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  Principal Investigators
Name:
WANG Yu
Subject:
Stem Cell and Regenerative Biology
Tel/Fax:
+86-10-82619461  / 
E-mail:
wangyuATioz.ac.cn (Please replace AT with @)
Address:
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, North West Ring Road, West 25-1 Rm. 302, Beijing 100190
More:
Group of stem cell and pharmacological modulation      
Resume:

Yu Wang, Ph.D., is a professor at the Institute of Zoology, Chinese Academy of Sciences. He received his bachelor degree from University of Science and Technology of China in 2004 and his Ph.D. from Harvard University in Department of Chemistry and Chemical Biology in 2010, under the supervision of Dr. Andrew P. McMahon. He subsequently worked as a postdoctoral fellow with Dr. Andrew P. McMahon and Dr. Lee L. Rubin at Harvard and later as a research associate with Dr. James A. Thomson at Morgridge Institute for Research. His work spans multiple areas, including cell biology and chemical biology studies on the Hedgehog signaling pathway, drug discovery for targeted cancer therapy and regenerative medicine, and stem cell based disease modeling and drug discovery. Some of it has been published in high profile journals including PNAS, JACS, ACS Chemical Biology, Chemistry & Biology, and Current Opinion in Cell Biology. He is also an inventor for 2 patents on screening technologies and small molecule drug leads.

Research Interests:
The application of stem cell technologies in drug development and the application of chemical biology approaches to study stem cell biology. 

Awards and Honors:

Professional Activities:

Research Grants:

Selected Publications:
  1. Wang Y*, McMahon AP, Allen BL*. (2007) Shifting paradigms in Hedgehog signaling. Current Opinion in Cell Biology. 19(2):159-65  Invited Review. *equal contribution.
  2. Zhou Z, Koglin A, Wang Y, McMahon AP, Walsh CT. (2008) An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. Journal of the American Chemical Society. 130(30):9925-30.
  3. Wang Y, Zhou Z , Walsh CT, McMahon AP. (2009) Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. The Proceedings of the National Academy of Sciences USA (PNAS). 106(8):2623-8.
  4. Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo J, Coy S, Rubin LL, McMahon AP.  (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation.  ACS Chemical Biology. 7(6):1040-8.
    --Featured in “Introducing Our Authors”. ACS Chemical Biology. 7(6): 939-42.
  5. Wang Y, Davidow L, Arvanites A, Blanchard J, Lam K,  Xu K, Oza V, Yoo J, Ng JM, Curran T, Rubin LL, McMahon AP.  (2012) Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity. Chemistry and Biology. 19:972-982.
    --Featured Article.

Patents:

  1. Wang Y and McMahon AP (2011). System for screening agonists/antagonists of cellular signaling pathways. US Patent 20,110,319,286 and WO Patent WO/2010/078,290
  2. Wang Y, McMahon AP, and Rubin LL (2012). Modulators of Hedgehog signaling pathway. PCT patent pending.