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  Location: Home >> Faculty >> Molecular Agrobiology
  Molecular Agrobiology

Fangpu Han

Education and Professional Training


2004-2008, postdoctoral research fellow and research scientist, University of Missouri-Columbia, USA

2001-2004, Visiting fellow and biologist, Agriculture and Agri-Food Canada.

1998-2001, Postdoctoral Fellow, The Weizmann Institute of Sciences, Israel.

1995-1998, Ph.D. Northeast Normal University, Changchun, China

Research interests/area:


My laboratory will work on the plant chromosome biology, the research projects: 1) wheat chromosome engineering and genome evolution, 2) plant centromere structure and function, 3) molecular mechanism of plant meiosis, 4) plant artificial chromosome and specific genome modification.

Selected Recent Publications:


1. Han F, Gao Z and Birchler J. 2009.Centromere inactivation and reactivation reveal both genetic and epigenetic components for centromere specification. The Plant Cell, 21:1929-1939.


2. Birchler J and Han F. 2009. Maize Centromeres: Structure, Function and Epigenetics, Ann Review of Genetics, 43:287-305


3. Birchler J, Gao Z and Han F. 2009. Pairing in Plant: import is important. Proc. Natl. Acad. Sci. USA, in press.


4. Han F, Gao Z, Yu W, and Birchler J. 2007. Minichromosome analysis of chromosome pairing, disjunction and cohesion in maize. The Plant Cell, 19:3853-3863.


5. Han F, Lamb J, Yu W, Gao Z and Birchler J. 2007. Centromere function and nondisjunction are independent components of the maize B chromosome accumulation mechanism. The Plant Cell, 19: 524-533.


6. Han F, Lamb J and Birchler J. 2006. High frequency of centromere inactivation resulting in stable dicentric chromosomes of maize. Proc. Natl. Acad. Sci. USA, 103: 3238-3243.


7. Birchler J, Yu, W and Han F. 2008. Plant Engineered minichromosomes and artificial chromosome platforms. Cytogenet Genome Res, 120: 228-232.


8. Birchler, J, Gao, Z and Han F. 2008. A tale of two centromeres?diversity of structure but conservation of function in plants and animals. Function & Integrative Genomics, 104: DOI: 10.1007/s10142-008-0104-9


9. Yu W, Lamb J, Han F and Birchler J. 2007. Cytological visualization of DNA transposons and their transposition pattern in somatic cells of maize. Genetics, 175, 31-39.


10. Yu W, Han F, Vega J, Gao Z and Birchler J. 2007.Construction and behavior of engineered minichromosome in maize. Proc. Natl. Acad. Sci. U S A, 104: 8924-8929.


11. Vega J, Yu W, Han F, Kato A, Peters E and Birchler J. 2008. Placement of Cre-lox site-specific recombination cassette in the maize genome by Agrobacterium-mediated gene transformation with a BIBAC vector system. Plant Molecular Biology, 66: 587-598.


12. Yu W, Han F and Birchler J. 2007. Engineered minichromosomes in plant. Current Opinion in Biotechnology, 18: 425-431.


13. Yu W, Lamb J, Han F and Birchler J. 2006. Telomere-associated chromosomal truncation in maize. Proc. Natl. Acad. Sci. U S A, 103: 17331-17336.


14. Han F, Fedak G, Guo W and Liu B. 2005. Rapid and repeatable elimination of a parental genomic specific DNA (pGc1R-1a) in newly synthesized wheat allopolyploids. Genetics, 170: 1239-1245.


15. Han F, Fedak G, Ouellet T, Dan H and Somers D. 2005. Mapping of genes expressed in Fusarium graminearum-infected heads of wheat cultivar ‘Frontana’. Genome. 48(1): 88-96.


16. Han F, Liu B, Fedak G and Liu Z. 2004. Chromosomal variation, constitution of five partial amphiploids of wheat-Thinopyrum intermedium detected by GISH, seed storage protein marker and multicolor GISH. Theoretical Applied Genetics, 109: 1070-1076


17. Han F, Liu Z, Tan M, Hao S, Fedak G and Liu B. 2004. Mobilized endogeneous retrotransposon Tos17 of rice by alien DNA introgression transposes into genes and causes heritable alteration in structure and cytosine methylation status of a flanking genomic region. Hereditas, 141: 243-251.