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专家类别: 院士,研究员
简历 & 研究组工作摘要：
1960年苏联莫斯科大学生物系获哲学博士(Ph.D)学位。
1982年至今生物物理研究所研究员，曾任中国科学院生物物理所副所长，生物大分子国家重点实验室学术委员会主任。
1991年当选为中国科学院学部委员。
现任生物大分子国家重点实验室名誉主任。
现任Bioscience Reports, Magnesium Research, Journal of Biochem.,Mol. Biol. & Biophysics, 《中国科学C辑》，《中国生化与分子生物学报》和《分子细胞生物学报》等十种国内外学术期刊编委。
曾先后获国家自然科学奖，中国科学院自然科学奖、科技进步奖、卫生部科技进步奖等多项奖励。
长期从事生物膜（尤其是线粒体膜）膜脂－膜蛋白相互作用的研究。重点关注以下问题：
1、“脂筏”中膜脂—膜蛋白相互作用的研究，例如鞘脂类和/或胆固醇对细胞质膜 Ca2+ ATPase 构象与活性的影响。
2、细胞凋亡溶酶体－线粒体途径的膜脂－膜蛋白相互作用研究。
3、电子晶体学方法研究膜蛋白及其复合物的三维结构的研究。
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Biography & Introduction
Prof. Yang Fuyu, senior research scientist, 1960 Ph.D in Mossow Univ. He had served the Institute of Biophysics, CAS as deputy director and chairman of the Academic Council of the National Lab of Biomacromolecules. He was elected as a member of CAS in 1991.
Our group has long been involved in the studies of lipid-protein interaction of biomembranes (including mitochondrial membranes).
1. Study on the lipid-protein interaction in the lipid raft, for instance, effect of sphingolipids and/or cholesterol on the conformation and activity of plasma membrane Ca2+-ATPase (PMCA).
2. Study on the lipid-protein interaction in the "Lysosome-mitochondria pathway"to apoptosis.
3. An attached group headed by Dr. Zhang Xujia is dealing with the determination of 3D structure of membrane proteins or its complex by electron crystallography.
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Selected Publications：
1. 克山病与心肌线粒体病(综述)中国科学C辑481-485 杨福愉 2006
2. Yang FY, Keshan Disease and Mitochondrial Cardiomyopathy* , (Minireview) 2006, 49(6)513-518
* In memory of 20th Anniversary of the accomplishment of comprehensive scientific survey (1984-1986) of Keshan disease in Chuxiong region.
3. Li CL, Duan WJ, Yang FY, Zhang XJ, Caveolin-3-anchored microdomains at the rabbit sarcoplasmic reticulum membranes, 2006, BIOCHEM BIOPHYS RES COMMUN, 344(4): 1135-1140
4. Duan JF, Zhang J, Zhao YF, Yang FY, Zhang XJ, Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its 'receptor' 2006, ARCH BIOCHEM BIOPHYS 454(2): 155-159
5. Zhao YF, Fan XX, Zhang XJ and Yang FY. Gangliosides modulates the plasma membrane Ca2+-ATPase from porcine brain synaptosomes. ARCH BIOCHEM BIOPHYS 427, 204-212 (2004).
Yan L, Miao, Sun Y and Yang FY. T Bid forms a pore in the liposome membrane. FEBS LETT 555, 545-550 (2003).
6. Ouyang YS, Tu YP, Baiker, SA and Yang FY. Regulators of G-protein Singnaling (RGS)4, Insertion into Model Membranes and Inhibition of Activity by Phosphatidic acid. J BIOL CHEM . 278(13), 11115-11122 (2003).
7. Miao Q, Han XH and Yang FY. Phosphatidic acid-phosphatidylethanolamine interaction and apocytochrome c translocation across model membranes. BIOCHEM J 354: 681-688 (2001).
8.Yang FY and Huang F. Effect of non-bilager lipids on the activity of membrane enzymes (Review). CHEM PHYS LIPIDS 81, 197-202 (1996).
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