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  100 Talents Program of Chinese Academy of Sciences
Heqing Shen
Highest Education:
1799 Jimei Road, Xiamen
Zip Code:

Education and Appointments:

04,2009-now Professor, Institute of Urban Environment, CAS.
04,2006-03,2009 Chemist (Cand. Sci.), University Department of Growth and Reproduction, Rigshospitalets, Copenhagen, Denmark;
02,2005-03,2006 Postdoctoral researcher, Institute for Ecological Chemistry, GSF-National Research Center for Environment and Health (Helmholtz Zentrum München - German Research Center for Environmental Health);
12,2001-02,2005 PhD student, Weihenstephan Center of Life and Food Sciences, Technical University Munich;
07,1997-09,2001 Lecturer, Department of Chemical Engineering, Dalian University for National Minorities;
09,1994-07,1997 Master of Science student, Dalian Institute of Chemical Physics, Chinese Academy of Sciences;
07,1991-08,1994 Technician., Coke and Gas Mill of Changzi, Shanxi Province;
09,1987-06,1991 Undergraduate student, Department of Applied Chemistry, Taiyuan University of Technology.

Research Interest:
The major areas are human exposure to the environmental pollutants, health effects and risk assessment. Many concerns on urban changing (urbanization) and health and wellbeing
1. Exposure Science: Human biological monitoring of micro-pollutants, esp., endocrine disrupting chemicals, food and environment monitoring, molecular exposomics, exposure biomarkers
2. Toxicology/Environmental Epidemiology: response biomarkers of pollutants, omics and systems biology, environmental epigenetic toxicology, environmental epidemiology
Selected Publications:

1.      Zhang J, Liu F, Chen R, Feng T, Dong S, Shen H*, Levels of Polychlorinated Biphenyls and Organochlorine Pesticides in Edible Shellfish from Xiamen (China) and Estimation of Human Dietary Intake. Food Chem. Toxicol. 2012, 50, 4285–4291

2.      Xu W, Bao H, Liu F, Liu L, Zhu Y-G, She J, Dong S, Cai M, Li L, Li C, Shen H*. Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study. Environ. Health 2012, 11:46

3.      Peng S, Zhang J*, Tian M, Wang Z, Shen H*. Determination of Global DNA Methylation in Biological Samples by Liquid Chromatography-Tandem Mass Spectrometer (液相色谱-串联质谱法测定生物样本全基因组DNA甲基化). Ch. J. Anal. Chem. 2012, 40 (8), 1201-1206

4.      Zhang J, Yan L, Tian M, Huang Q, Peng S, Dong S, Shen H*. The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. J. Pharm. Biomed. Anal. 2012, 66, 287-297

5.      Krysiak-Baltyn K, Skakkebæk NE, Toppari J, Jensen T, Virtanen H, Schramm K-W, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main K. Association between chemical pattern in breast milk and congenital cryptorchidism: modeling of complex human exposure. Int. J. Androl. 2012, 35 (3), 294-302

6.      Liu L, Xia T, Guo L, Cao L, Zhao B, Zhang J, Dong S, Shen H*. Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example. J. Expo. Sci. Environ. Epidemiol., 2012, 22, 625-631

7.      Peng S, Yan L, Zhang* J, Shen H*. Hepatotoxicity of perfluorooctanoic acid in human hepatocytes using metabonomics(利用代谢组学技术研究全氟辛酸的人肝脏毒性机制). Ch. J. Chromatogr. 2012, 30 (02): 123-127

8.      Tian M, Peng S, Martin FL, Zhang J, Liu L, Wang Z, Dong S, Shen H*. Perfluorooctanoic acid induces gene promoter hypermethylation of glutathione-S-transferase Pi in human liver L02 cells. Toxicology. 2012, 296 (1-3) 48-55

9.      Liao Y, Wang J, Huang Q, Fang C, Kiyama R, Shen H*, Dong S*. Evaluation of cellular response to perfluorooctane sulfonate in human umbilical vein endothelial cells. Toxicol. in Vitro 2012, 26(3): 421-428

10.  Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. Physiologically based persistent organic pollutant accumulation in pig tissues and their edible safety differences: An in vivo study. Food Chem. 2012,132 (4)1830-1835

