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姓 名:
 殷战
性 别:
 男
职 称:
 研究员
学 历:
 研究生
电 话:
 86-27-68780069
电子邮件:
 zyin@ihb.ac.cn

简历:

博士,研究员,博士生导师。中国科学院水生生物研究所研究所所长助理、所学术委员会副主任。

教育经历:1986年毕业于武汉大学生物系;1989年在中国科学院水生生物所获得硕士学位;1999年在新加坡国立大学生物系获得博士学位。  

工作和培训经历:1989-1994年任水生所助理研究员; 1999-2003年在美国Case Western Reserve University医学院药学系做博士后研究;2003-2005年在美国University of Pennsylvania医学院医学系分子心脏病学研究中心做博士后研究;20055月至今,中科院水生生物研究所研究员。 

 

20055月回到中国科学院水生生物研究所组建学科组以来,开展了鱼类内分泌对生长、肌肉发育等方面调控机制的研究工作。目前主要以斑马鱼为主要研究模式,并结合鲫鱼为养殖模式,集中关注鱼类的内分泌生长调控轴、在鱼类营养、代谢、生长、繁殖等方面的内分泌调控研究方面,开展了较为系统地研究工作。并在采用基因编辑技术和遗传标记辅助育种方面,针对模式鱼类和养殖鱼类的代谢调控、肌肉生长、可控性鱼类性腺发育技术研究等方面也正在取得许多深具潜力的研究进展。对利用斑马鱼为模式生物系统的环境内分泌干扰物评价体内模式也曾进行了一系列有益的探索。 


研究方向:

发育生物学,鱼类生长发育、代谢调控及繁殖过程的内分泌调控机制  


专家类别:
百人;杰青;万人计划

职务:

社会任职:

获奖及荣誉:

2006年获中国科学院"百人计划"择优资助; 2009年获得国家杰出青年科学基金资助。2016年第二批国家“万人计划”领军人才。 

代表论著:

1.        Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., He, J., Zhang, Y., Yin, Z.* . 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25 (OH) 2 D 3. Cell Reports. 19:1444-1455.

2.        Zhai, G., Song, J., Shu, T., Yan, J., Jin, X., He, J., Yin, Z*. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics (In press)

3.        Dai, X., Shu, Y., Lou, Q., Tian, Q., Zhai, G., Song, J., Lu, S., Yu, H., He, J., Yin, Z. * 2017. Tdrd12 Is Essential for Germ Cell Development Maintenance in Zebrafish. International Journal of Molecular Sciences. 18(6), 1127;

4.        Yang, J., Li Z., Gan, X., Zhai, G., Gao, J., Xiong, C., Qiu, X., Wang, X., Yin, Z.*, Zheng, F.* 2016.  Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences. 17(11), 1746.

5.        Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q and Yin Z* 2016. Depletion of Myostatin b Promotes somatic growth and lipid Metabolism in Zebrafsh.  Frontier in Endocrinology. 7:88.

6.        Zhai, G., Shu, T., Xia, Y., Jin, X., He, J., Yin Z. * 2016. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A.  Science Bulletin. 62 (3), 197-203.

7.        Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W.*, Yin, Z*. 2016. The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models  Scientific Reports. 6, Article number: 18597

8.        Dai X, Jin X, Chen X, He J, Yin Z*. 2015.  Sufficient numbers of early germ cells are essential for female sex development in zebrafish. PLoS One. 2015 Feb 13;10(2):e0117824.

9.        Dai X, Zhang W, Zhuo Z, He J, Yin Z*. 2015. Neuroendocrine regulation of somatic growth in fishes (Review). Science in China Life Science. 58(2):137-47. Review.

10.    Cheng,X., Chen,X., Li, D., Jin, X., He, J., Yin Z*. 2015. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. General and Comparative Endocrinology. 21487-94.

11.    Cheng, X., Chen, X., Jin, X., He, J., Yin, Z*. 2014. Generation and Characterization of Gsuα:EGFP Transgenic Zebrafish for Evaluating Endocrine-Disrupting Effects. Toxicology and Applied Pharmacology. 278(1): 78-84.  

