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生物物理所人才库
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李雪梅研究员
Xuemei Li, Professor
 

专家类别: 研究员

简历&研究组工作摘要(Biography & Introduction):

Professor of  Institute of Biophysics,Chinese Acadmy of Science.

Xuemei Li is mainly engaged in the study of the three-dimensional structures of significant proteins related to human disease or with important physiological functions, as well as in proteomics,now especially working on the function and structure of HBV and AIV mianly protein.To date she has published more than 10 papers in international scientific journals such as Protein Science, J.Viol , Nat Struct Mol Biol and so on. 

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Biography & Introduction

Professor of  Institute of Biophysics,Chinese Acadmy of Science.

Xuemei Li is mainly engaged in the study of the three-dimensional structures of significant proteins related to human disease or with important physiological functions, as well as in proteomics,now especially working on the function and structure of HBV and AIV mianly protein.To date she has published more than 10 papers in international scientific journals such as Protein Science, J.Viol , Nat Struct Mol Biol and so on. 

Visit my Group Page Here >>>

Selected Publications

1. Sheng Cao1§, Zhiyong Lou2§, Ming Tan3, Yutao Chen1, Yijin Liu1, Zhushan Zhang1, Xuejun C. Zhang1,4, Xi Jiang3*, Xuemei Li1*, and Zihe Rao1,2.(2007). Structural Basis for the Recognition of Blood Group Trisaccharides by Norovirus. J.Viol. 81(11):5949-5957.

2. HaoWu, Lei Sun, Stan J. J. Brouns, Sheng Fu, Jasper Akerboom, Xuemei Li* and John van der Oost Purification, crystallization and preliminary crystallographic analysis of a GTP-binding protein fromthe hyperthermophilic archaeon Sulfolobus solfataricus. (2007). Acta Cryst. F63, 239–241.

3. Xuemei Li, Xuqi Liu, Yiwei Liu & Zihe Rao. 2004.Crystal structure of human coactosin-like protein at 1.9 angstrom resolution. Protein Science . 13:2845–2851.

4. Xuemei Li, Xueqi Liu & Zihe Rao. Crystallization and preliminary crystallographic studies of human coactosin-like protein (HSBP1). Acta Cryst., D. 2004. D60, 2387–2388 .

5. Xia Huo1,2, Dan Su1, Aojin Wang2, Yujia Zhai2, Jianxing Xu2, Xuemei Li2, Mark Bartlam1,2,Fei Sun2 and Zihe Rao1,.(2007). Preliminary molecular characterization and crystallization of mitochondrial respiratory complex II from porcine heart. FEBS J. Mar;274(6):1524-9.

6. Guangyu Zhu1, Jia Chen2, Jay Liu3, Joseph S. Brunzelle4, Bo Huang2, Nancy Wakeham1, Simon Terzyan1, Xuemei Li2, Guangpu Li3, Zihe Rao2, and Xuejun C. Zhang1,2*.(2007) Structure of APPL1 BAR-PH Domain and its Interaction with Rab5.(2007).EMBO.J.26, 3484-3493 .

7. Wei Zheng1, Fei Sun2, Mark Bartlam1,2, Xuemei Li2, Ran Li1, and Zihe Rao1,2. (2006).The crystal structure of human isopentenyl diphosphate isomerase at 1.7 angstrom resolution reveals its catalytic mechanism in isoprenoid biosynthesis. J Mol Biol. 366(5):1447-58.

8. Ou X, Ji C, Han X, Zhao X, Li X, Mao Y, Wong LL, Bartlam M & Rao Z*. 2006. Crystal  Structures of Human Glycerol 3-phosphate Dehydrogenase 1 (GPD1). J Mol Biol., 357(3):858-869

9. Yujia Zhai, Fei Sun, Xuemei Li, Hai Pang, Xiaoling Xu, Mark Bartlam & Zihe Rao.Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer. Nat Struct Mol Biol. 2005 Nov;12(11):980-6

10. Yuna Sun, Xuemei Li, Beili Wu, Ping Sun & Zihe Rao. Crystallization and Preliminary Crystallographic Analysis of Human Eukaryotic Translation Initiation Factor 5A (eIF-5A). Protein and Peptide Letters, 2005, Vol. 12, No. 7:1- 3

11. Liu B, Li X, Gao R, Zhou W, Xie G, Bartlam M, Pang H, Feng Y, Rao Z. Crystallization and preliminary X-ray analysis of inorganic pyrophosphatase from the hyperthermophilic archaeon Pyrococcus horikoshii OT3.Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):577-9.

12. Sun L, Li X, Dong Y, Yang M, Liu Y, Han X, Zhang X, Pang H, Rao Z. Crystallization and preliminary crystallographic analysis of human serine dehydratase.Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2297-9

13. Zeng Q, Li X, M Bartlam, Wang G, Pang H * & Rao Z*. 2003. Purification, crystallization and preliminary X-ray analysis of human Pirin. Acta Cryst., D. 2003 Aug;59(Pt 8):1496-8

14. Li T, Li X, Yang W, Rao Z, Zhai Zh.Crystallization of the N-terminal domain of dff45: the mutual chaperone mechanism is challenged. Protein Pept Lett. 2003 Apr;10(2):221-5 

联系方式(Contact): 

电子邮件(E-mail )  Lixm(AT)sun5.ibp.ac.cn

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