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 Jianyun Wang, Professor

Biography & Introduction

2007-current Professor, Institute of Biophysics, Chinese Academy of Sciences

2003-2007 Postdoctoral training, Dept. of Chemistry (Advisor: Prof. Peter G. Schultz) The Scripps Research Institute

1998-2003 Ph.D., Dept. of Chemistry (Advisor: Prof. Kenneth S. Suslick) Univ. of Illinois at Urbana-Champaign

1994-1998 B.S., Dept. of Special Class for Gifted Young (Advisor: Prof. Zuyao Chen) Univ. of Science and Technology of China

Metalloenzymes catalyze some of the most challenging reactions, such as the conversion of H2O to O2, O2 to H2O, N2 to NH3 and H+ to H2, under mild physiological conditions. As these reactions are of tremendous importance for energy production and green chemistry, they are currently intensively investigated by biophysical chemists. However, these metalloenzymes are usually huge membrane protein complexes, and are hard to produce in large amount for performing biochemical studies, and are difficult to engineer to suit for industrial applications. The central aim in our laboratory is to use small, soluble protein scaffold, and the genetic incorporation of unnatural amino acid to design easy-to-characterize, easy-to-produce, and easy-to-optimize metalloenzymes which catalyze these important reactions with equal or greater efficiency/selectivity than that of the natural systems.

Visit my Group Page Here >>>  http://www.sciencenet.cn/blog/wangyou.htm

Recent Selected Publications(as a Correspondence Author)

1. Li, F. H.; Shi P.; Li J. S.;Yang F.; Wang T. Y.; Zhang W.; Gao F.; Ding W.; Li D.; Li J.; Xiong Y.;  Sun J. P.; Gong W. M.; Tian C. L.; Wang J. Y., “A Genetically Encoded 19F NMR Sensor for Tyrosine Phosphorylation ” Angew. Chem. Intl. Ed. 2013, 52, 3958-62. (Hot article and Back Cover Article)

2. Zhou Q.; Hu M. R.; Zhang W.; Jiang, L.; Perrett S.; Zhou J.; Wang J. Y., “Probing the Function of the Tyr-Cys Crosslink in Metalloenzymes through the Genetic Incorporation of 3-Methylthiotyrosine” Angew. Chem. Intl. Ed. 2013, 52, 1203-7.

3. Liu, X. H.; Yu, Y.; Hu, C.; Zhang, W.; Lu, Y.; Wang, J. Y, “Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase” Angew. Chem. Intl. Ed. 2012, 51 , 4312-6. (News of the Week, Chemical and Engineering News)

4. Liu, X. H.; Li, J. S.; Dong, J. S.; Hu , C.; Gong, W. M.; Wang, J. Y.,  “Genetic Incorporation of a Metal Chelating Amino Acid as a Probe for Protein Electron Transfer” Angew. Chem. Intl. Ed. 2012, 51, 10261-5. (Very Important Paper and Cover Article)

5. Yu, Z.; Pan, Y. C.; Wang. Z. Y.; Wang, J. Y.; Lin. Q., “Genetically Encoded Cyclopropene Directs Rapid, Photoclick Chemistry- Mediated Protein Labeling in Mammalian Cells” Angew. Chem. Intl. Ed. 2012, 51,10600-4.

6. Wang, J. Y.; Zhang, W.; Song, W. J.; Wang, Y. Z.; Yu, Z. P.; Li, J. S.; Wu, M. H.; Wang, L.; Zang, J. Y.; Lin, Q., “A Biosynthetic Route to Photoclick Chemistry on Proteins” J. Am. Chem. Soc. 2010, 132, 14812-8.

7. Liu, X. H.; Li J. S.; Hu C.; Zhang W.; Hu M. R.; Zhou J.; Wang J. Y., “Significant Expansion of the Fluorescent Protein Chromophore through the Genetic Incorporation of an  Metal-chelating Unnatural Amino Acid” Angew. Chem. Intl. Ed. 2013, 52, 4805-9

8. Li, F. H.; Zhang, H.; Sun, Y.; Pan, Y. C.; Zhou, J. Z.; Wang, J. Y., “Expanding the Genetic Code for Photoclick Chemistry in E. coli, Mammalian Cells and A. thaliana”  Angew. Chem. Intl. Ed. 2013 DOI: 10.1002/anie. 201303477


E-mail  jwang(AT)ibp.ac.cn (请将(AT)替换为@,防止垃圾邮件)




Postalcode  100101