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专家类别: 院士,研究员
简历 & 研究组工作摘要:
1964年,毕业于中国科技大学生物物理系
1978-1980年,吉林大学理论化学进修班学习
1985-1987年,获洪堡奖学金在德国纽伦堡大学从事量子生物学研究
1994-2003年,作为访问学者或访问教授先后在香港中文大学;美国加州洛杉矶大学;美国哈佛大学;日本大阪大学蛋白质研究所;台湾理论科学中心等从事合作研究。
1989年至今,生物物理研究所 研究员
2007年11月,当选中国科学院院士
现为国际人类基因组组织(HUGO)会员;国际数据库组织(CODATA)生物大分子专业组委员。国际纯粹及应用物理学会(IUPAP)生物信息学专业委员会委员;国际学术期刊《Journal of Theoretical Biology》的编委
陈润生院士是我国最早从事理论生物学和生物信息学研究的科研人员之一。二十多年来在生物信息学领域进行了系统的研究,曾参加我国第一个完整基因组泉生热袍菌B4基因组序列的组装和基因标识,曾参加人类基因组1%和水稻基因组工作草图的研究。共发表SCI学术论文120余篇,自1996年以来在国际学术会议上共作大会报告及分组会报告二十余次。由于其在基因组信息学领域的早期工作,1996年 9月29日至10月3日在日本筑波召开的第十五届国际科学技术数据委员会(CODATA)大会上应邀作"Kotani Memorial Lecture",同时获得“小谷正雄”奖 ("Kotani Prize",生物领域)
Biography & Introduction
1964: Graduated from Department of Biophysics, University of Science and Technology of China (USTC)
1978-1980: Postgraduate: Institute of Theoretical Chemistry, Jilin University
1985.6-1987.8: Institute for Theoretical Chemistry, University Erlangen-Nurnberg, FRG, as a Fellow of Alexander von Humboldt Foundation.
1994-2003: Dept. of Statistics, the Chinese University of Hong Kong; Interdivisional Program in Statistics, the University of California at Los Angeles (UCLA); Department of Biostatistics, Harvard University; Institute of Protein Research, Osaka University, Japan; National Center for Theoretical Sciences, Taiwan; as a Visiting Scholar or Visiting Professor.
Professor Runsheng Chen is one of the pioneer scholars developing the researches on theoretical biology and bioinformatics in China. For more than twenty years, Prof. Chen has led his group to perform a series of systemic researches in the field of bioinformatics, including the whole genome assembly and annotation for T. tengcongensis B4 (the first bacterium genome completely sequenced in China), the 1% Human Genome Project, and the Draft Sequence of the Rice Genome. So far, Prof. Chen has published more than 120 papers in SCI, and made more than 20 conference or group reports in the international academic conferences since 1996. For his outstanding early studies on genomic informatics, Prof. Chen was invited to give the "Kotani Memorial Lecture" on the 15th International CODATA Conference, Tsukuba, Japan, 29 Sep. - Oct. 1996, and then selected as the winner of "Kotani Prize"
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Selected Publications:
1. Wang Y, Chen J, Wei G, He H, Zhu X, Xiao T, Yuan J, Dong B, He S, Skogerbø G, Chen R. The Caenorhabditis elegans intermediate-size transcriptome shows high degree of stage-specific expression. Nucleic Acids Res,2011,39(12),5203-14
2. He SM, Su H, Liu CN, Skogerbo G, He HS, He DD, Zhu XP, Liu T, Zhao Y, Chen RS*. MicroRNA-encoding long non-coding RNAs. BMC Genomics 2008, 9:236.
3. HS He, J Wang, T Liu, XS Liu, TT Li, YF Wang, ZW Qian, HX Zheng, XP Zhu, T Wu, BC Shi, W Deng, W Zhou, G Skogerb? and RS Chen, Mapping the C. elegans noncoding transcriptome with a whole-genome tiling microarray,GENOME RES , 2007,17(10):1471-1477.
4. SM He, CN Liu, G Skogerb? HT Zhao, J Wang, T Liu, BY Bai, Y Zhao and RS Chen,NONCODE v2.0: decoding the non-coding, Nucleic Acids Res, 2007, 1-3.doi:10.1093/nar/gkm1011.
5. Sun H, Skogerbo G, Chen RS, Conserved distances between vertebrate highly conserved elements, HUM MOL GEN 2006,5(19): 2911-2922 .
6. Zhang ZH, Liu CN, Skogerbo G, Zhu X, Lu H, Chen L, Shi B, Zhang Y, Wang J, Wu T, Chen R, Dynamic changes in subgraph preference profiles of crucial transcription factors PLOS COMPUT BIO, 2006, 2(5): 383-391 .
7. Deng W, Zhu XP, Skogerbo G,………, Chen R. Organization of the Caenorhabditis elegans small non-coding transcriptome: Genomic features, biogenesis, and expression. GENome RES, 2006,16 (1): 20-29 .
8. Yong Zhang, Zhihua Zhang, Lunjiang Ling, Baochen Shi and Runsheng Chen. Conservation analysis of small RNA genes in Escherichia coli. BIOINFORMATICS 20, 599-603 (2004).
9. Dongbo Bu, Yi Zhao, Lun Cai, Hong Xue, Xiaopeng Zhu, Hongchao Lu, Jingfen Zhang, Shiwei Sun, Lunjiang Ling, Nan Zhang, Guojie Li and Runsheng Chen, Topological structure analysis of the protein-protein interaction network in budding yeast. NUCLEIC ACIDS RES 31(9), 2443-2450 (2003).
10.Qiyu Bao,……, Runsheng Chen ,……, Huanming Yang. A Complete Sequence of the Themoanaerobacter tengcongensis Genome. GENOME RES 12, 689-700 (2002).
11.J.Yu,……., R.S.Chen,……H.M.Yang. A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. Indica). Science 296, 79-92 (2002).
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