11.  Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, Shen H*, Dong S*. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquatic Toxicol. 2011, 106-107, 9-19

12.  Shen H, Henkelmann B, Rambeck WA, Mayer R, Wehr U, Schramm K-W. The predictive power of the elimination of dioxin-like pollutants from pigs: An in vivo study. Environ. Int. 2012, 38 73-78

13.  Liu F, Ni H-G, Chen F, Luo Z-X, Shen H*, Liu L, Wu P. Metal accumulation in the tissues of grass carps (Ctenopharyngodon idellus) from fresh water around a copper mine in Southeast China. Environ. Monit. Assess. 2012, 184(7), 4289-4299

14.  Wang X, Suo Y, Yin R, Shen H*, Wang H*. Ultra-performance liquid chromatography/tandem mass spectrometry for accurate quantification of global DNA methylation in human sperms. J. Chromatogr. B. 2011, 879, 1647-1652

15.  Zhao B, Shen H*, Liu F, Liu S, Niu J, Guo F, Sun X. Exposure to organochlorine pesticides is independent risk factor of hepatocellular carcinoma: A case-control study, J. Expo. Sci. Environ. Epidemiol. 2012, 22, 541-548

16.  Liu L, Bao H, Liu F, Zhang J, Shen H*. Phthalates exposure of the Chinese reproductive age couples and their effect on male semen quality, a primary study. Environ. Int. 2012, 42,78-83

17.  Zhao B, Liu F, Liu S, Niu J, Guo F, Sun X, Shen H*. A case-control study of the association between human exposure to selected chlorinated pesticides and primary hepatocellular carcinoma. Epidemiology 2011, 22, S145

Before 2010

18.  Kristina Voigt, Rainer Brueggemann, Hagen Scherb, Heqing Shen, Karl-Werner Schramm. 2010. Evaluating the relationship between chemical exposure and cryptorchidism by discrete mathematical method using PyHasse software. Environ. Model. Softw. 25:1801-1812.

19.  İsmet Çok, Menekse Keski Donmez, Mine Uner, Erkan Demirkaya, Bernhard Henkelmann, Heqing Shen, Jarmila Kotalik, Karl-Werner Schramm. 2009. Polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls levels in human breast milk from different regions of Turkey. Chemosphere 76: 1563-1571.

20.  Konrad Krysiak-Baltyn, Niels Erik Skakkebæk, Jorma Toppari, Thomas Jensen, Helena Virtanen, Karl-Werner Schramm, Heqing Shen, Terttu Vartiainen, Hannu Kiviranta, Olivier Taboureau, Søren Brunak, Katharina Main. 2009. Country-specific chemical signatures of persistent environmental compounds in breast milk. Int. J. Androl. 32:1-9.

21.  Heqing Shen, Bernhard Henkelmann, Walkiria Levy, Adam Zsolnay, Peter Weiss, Gert Jakobi, Manfred Kirchner, Wolfgang Moche, Katharina Braun and Karl-Werner Schramm. 2009. Altitudinal and chiral signature of persistent organochlorine pesticides in air, soil, and spruce needles (Picea abies) of the Alps. Environ. Sci. Technol. 43:2450-2455.

22.  İsmet Çok, Menekse Keski Donmez, M. Hakan Satıroğlu, Batu Aydınuraz, Bernhard Henkelmann, Heqing Shen, Jarmila Kotalik, Karl-Werner Schramm. 2008. Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like PCBs in adipose tissue of infertile men. Arch. Environ. Contam. Toxicol. 55:143-152.

23.  Heqing Shen, Katharina M. Main, Anna-Maria Andersson, Ida N. Damgaard, Helena E. Virtanen, Niels E. Skakkebaek, Jorma Toppari, and Karl-Werner Schramm. 2008. Concentrations of persistent organochlorine compounds in human milk and placenta are higher in Denmark than in Finland. Hum. Reprod. 23:201-210.

