Yuling Jiao, Ph.D.
Principal Investigator
Education
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2001 |
B.S. Peking University, Beijing, China
Biochemistry & Molecular Biology |
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2003 |
M.S. Yale University, New Haven, Connecticut, USA
Molecular, Cellular & Developmental Biology |
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2006 |
Ph.D. Yale University, New Haven, Connecticut, USA
Molecular, Cellular & Developmental Biology |
Professional Experience
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2006-2010 |
Postdoctoral Scholar with Dr. Elliot M. Meyerowitz, Division of Biology, California Institute of Technology, Pasadena, California, USA |
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2010- |
Principal Investigator, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China |
Selected Academic Honors
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2005 |
Chinese Government Award for Outstanding Students Abroad |
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2007 |
John Spangler Nicholas Prize for Outstanding Doctoral Candidate in Biology, Yale University |
Research Interests/Areas
| 1. Axillary meristem initiation and control of plant architecture. Plant architecture, and consequently yield for crops, is largely controlled by the initiation and outgrowth of axillary meristems (AM) in higher plants. Axillary shoot meristems develop from stem cells in the adaxial side of the subtending leaf axil and give rise to branches by forming new shoot apical meristems. We combine genetic analysis, transcriptome analysis, and live imaging to understand mechanisms underlying the initiation of AM, especially the orchestration of phytohormones. Understanding AM initiation may help in the elucidation of stem cell maintenance and differentiation, a long lasting question in biology. |
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| 2. Cell type-specific transcriptome profiling. The development and function of plant tissues relies on constant interactions among distinct and nonequivalent cell types. To understand how cells work and how they interface with the environment, it is essential to acquire quantitative information on transcriptomes at cellular resolution. We have developed novel high-throughput technologies to profile cell-specific transcriptome and translatome, i.e. all translating transcripts. Using flower development as a model system, we attempt to profile key cell types at high spatiotemporal resolution. A cell transcriptome atlas can aid in the formulation and validation of interaction and pathway networks by providing evidence of the coexpression of potential pathway members and by identifying new connections among regulatory genes. |
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Publications
Original Research
1.Jiao, Y. and Meyerowitz, E.M. (2010). Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control. Mol. Syst. Biol. 6: 419.
2.Sugimoto, K., Jiao, Y. and Meyerowitz, E.M. (2010). Arabidopsis regeneration from multiple tissues occurs via a root development pathway. Dev. Cell 18: 463-471.
Selected for Faculty of 1000 Biology.
3.Jiao, Y., Tausta, S.L., Gandotra, N., Sun, N., Liu, T., Clay, N.K., Ceserani, T., Chen, M., Ma, L., Holford, M., Zhang, H.-y., Zhao, H., Deng, X.-W. and Nelson, T. (2009). A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies. Nat. Genet. 41: 258-263.
Selected for Faculty of 1000 Biology.
4.Jiao, Y., Riechmann, J.L. and Meyerowitz, E.M. (2008). Transcriptome-wide analysis of uncapped mRNAs in Arabidopsis reveals regulation of mRNA degradation. Plant Cell 20: 2571-2585.
Highlighted with an In Brief article in Plant Cell 20: 2545;
Selected for Faculty of 1000 Biology.
5.Zhou, J., Wang, X., Jiao, Y., Qin, Y., Liu, X., He, K., Chen, C., Ma, L., Wang, J., Xiong, L., Zhang, Q., Fan, L. and Deng, X.W. (2007). Global genome expression analysis of rice in response to drought and high-salinity stresses in shoot, flag leaf, and panicle. Plant Mol. Biol. 63: 591-608.
6.Jiao, Y. and Deng, X.W. (2007). A genome-wide transcriptional activity survey of rice transposable element-related genes. Genome Biol. 8: R28.
7.Su, N., He, K., Jiao, Y., Chen, C., Zhou, J., Li, L., Bai, S., Li, X. and Deng, X.W. (2007). Distinct reorganization of the genome transcription associates with organogenesis of somatic embryo, shoots, and roots in rice. Plant Mol. Biol. 63: 337-349.
8.Jiao, Y., Ma, L., Strickland, E. and Deng X.W. (2005). Conservation and divergence of light-regulated genome expression patterns during seedling development in rice and Arabidopsis. Plant Cell 17: 3239-3256.
9.Ma, L., Chen, C., Liu, X., Jiao, Y., Su, N., Li, L., Wang, X., Cao, M., Sun, N., Zhang, X., Bao, J., Li, J., Pedersen, S., Bolund, L., Zhao, H., Yuan, L., Wong, G.K.-S., Wang, J., Deng, X.W. and Wang, J. (2005). A microarray analysis of the rice transcriptome and its comparison to Arabidopsis. Genome Res. 15: 1274-1283.
Selected for Faculty of 1000 Biology.
10.Jiao, Y., Jia, P., Wang, X., Su, N., Yu. S., Zhang, D., Ma, L., Feng, Q., Jin, Z., Li, L., Xue, Y., Cheng, Z., Zhao, H., Han, B. and Deng, X.W. (2005). A tiling microarray expression analysis of rice chromosome 4 suggests a chromosome-level regulation of transcription. Plant Cell 17: 1641-1657.
Featured on the cover.
11.Ma, L., Sun, N., Liu, X., Jiao, Y., Zhao, H. and Deng, X.W. (2005). Organ-specific expression of Arabidopsis genome during development. Plant Physiol. 138: 80-91.
12.Jiao, Y., Yang, H., Ma, L., Sun, N., Yu, H., Liu, T., Gao, Y., Gu, H., Chen, Z. Wada, M., Gerstein, M., Zhao, H., Qu, L.-J. and Deng X.W. (2003). A genome-wide analysis of blue-light regulation of Arabidopsis transcription factor gene expression during seedling development. Plant Physiol. 133: 1480-1493.
Reviews
1.Jiao, Y. and Riechmann, J.L. (2011). Transcriptome-wide analysis of uncapped mRNAs. Methods Mol. Biol. Invited review in preparation.
2.Nelson, T., Tausta, S.L., Gandotra, N., Liu, T., Ceserani, T., Chen, M., Jiao, Y., Ma, L., Deng, X.-W., Sun, N., Holfold, M., Li, N. and Zhao, H. (2008). The promise of systems biology for deciphering the control of C4 leaf development: transcriptome profiling of leaf cell types. In: Charting New Pathways To C4 Rice, J.E. Sheehy, P.L. Mitchell and B. Hardy, eds., World Scientific, pp. 317-332.
3.Jiao, Y., Lau, O.S. and Deng, X.W. (2007). Light-regulated transcriptional networks in higher plants. Nat. Rev. Genet. 8: 217-230.
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