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| Title: |
Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues |
| First Author: |
Zhao, Yu; Zhang, Hong-Bin; Liu, Ji-Kai; Su, Jia; Li, Yan; Yao, Zhu-Jun; Zhao, Qin-Shi |
| Abstract: |
Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (BuOK)-Bu-t and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved. |
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| Page Number: |
139-142 |
| Issue: |
1 |
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| Impact Factor: |
2.538 |
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| PubYear: |
2011 |
| Volume: |
52 |
| Publication Name: |
TETRAHEDRON LETTERS |
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