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专家类别: 院士,研究员
简历 & 研究组工作摘要：
1963年毕业于中国科学技术大学，后分配至中国科学院生物物理研究所工作至今
1986年晋升为研究员，博士生导师
1982-1984年作为Humboldt研究员留学德国马-普生化所
1988年作为Wellcome研究员客座英国约克大学
2005年当选为中国科学院院士
曾任中国科学院生物物理研究所副所长，中国生物物理学会副理事长，中国科学院生物物理研究所分子生物学研究中心主任
现任中国晶体学会副理事长，生物大分子晶体学专业委员会主任，中国科学院生物物理研究所学位委员会主席，《中国科学-生命科学辑》主编,《生物化学与生物物理进展》主编。
主要从事蛋白质的结构、功能和基于结构的分子改造研究。运用X-射线晶体结构分析方法研究一些重要蛋白质/复合物的三维结构及其与生物功能的关系，并以此为基础结合可能的医药应用开展相关蛋白质工程研究。近年主要研究一系列来自动物、植物和微生物的天然防御和感染致病相关蛋白质的结构与功能，包括天然神经毒素，抗肿瘤蛋白，抗病毒蛋白，抗真菌蛋白，发现一系列新结构新机理。通过系统性研究，测定东亚钳蝎钠离子通道毒素的代表性三维结构，发现毒素分子的活性部位，阐明其神经毒性的主要结构基础，揭示通过特定肽键“顺-反式异构”调控活性的特殊机理及其分子开关。发现抗肿瘤蛋白AAL促使肿瘤细胞凋亡的结构机理。通过天然抗真菌蛋白特殊单体结构的研究揭示决定其活性特征的“寡聚组装”机理。测定革兰氏阴性菌三型分泌系统关键SpvC的三维结构，阐明其阻断宿主天然免疫应答致病的分子机理。目前重点研究感染与免疫中一些重要蛋白质及复合物的结构与功能，包括肿瘤发生和抑制相关蛋白（如脑海绵状血管瘤发生相关蛋白及复合物），病原微生物感染相关重要蛋白质及其致病通路中的效应蛋白（如幽门螺旋杆菌四型分泌系统中的相关蛋白）。
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Biography & Introduction
Graduated from the Chinese University of Science and Technology on 1963, then has been working in the Institute of Biophysics, CAS. 1986 was promoted to be the full Professor.1982-1984 worked in Max-Planck Institute for Biochemistry at Munich of Germany as a Humboldt Research Fellow; 1988 worked in York University, England as a Wellcome Trust Research Fellow. Had been a deputy director of the Institute, Chief of the Center for Molecular Biology, and Vice President of the Chinese Society of Biophysics. Currently being the Vice President of the Chinese Society of Crystallography and the Chief of Biomacromolecule Committee, Editor-in-Chief of Science in China: Life Sciences， Progress in Biochemistry and Biophysics.
Elected Member of the Chinese Academy of Sciences since 2005.
The group is mainly engaged in structural biology studies on some important proteins involved in the innate defense and pathogenesis, including natural neurotoxin, anti-tumor protein, antifungal protein and antiviral protein from animal, plant and microbe. The studies revealed a series of novel structures and elucidated some unique structural mechanisms for their function performance. In studies on the sodium channel toxin from East Asia scorpion we determined the representative 3D structures, found the active site and the main structural basis for the toxicity, and discovered a molecular switch with a unique “ cis/trans peptide conversion” and its structural mechanism for the functional ramification to mammal/insect. We also elucidated the structural mechanism for tumor cell apoptosis of anti-tumor protein AAL; revealed the “oligomeric assembly mechanism” governing the biological ramification of antifungal protein gastrodianin, and the structure and mechanism of the pathogenic MAPK phosphothreonin Lyase SpvC, a novel protein effecter from Salmonella.
Currently the group focused on structure and function of some critical proteins in pathogen infection and tumor genesis, including the type IV secrete system from Helicobactor pylori, protein CCM3 and complex related to cerebral cavernous malformation.
