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专家类别: 院士,研究员
简历 & 研究组工作摘要：
1965年 毕业于莫斯科大学生物物理专业
1979年 获慕尼黑大学自然科学博士
1982－1984年 德国马克斯-普朗克生物控制论研究所访问学者
1988年至今 生物物理研究所研究员
2003年 当选中国科学院院士
现任“973”项目<脑结构与功能的可塑性研究>首席科学家(2006-2011)
研究方向：从基因－脑－行为－认知相结合的角度，研究果蝇的学习、记忆、注意和抉择和其他高级认知活动，并以果蝇为模式动物,研究神经退行性疾病的分子/细胞机制。
他的实验室开创了果蝇的基于价值的两难抉择研究；发现果蝇中央脑中的蘑菇体结构和多巴胺系统共同掌控果蝇的基于价值的抉择。发现了经验可以提升果蝇的视觉特征抽提能力以及果蝇中央脑的一个叫蘑菇体的结构参与上述的认知过程。
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Biography & Introduction
1960-1965 Dept. Of Biophysics, Moscow University, (USSR).
1977-1979 Dr.rer.nat. Munich University, Germany
1982-1984 Visiting Scientist (Max-Planck Institute for Biological Cybernetics, Germany)
1988- Research Professor, Institute of Biophysics, CAS.
2003- Academician of the Chinese Academy of Sciences
2006-2011 Principal Scientist for the "973" Program Project "Plasticity in Brain Structure and Function"
Main Research Interest and Recent Progress (06-07)
His Lab currently is mainly focusing on leaning/ memory and high level cognition in Drosophila. His long term goal is to explore the primary events of high level cognitive activities in Drosophila brain from evolutional point of view, to shed new light on brain-mind relationship.
Recently, his Lab discovered a simple value 朾ased decision-making behavior in Drosophila facing competing visual cues at flight simulator and found that Dopamine-Mushroom body circuit regulate decision-making process in Drosophila (Science 2007). His Lab also found that previous experience can enhance visual feature extraction among combinatorial features and that MBs are required for this experience-dependent visual cognition (J. Neurosci,2007).
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Selected Publications：
Zhang K, Guo JZ, Peng Y, Xi W, Guo A. Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila. SCIENCE, 2007, 316(5833): 1901-1904
Peng Y, Xi W, Zhang W, Zhang K, Guo A. Experience improves feature extraction in Drosophila. J NEUROSCI, 2007, 27(19): 5139-5145
Chen X, Li Y, Huang J, Cao D, Yang G, Liu W, Lu H, Guo A. Study of tauopathies by comparing Drosophila and human tau in Drosophila. CELL TISSUE RES, 2007, 329(1): 169-178
Peng YQ, Guo A. Novel stimulus-induced calcium efflux in Drosophila mushroom bodies, EURO J NEUROSCI, 2007, 25(7): 2034-2044
Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo A. Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. GENES BRAIN BEHAV, 2007, 5(8): 602-613
Yan Li 1,2, TongLiu 2, Yueqing Peng 2, Chunyan Yuan 2, and Aike Guo . Specific functions of Drosophila Amyloid Precursor-like Protein in the Development of Nervous and Non-nervous System. J NEUROBIOL, (2004).
Ye Yizhou, Xi Wang, Peng Yueqing,Wang Yizheng, Guo Aike. Long-term, but not short-term blockade of dopamine release in Drosophila impairs orientation during flight in a visual attention paradigm. EUR J NUTR, (2004).
Tang Shiming & Aike Guo. Choice behavior of Drosophila facing contradictory visual cues. SCIENCE 294, 1543-1547 (2001).
Yu Dinghui，Feng Chungua, Guo Aike. Altered Outward K Currents in Drosophila Larval Neurons of memory Mutants rutabaga and amnesiac. J NEUROBIOL 40(2), 158-171 (1999).
Guo A.K., Goetz K.G.. Association of visual objects and olfactory cues in Drosophila. LEARN MEMORY 4, 192-205 (1997).
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