24.  Heqing Shen, Katharina M Main, Helena E Virtanen, Ida N Damggard, Anne-Maarit Haavisto, M Kaleva, KA Boisen, Ida M Schmidt, Marla Chellakooty, Niels E Skakkebaek, Jorma Toppari, Karl-Werner Schramm. 2007. From mother to child: Investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring. Chemosphere 67:256-262.

25.  Mart Simm, Ott Roots, Jonne Kotta, Ain Lankov, Bernhard Henkelmann, Heqing Shen, Karl-Werner Schramm. 2006. PCDD/Fs in sprat (Sprattus sprattus balticus) from the gulf of Finland, the Baltic Sea. Chemosphere 65:1570-1575.

26.  Ida N Damgaard, Niels E Skakkebæk, Jorma Toppari, Helena E Virtanen, Heqing Shen, Karl-Werner Schramm, Jørgen H Petersen, Tina K Jensen, Katharina M Main and the Nordic Cryptorchidism. 2006. Study group, Persistent pesticides in human breast milk and Cryptorchidism. Environ. Health Persp. 114:1133-1138.

27.  Heqing Shen, H.E. Virtanen, Katharina M. Main, M. Kaleva, A.M. Andersson, Niels E. Skakkebæk, Jorma Toppari and Karl-Werner Schramm. 2006. Enantiomeric ratios as an indicator of exposure processes for persistent pollutants in human placentas. Chemosphere 62:390-395.

28.  H. Shen, K.M. Main, M. Kaleva, H. Virtanen, A.-M. Haavisto, N.E. Skakkebaek, J. Toppari and K.-W. Schramm. 2005. Prenatal organochlorine pesticides in placentas from Finland: Exposure of male infants born during 1997–2001. Placenta 26:512-514.

29.  Liangmo Zhou, Mengyan Nie, Qinghai Wang, Daoqian Zhu, Heqing Shen. 1999. Enthalpy-entropy compensation effect in gas chromatographic enantiomeric separation. Ch. J. Chem. 17:363-376.

30.  Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1999. A study of a molecular mechanics field used in simulating enantiorecognition. Ch. Chem. Letters 10:415-418.

31.  Duan Zhang, Zhanguo lu, Heqing Shen, Liangmo Zhou, Wenshen Guo. 1997. The asymmetrical reduction of 1-4’-hydroxyphenyl-1-butanone complexed with solid l-cedrol, Ch. J. Synthetic Chem, A5:559 .

32.  Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1998. Study of four pentylated α-, β-cyclodextrin chiral stationary phases on capillary gas chromatography. Ch. J. Anal. Chem. 26:211-214.

33.  Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1998. Study on 2,6-Dipentyl-β-cyclodextrin as a stationary phase in capillary gas chromatographic separation of enantiomers. J. Inst. Anal. 17:45-46.

Heqing Shen, Qinghai Wang, Daoqing Zhu, Liangmo Zhou. 1997. Molecular modeling method and its applications in chiral recognition mechanism. Ch. J. Anal. Chem. 25:110-114.

Supported Projects:

2012–2015 NSFC, Repoductive male exposure to perfluoroalkyl compounds and the association to DNA methylation in sperm (21177123) (PI)
2011-2013  Xiamen Science and Technology Foundation, Risk assessment of pregnancy and infant exposure to phthalates and the prevent research (3502Z20122003) (PI)
2009-2012  CAS 100 Talents Program for Human Exposure to Environmental Pollutant and Health Effect (PI)
2010-2012  CAS/SAFEA International Partnership Program for Creative Research Teams (KZCX2-YW-T08) (participant)
2009-2012  MOST for Combined Pollution and Ecosystem Health in Urban Agglomeration (2009DFB90120) (participant)
2010-2012  39th Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry: Pilot study of using gel diaper sampled urine for monitoring the infants exposure to endocrine disrupting chemicals (PI)
2011-2013  Knowledge Innovation Programs of Chinese Academy of Sciences, An integrated study of toxicology of PFOS and PFOA in the L02 cell line using metabonomics, proteomics, and transcriptomics platforms (KZCX2-EW-QN408) (participant)
2011-2013  Xiamen Science and Technology Foundation, Development and application of High-throughput screening technique for organic pollutants in milk and dairy products  (3502Z20112017) (participant)