. Chem Pharm Bull (Tokyo) 2008, 56(5): 720-722.
28. Pang W, Wang RR, Yang LM, Liu CM, Tien P, Zheng YT*. Recombinant protein of Heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro. Virology, 2008, 377(1): 80-87.
29. Rao ZK, Long J, Li C, Zhang SS, He M, Ou LC, Zheng YT*, He YP. Synthesis and anti-HIV-1 activity of S-dihydro(alkyloxy)benzyloxypyrimidine derivatives. Monatsh Chem, 2008, 139: 967-974
30. Ouyang DY, Xu LH, Dai ZX, Shi HJ, Zhang GH, Zheng YT*, He XH. Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques. Acta Bioch Bioph Sin (Shanghai), 2008, 40(11): 919-927.
31. Wang YH, Tang JG, Wang RR, Yang LM, Dong ZJ, Du L, Shen X, Liu JK, Zheng YT*. Flazinamide, a novel β-carboline compound with anti-HIV actions. Biochem. Biophys. Res. Commun. 2007, 355:1091-1095
32. Chen SW, Wang YH, Jin Y, Tian X, Zheng YT*, Luo DQ, Tu YQ. Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives. Bioorg Med Chem Lett. 2007, 17(7): 2091-2095
33. Cheng P, Jiang ZY, Wang RR, Zhang XM, Wang Q, Zheng YT *, Zhou J, Chen JJ. Synthesis and biological evaluation of N-acetyl-beta-aryl-1, 2-didehydroethylamines as new HIV-1 RT inhibitors in vitro. Bioorg Med Chem Lett. 2007, 17: 4476-4480
34. Liu GJ, Wang JP, Xiao JC, Zhao ZW, Zheng YT*. Preparation and characterization of three monoclonal antibodies against HIV-1 p24 capsid protein. Cell Mol Immunol. 2007, 4(3): 203-8
35. Liao CH, Kuang YQ, Liu HL, Zheng YT*, Su B. A novel fusion gene mnTRIMCyp in pig-tailed macaque determines its susceptibility to HIV-1 infection. AIDS. 2007, 21(Suppl 8): S19-S26
36. Wang JH, Kong J, Li W, Molchanova V, Chikalovets I, Belogorseva N, Luk'Yabov P,. Zheng YT *, A β-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity. Comp Biochem Phys C Toxicol Pharmacol. 2006, 142(1-2): 111-117
37. Qin XD, Dong ZJ, Liu JK, Yang LM, Wang RR, Zheng YT*, Lu Y, Wu YS, Zheng QT. Concentricolide, an anti-HIV agent from the Ascomycete Daldinia concentrica. Helvetica Chemica Acta, 2006, 89: 127-133
38. Wang RR, Gu Q, Yang LM, Chen JJ, Li SY, Zheng YT*. Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis. J. Ethnopharmacol. 2006, 105(1-2): 269-273
39. Liu HL, Wang YQ, Liao CH, Kuang YQ, Zheng YT*, Su B. Adaptive evolution of primate TRIM5α, a gene restricting HIV-1 infection. Gene. 2005, 362: 109-116

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