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Title: Population genomics reveals low genetic diversity and adaptation to hypoxia in snub-nosed monkeys
Author: Xuming Zhou①*, Xuehong Meng①, Zhijin Liu①, Jiang Chang①, Boshi Wang①, Mingzhou Li①, Pablo Orozco-terWengel, Shilin Tian, Changlong Wen, Ziming Wang, Paul A Garber, Huijuan Pan, Xinping Ye, Zuofu Xiang, Michael W. Bruford, Scott V. Edwards, Yinchuan Cao, Shuancang Yu, Lianju Gao, Zhisheng Cao, Guangjian Liu, Baoping Ren, Fanglei Shi, Zalan Peterfi, Dayong Li, Baoguo Li, Zhi Jiang, Junsheng Li, Vadim N. Gladyshev, Ruiqiang Li,*, Ming Li,*
Abstract: Snub-nosed monkeys (genus Rhinopithecus) are a group of endangered colobines endemic to South Asia. Here, we re-sequenced the whole genomes of 38 snub-nosed monkeys representing four species within this genus. By conducting population genomic analyses, we observed an similar load of deleterious variation in snub-nosed monkeys living in both smaller and larger populations and found that genomic diversity was lower than that reported in other primates. Reconstruction of Rhinopithecusevolutionary history suggested that episodes of climatic variation over the past 2 million years, associated with glacial advances and retreats and population isolation, have shaped snub-nosed monkey demography and evolution. We further identified several hypoxia-related genes under selection in R. bieti (black snub-nosed monkey), a species that exploits habitats higher than any other nonhuman primate. These results provide the first detailed and comprehensive genomic insights into genetic diversity, demography, genetic burden and adaptation in this radiation of endangered primates.
Corresponding author: Xuming Zhou, Ruiqiang Li, Ming Li,
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PubYear: 2016
Issue: DOI: 10.1093/molbev/msw150
Journal: Molecular Biology and Evolution
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URL: http://mbe.oxfordjournals.org/content/early/2016/07/17/molbev.msw150.abstract