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专家类别: 院士,研究员
简历 & 研究组工作摘要：
饶子和，中国科学院院士，第三世界科学院院士。现任南开大学校长，中科院生物物理研究所学术委员会主任，中国科协常委，中国生物物理学会理事长，国际纯粹与应用生物物理联合会(IUPAB )理事会执行理事。
主要从事与重要病毒和肿瘤相关的蛋白质结构、功能以及创新药物的研究，在艾滋病毒、流感病毒、肝炎病毒和SARS病毒蛋白结构和抗病毒药物研究方面取得了一系列创新性的成果，在国际重要学术刊物上发表学术论文190余篇。其中仅2006-2007年期间在国际学术刊物上发表论文40篇，申请发明专利5项，获得发明专利2项。2006年饶子和院士因在线粒体膜蛋白复合物Ⅱ的三维精细结构的突破性的研究成果，荣获“陈嘉庚生命科学奖”；又因在SARS基础研究中的卓越贡献而获得第三世界科学院最高奖——“的里雅斯特科学奖”。
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Biography & Introduction
Zihe Rao is a Member of the Chinese Academy of Sciences and a Member of the Third World Academy of Science. He is currently the incumbent President of Nankai University; Director of the Academic Committee of the Institute of Biophysics, Chinese Academy of Sciences; a member of the standing committee of the China Association for Science and Technology; President of the Biophysical Society of China; and a member of the Executive Committee of the International Union for Pure and Applied Biophysics (IUPAB).
We are mainly engaged in the structure, function and drug discovery studies targeting important viral and tumor related proteins. We have produced a series of innovative results in the discovery of anti-viral compounds against HIV, the influenza virus, hepatitis virus and the SARS coronavirus. We have amassed a total of 190 publications important international academic journals. In the period from 2006-2007, 40 papers were published, 5 innovation patents were applied for and 2 national innovation patents were granted. In 2006, Zihe Rao was the recipient of the Chen Jiageng Prize for Life Sciences in recognition of his work on the crystal structure of the mitochondrial respiratory membrane protein complex II. In the same year, he was awarded the Trieste Science Prize for Medical Science by the Third World Academy of Science, in honour of his remarkable achievements in SARS basic research.
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Selected Publications：
Li Z, Huang Y, Ge J, Fan H, Zhou X, Li S, Bartlam M, Wang H, Rao Z The crystal structure of MCAT from Mycobacterium tuberculosis reveals three new catalytic models 2007, J Mol Biol. 371(4):1075-83
Xue X, Yang H, Shen W, Zhao Q, Li J, Yang K, Chen C, Jin Y, Bartlam M, Rao Z. Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction, 2007, J Mol Biol. 366(3):965-75
Liu Z, Lin H, Ye S, Liu QY, Meng Z, Zhang CM, Xia Y, Margoliash E, Rao Z, Liu XJ. Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis. 2006, Proc Natl Acad Sci USA. 103(24):8965-70
Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10, 2006 J Virol. 80(16):7902-8
Sun F, Huo X, Zhai YJ, Wang AJ, Xu JX, Su D, Bartlam M & Rao Z*. 2005. Crystal Structure of Mitochondrial Respiratory Membrane Protein Comples Ⅱ. Cell, 121: 1043-1057
Yang H, Xie WQ, Xue XY, Yang KL, Ma J, Liang WX, Zhao Q, Zhou Z, Pei DQ, J. Ziebuhr, R. Hilgenfeld, K. Y. Yuen, Wong L., Gao GX, Chen SJ, Chen Z, Ma DW, Bartlam M & Rao Z*. 2005. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biology, 3(10):e324, 1742-1752
Zhai Y, Sun F, Li X, Pang H, Bartlam M & Rao Z*. 2005. Structural insights into coronavirus transcription/replication from the crystal structure of the SARS-CoV hexadecameric nsp7-nsp8 super-complex. Nature Structural & Molecular Biology, 12(11): 980-986
Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B & Rao Z*. 2004. 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex. Proc Natl Acad Sci USA., 101(22):8348-8353
Bartlam M, Wang G, Yang H, Gao R, Zhao X, Xie G, Cao S, Feng Y & Rao Z*. 2004. Crystal Structure of an Acylpeptide Hydrolase/Esterase from Aeropyrum pernix K1. Structure, 12(8):1481-1488
Xu Y, Liu Y, Lou Z, Qin L, Bai Z, Pang H, Tien P, Gao G* & Rao Z*. 2004. Structural basis for coronavirus-mediated membrane fusion: Crystal structure of mouse hepatitis virus spike protein fusion core. J Biol Chem., 279 (29): 30514-30522
Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao G.F & Rao Z*. 2004. Crystal structure of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Fusion Core*. J Biol Chem., 279(47): 49414-49419
Yang H, Yang M, Ding Y, Liu Y, Lou Z, Sun L, Zhou Z, Ye S, Pang H, Gao G, Anand K, Bartlam M, Hilgenfeld R & Rao Z*. 2003. The Crystal Structures of SARS Virus Main Protease Mpro and Its Complex with an Inhibitor. Proc Natl Acad Sci USA., 100(23): 13190-13195
Ding Y, Xu G, Yang M, Yao M, George F. Gao, Wang L, Zhang W & Rao Z*. 2003. Crystal structure of the ectodomain of human FcalphaRI. J Biol Chem., 278 (30): 27966-27970 (cover)
Ding Y, Xu M, I Ghosh, Chen Xi, S. Ferrandon, G. Lesage & Rao Z*. 2003. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem., 278(40): 39133 - 39142
Rao Z, Belyaev A, Fry E, Jones I, Roy P＆Stuart D. 1995. Crystal Structure of SIV Matrix Antigen and its Implications for Virus Assembly. Nature，378(6558): 743-747
Rao Z, Handford P, Mayhew M, Knott V, Brownlee G＆Stuart D. 1995. The Structure of a Calcium Binding Epidermal Growth Factor-like Domain - its Role in Protein-Protein Interactions. Cell, 82(1): 131-141
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