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专家类别: 研究员
简历 & 研究组工作摘要：
1992-1997，北京医科大学临床医学学士
1997-2002，中国协和医科大学理学博士
2002-2008，美国ST JUDE儿童研究医院博士后
2009至今，中国科学院生物物理研究所研究员
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Biography & Introduction
EDUCATION
1997-2002 Ph.D., Genetics
Department of Medical Genetics
Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
1992-1997 M.D., Medicine
Department of Clinical Medicine, School of Medicine
Beijing Medical University, Beijing, China
2009-Present Professor, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Research direction: Establishing animal research center in IBP, including transgene and gene targeting core facility in IBP.
2002-2008 Postdoctoral Research Associate, St. Jude Children’s Research Hospital, Memphis, TN, USA
Research direction: Studying mouse models of human genetic diseases.
2000-2001 Ph.D., co-supervised by Department of Clinical Genetics, Erasmus University, Rotterdam, the Netherlands
1997-2002 Ph.D., supervised by Department of Medical Genetics, Peking Union Medical College& Chinese Academy of Medical Sciences, Beijing, China
Research direction: Human genetic disease gene mapping and positional cloning.
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Selected Publications
1. Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, L?wenheim H, Samarut J, Engel J, Knipper M. Deafness in TRbeta mutants is caused by malformation of the tectorial membrane. J Neurosci. 2009 Feb 25;29(8):2581-7.
2. Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E and Jackowski S. Cytokine Secretion Requires Phosphatidylcholine Synthesis. J Cell Biol. 2008 Jun;181(6):945-57.
3. Gunter C, Frank M, Tian Y, Murti KG, Rehg JE, Jackowski S. Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice. Biochim Biophys Acta. 2007 Jul;1771(7):845-52.
4. Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews DB, Zakharenko SS, Liberman MC, Zuo J. Orphan glutamate receptor delta1 subunit required for high-frequency hearing. Mol Cell Biol. 2007 Jun;27(12):4500-12.
5. Tian Y, Zhou R, Rehg JE, Jackowski S. Role of phosphocholine cytidylyltransferase alpha in lung development. Mol Cell Biol. 2007 Feb;27(3):975-82.
6. Tian Y, Jackson P, Gunter C, Wang J, Rock CO, Jackowski S.Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.J Biol Chem. 2006 Sep 22;281(38):28438-49.
7. Chow LM, Tian Y, Weber T, Corbett M, Zuo J, Baker SJ. Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn. 2006 Nov;235(11):2991-8.
8. Tian Y, James S, Zuo J, Fritzsch B, Beisel KW. Conditional and inducible gene recombineering in the mouse inner ear. Brain Res. 2006 May 26;1091(1):243-54.
9. Tian Y, Li M, Fritzsch B, Zuo J. Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Dev Dyn. 2004 Sep; 231(1): 199-203.
10. Li M*, Tian Y*, Fritzsch B, Gao J, Wu X, Zuo J. Inner hair cell Cre-expressing transgenic mouse. Genesis. 2004 Jul; 39(3): 173-7. (Co-first author)
11. Tian Y, Breedveld GJ, Huang S, Oostra BA, Heutink P, Lo WH. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. Biochim Biophys Acta. 2002 Aug 19; 1577(1): 121-5.
12. Zhao H*, Tian Y*, Breedveld G, Huang S, Zou Y, Y J, Chai J, Li H, Li M, Oostra BA, Lo WH, Heutink P. Postaxial polydactyly type A/B (PAP-A/B) is linked to chromosome 19p13.1-13.2 in a Chinese kindred. Eur J Hum Genet. 2002 Mar; 10(3): 162-6.
13. Tian Y, Zhao H, Chen J, Liu Y, Li M, Yang T, Luo H, Huang S. Cloning of a novel zinc finger gene ZNF333 and its expression analysis. Basic Medical Sciences and Clinics. 2002; 22(3): 232-235 (In Chinese)
14. Tian Y, Huang S. Current advances in genetic analysis of hereditary spastic paraplegia. Foreign Medical Sciences. 2000; 23 (4): 182-185 (In Chinese)
ACADEMIC SOCIETY AWARD
2007 Best Poster Award for ASBMB ANNUAL MEETING, WASHINGTON, D.C.
(ASBMB: American Society for Biochemistry and Molecular Biology)
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