12.    He, W., Dai, X., Chen, X., He, J., Yin, Z*. 2014. Zebrafish Pituitary Gene Expression Before and After Sexual Maturation. Journal of Endocrinology. 221(3):429-440.  

13.    Li, D., Lou, Q., Zhai, G., Peng, X., Cheng, X., Dai, X., Zhuo, Z., Shang, G., Jin, X., Chen, X., Han, D., He, J., Yin, Z.* 2014. Hyperplasia and Cellularity Changes in IGF-1-Overexpressing Skeletal Muscle of Crucian Carp. Endocrinology. 155 (6)2199-2212.  

14.    Zhai, G., Gu, Q., He, J., Lou, Q., Chen, X., Jin, X., Bi, E.*, Yin, Z.* 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development. Molecular and Cellular Biology. 34(7): 1310-1321.  

15.    Mei Y, Yin N, Jin X, He J, Yin Z* 2013. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9.

16.    Chen D, Li L, Tu X, Yin Z*, Wang Q*. 2013. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis. Human Molecular Genetics. 22(5):963-76.

17.    Cui X, Zhang, J., Du, R., Wang, L., Archacki, S., Zhang, Y., Yuan, M., Ke, T., Li, H., Li, D., Li, C., Li, DW., Tang, Z., Yin, Z*., Liu, M*. HSF4 is involved in DNA damage repair through regulation of Rad51. Biochimica et Biophysica Acta-Molecular Basis of Diseases. 1822(8):1308-15.

18.    Ji C., Jin X., He J.,Yin, Z*. 2012. Use of TSHbeta:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicology and Applied Pharmacology. 262(2):149-155

19.    Jiang N., Jin X., He J., Yin Z*. 2012 The Roles of follistatin 1 in Regulation of Zebrafish Fecundity and Sexual Differentiation. Biology of Reproduction. 87 (3) 54, 1-8.

20.    Chen X., Lou Q., He J. & Yin Z*. 2012. Role of Zebrafish Lbx2 in Embryonic Lateral Line Development. PLoS ONE 6(12): e29515.

21.    Lou Q., He J., Hu L., Yin Z*. 2012. Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish. Biochimica et Biophysica Acta - Molecular Cell Research. 823(5):1024-32.

22.    Li X., He J., Hu W & Yin Z * 2009. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 150(6):2767-74.

23.    Ma L., Li D., Wang J., He J & Yin Z * 2009. Effects of Adrenergic Agonists on the Extrahepatic Expression of Vitellogenin Ao1 in Heart and Brain of the Chinese Rare Minnow (Gobiocypris rarus). Aquatic Toxicology. 91 (1): 19-25.

24.    Trivedi CM*, Luo Y*, Yin Z*, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. 2007. HDAC2 regulates the cardiac fetal gene program and hypertrophic responsiveness by modulating GSK3ß. Nature Medicine. 13(3): 324-331. (*Equal first author).

25.    Yin, Z.*, Gonzales, L*., Kolla, V., Rath, N., Zhang, Y., Lu, MM., Kimura, S., Ballard, PL., Beers, MF., Epstein, JA. & Morrisey, EE. 2006. Hop functions downstream of Nkx2.1 and Gata6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. American Journal of Physiology, Lung Cellular and Molecular Physiology. 291L191-199. (*Equal first author)

26.    Yin, Z., Jeni Haynie, Bryan R. Williams and Yu-Chung Yang. 2003. C114 is a novel IL-11-inducible nuclear dsRNA-binding protein that inhibits Protein Kinase R. Journal of Biological Chemistry. 278, 22838-22845.

27.    Yin, Z. Haynie, J., Yang, X.,. Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., Hoit, B. D., Watanabe, M and Yu-Chung Yang. 2002. The essential role of Cited2, a negative regulator hif-1 in heart development and neurulation. Proceedings of National Academy of Sciences of the United States of America. 99, 10488-10493.

 

 

Last updated on June 20th, 2017

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