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Selected Publications：
1. Yang N, Li DF, Feng L, Lin W, Sun H, Wang DC, Structural basis for the tumor cell apoptosis-inclucing activity of an antitumorlection from the Edible mushroom Agrocybe aegerite, J. Mol. Biol., 2009, 387:694-705
2. Yonglin Hu, Chengpeng Fan, Guangsen Fu, Deyu Zhu, Qi Jin and Da-Cheng Wang, Crystal Structure of a Glutamate/Aspartate Binding Protein Complexed with a Glutamate Molecule: Structural Basis of Ligand Specificity at Atomic Resolution, J. Mol. Biol., 2008, 382:99-11.
3. Zhu YQ, Li HT, Long CZ, Hu LY, Xu H, Liu LP, Chen S, Wang DC, Shao F. Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase. MOLECULAR CELL,2007, 28:899-913.
4. Zhu YQ, Zhu DY, Yin L, Zhang Y, Vonrhein C, Wang DC. Crystal structure of human spermidine/spermine N'-acetyltransferase (hSSAT): The first structure of a new sequence family of transferase homologous superfamily. PROTEINS, 2006, 63:1127-1131.
5. Li-Hui Liu, Frank Bosmans, Chantal Maertens, Ron-Han Zhu, Da-Cheng Wang and Jan Tytgat, Molecular basis of the mammalian potency of the scorpion α-like toxin, BmK M1, FASEB J., Express article, 2005, 19:594-596.
6. Wei Liu, Na Yang, Jingjin Ding, Ren-huai Huang, Zhong Hu and Da-Cheng Wang, Structural mechanism governing the quaternary organization of monocot mannose-binding lectin revealed by the novel monomeric structure of an orchid lectin, J. Biol. Chem., 2005, 28:14865-14876.
7. Xiang Ye, Frank Bosmans, Chong Li, Ying Zhang, Da-Cheng Wang, and Jan Tytgat, Structural Basis of Voltage-gated Na+ Channel Selectivity of the Scorpion α-like Toxin BmK M1, J. Mol. Biol., 2005, 353;788-803.
8. Sun Y-M, Bosmans F, Zhu R-H, Xiong Y-M, Jan Tytgat and Wang D-C. Importance of the conserved aromatic residues in the scorpion α-like toxin BmK M1: the hydrophobic surface region revisited, J. Biol. Chem., 2004,278, 24125-24131.
9. Rong-Jin Guan, Ye Xiang, Xiao-Lin He, Chun-Guang Wang, Miao Wang, Ying Zhang, Eric J. Sundberg and Da-Cheng Wang, Structural Mechanism Governing Cis and Trans Isomeric States and an Intramolecular Switch for Cis/Trans Isomerization of a Non-Proline Peptide Bond Observed in Crystal Structures of Scorpion Toxins, J. Mol. Biol., 2004, 341:1180-1204.
10. Dapeng Zhou, Jochen Mattner, Carlos Cantu III, Nicolas Schrantz, Ning Yin, Ying Gao, Yuval Sagiv, Kelly Hudspeth, Yun-ping Wu, Tadashi Yamashita, Susann Teneberg, Da-Cheng Wang, Richard L. Proia, Steven B Levery, Paul B. Savage, Luc Teyton, Albert Bendelac, Lysosomal glycosphingolipid recognition by NKT cells, Science, 2004, 306: 1786-11789.
11. Xiang Y, Huang RH, Liu XZ, Zhang Y, Wang DC, Crystal structure of a novel antifungal protein distinct with five disulfide bridges from Eucommia olmoides Oliver, J. Struct. Biology, 2004, 148, 846-947.
12. He XL, L, HM, Zeng ZH, Liu XQ, Wang M, Wang DC, Crystal structures of two a-like scorpion toxins: Non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel, J. Mol. Biol., 1999, 292:125-135.
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