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姓 名: |
霍波 |
性 别: |
男 |
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职 务: |
无 |
职 称: |
副研究员 |
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学 历: |
博士 |
通讯地址: |
北京市北四环西路15号， 中国科学院力学研究所国家微重力实验室，100190 |
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电 话: |
100190 |
邮政编码: |
100190 |
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传 真: |
010-82544130 |
电子邮件: |
无 |
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| 简历： |
2002-今，副研究员，中科院力学所微重力室
2006-2008，博士后，美国哥伦比亚大学生物医学工程系骨生物工程实验室
2000-2002，博士后，清华大学材料科学与工程系生物材料室
1996-2000，博士，清华大学工程力学系固体力学专业
1993-1996，硕士，北京航空航天大学飞行器设计与应用力学系
1989-1993，本科，北京航空航天大学飞行器设计与应用力学系 |
| 研究领域： |
| My research interests are mainly focused on the prediction of macroscopic mechanical properties of biological tissues, such as tooth, bone and skeletal muscle, basing on their microstructures. The structural and material properties at the various scales of atoms, molecules and tissues will be integrated by theoretically modelling (e.g. statistical mechanics, chemical reaction dynamics and micromechanics). Then the prediction can be verified by using some experimental methods, e.g. nanoindentation and digital speckle correlation method, which can measure the mechanical properties of the samples with small sizes and heterogeneities. Numerical computation (e.g. finite element method) is also a strong means of the prediction. Another field I interest in very much is the correlation between the mechanical properties, conformations and amino acid sequences of biological molecules. Now I study silk protein as model molecule. The mechanical properties of single molecules can be measured by means of AFM and optical tweezer. Molecular modelling and some theoretical methods basing on statistical mechanics can be used to clarify the correlation. |
| 代表论著： |
1.Huo B, Lu XL, Hung CT, Costa KD, Xu Q, Whitesides GM, 2008. Fluid flow induced calcium response in bone cell network. Cellular and Molecular Bioengineering, 1: 58-66. (Cover Figure)
2.Huang T, Ren P, Huo B, 2007. Atomic force microscopy observations of the topography of regenerated silk fibroin aggregations. Journal of Applied Polymer Sciences, 106: 4054-4059.
3.章燕，叶志义，霍波，孙淦云，龙勉．2005．应用光阱技术测量P-selectin/PSGL-1键解离的断裂力．生物医学工程学杂志，第22卷，第5期：961-965.
4.Huo B, 2005. An inhomogeneous and anisotropic constitutive model of human dentin. Journal of Biomechanics, 38:587-594.
5.张清，王嘉德，霍波，2003. 楔状缺损充填治疗后牙颈部硬组织应力分析. 中华口腔医学杂志，v38，n4，264-265
6.霍波, 翟勇, 崔福斋, 2002. 蚕丝中蛋白构象含量与其力学性质间的关系. 高分子学报, n3, 261-264 7.Huo B, Zheng QS, 2002. Effect of dentin tubules on the mechanical properties of dentin. Part III: Numerical verification. Acta Mechanica Sinica, 18(6): 629-637.
8.Huo B, Zheng QS, Zhang Q, Wang JD, 2000. Effect of dentin tubules on the mechanical properties of dentin. Part II: Experimental study. Acta Mechanica Sinica, 16(1): 75-82.
9.Huo B, Zheng QS, 1999. Effect of dentin tubules on the mechanical properties of dentin. Part I: Stress-strain relations and strength criterion. Acta Mechanica Sinica, 15(4): 355-364.
10.Huo B, Zheng QS, Huang Y, 1999. A note on the effect of surface energy and void size to void growth and cavitation instability. European Journal of Mechanics, 18: 987-994. |
| 承担科研项目情况： |
| 自然科学基金面上项目（青年，30300076），“蚕丝蛋白凝胶成丝过程中构象转变的机理”，2004.1-2006.12 |
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