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  Location: Home >> Faculty >> Developmental Biology
  Developmental Biology

Runlin Ma

B.S. 1982. Shihezi University, China. Plant Biology
M.S. 1987. University of Minnesota. USA, Insect Biochemistry
Ph.D. 1991. Kansas State University. USA, Insect Biochemistry


1990  Roger C. Smith Scholarship, Kansas State University, USA.

1992  International Conference Travel Award, National Science Foundation, USA.

1998  Member of the Hundred Talent Program, Chinese Academy of Sciences, China.

2001  Outstanding youth Scholarship of China, National Natural Science Foundation of China.

2004  Member of 'Bai-qian-wan' talented people program, jointly selected by Ministries of Personal Affairs, Education, Science & Technology, and National Natural Science Foundation of China.



2002  Professor and PI, Institute of Genetics and Developmental Biology,
Chinese Academy of Sciences, China

2001  Research Assistant Professor, College of Medicine, University of Cincinnati

1997  Research Assistant Professor, College of Veterinary Medicine University of Illinois at Urbana-Champaign

1991  Postdoctoral Research Associate, University of Illinois at Urbana-Champaign

1982  Lecture, Shihezi University, Xinjiang, China

1975  State farm worker, No 182 State Farm, Xinjiang, China



American Association for the Advancement of Science

International Society for Animal GeneticS

American Genetic Association

Research Interests
Genomics of human and animals
Mouse model of autoimmune diseases
Gene function and evolution


1. Zhang X, Ling Y, Guo Y, Bai Y, Shi X, Gong F, Tan P, Zhang Y, Wei C, He X, Ramirez A, Liu X, Cao C, Zhong H, Xu Q, Ma RZ. (2016) Mps1 kinase regulates tumor cell viability via its novel role in mitochondria. Cell Death Dis. 2016 Jul 7;7(7):e2292. doi: 10.1038/cddis.2016.193.
2. Hou Y, Li Y, Gong F, Jin J, Huang A, Fang Q, Ma RZ. (2016) A Preliminary Study on RCN3 Protein Expression in Non-small Cell Lung Cancer. Clin Lab. 62(3):293-300.
3. Jin J, Li Y, Ren J, Man Lam S, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ. (2016) Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 54(3):410-423. doi: 10.1165/rcmb.2015-0036OC.
4. Zhang X, Pei L, Li R, Zhang W, Yang H, Li Y, Guo Y, Tan P, Han JJ, Zheng X, Ma RZ. (2016) Spina bifida in fetus is associated with an altered pattern of DNA methylation in placenta. J Hum Genet.  60(10):605-611 
5. Jia H, Zhang X, Wang W, Bai Y, Ling Y, Cao C, Ma RZ, Zhong H, Wang X, Xu Q. (2015) A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphase. BMC Cell Biol. 2015 Feb 27;16:6. doi: 10.1186/s12860-015-0048-6.
6. Jung Y, Abdel-Fatah TM, Chan SY, Nolan CC, Green AR, Ellis IO, Li L, Huang B, Lu J, Xu B, Chen L, Ma RZ, Zhang M, Wang J, Wu Z, Zhu T, Perry JK, Lobie PE, Liu DX.(2014)SHON is a novel estrogen-regulated oncogene in mammary carcinoma that predicts patient response to endocrine therapy. Cancer Res. 73(23):6951-6962.
7. Ling Y, Zhang X, Bai Y, Li P, Wei C, Song T, Zheng Z, Guan K, Zhang Y, Zhang B, Liu X, Ma RZ, Cao C, Zhong H, Xu Q. (2014) Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy. Biochem Biophys Res Commun. 450(4):1690-1695.
8. Zhang P, Liu P, Dou H, Chen L, Chen L, Lin L, Tan P, Vajta G, Gao J, Du Y, Ma RZ. (2013) Handmade cloned transgenic sheep rich in omega-3 Fatty acids. PLoS One. 8 (2):e55941. doi: 10.1371.
9. Shi H, Qi X, Zhong H, Peng Y, Zhang X, Ma RZ, Su B. (2013) Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N. PLoS One. 8(6):e66102. doi: 10.1371/ journal.pone.0066102

10. Wang J, Zhu Z, Wang H, Li F, Du X, Ma RZ. (2013) Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs. Int J Oncol. Jun 19. doi: 10.3892/ijo.2013.1987.

11. Zhang X, Ling Y, Wang W, Zhang Y, Ma Q, Tan P, Song T, Wei C, Li P, Liu X, Ma RZ, Zhong H, Cao C, Xu Q. (2013) UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores. Cell Cycle. Apr 15; 12 (8):1292-302. doi: 10.4161/cc.24403.

12. Li G, Liu K, Jiao S, Liu H, Blair HT, Zhang P, Cui X, Tan P, Gao J, Ma RZ. (2012) A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb. BMC Genomics. 16;13(1):398-404.

13. Zhang P, Zhang Y, Dou H, Yin J, Chen Y, Pang X, Vajta G, Bolund L, Du Y, Ma RZ. (2012) Handmade cloned transgenic piglets expressing the nematode fat-1 gene. Cell Reprogram. 14(3):258-266.

14. Wu X, Zhang Y, Chen S, Xu Y, Pei Z, Lin D, Chen Y, Ma RZ. (2012) Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2. BMC Cancer. 28;12(1):192-198.

15. Chen L, Liu K, Zhao Z, Blair HT, Zhang P, Li D, Ma RZ. (2012) Identification of sheep ovary genes potentially associated with off-season reproduction. J Genet Genomics. 39(4):181-190.

16. Zhong H, Li XL, Li M, Hao LX, Chen RW, Xiang K, Qi XB, Ma RZ, Su B. (2011) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population. Arthritis Res Ther. 13 (6): R186.[Epub ahead of print]

17. Zhang X, Yin Q, Ling Y, Zhang Y, Ma RZ, Ma Q, Cao C, Zhong H, Liu X, Xu Q. (2011) Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses. Cell Cycle. 10 (16):2742-50.

18. Zhong H, Shi H, Qi XB, Duan Z, Tan P, Jin L, Su B, Ma RZ. (2011) Extended Y-chromosome investigation suggests post-Glacial migrations of modern humans into East Asia via the northern route. Mol Biol Evol 28(1):717-727.

19. Liu K, Zhang P, Gao J, Liu H, Li G, Qiu Z, Zhang Y, Ren J, Tan P, Ma RZ. (2011) Closing a gap in the physical map of the ovine major histocompatibility complex. Animal Genetics 42(2):204-207.

20. Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma RZ, Su B. (2010) The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history. BMC Evol Biol 10:15-22.

21. Gao J, Liu K, Liu H, Blair HT, Li G, Chen C, Tan P, Ma RZ. (2010) A complete DNA sequence map of the ovine Major Histocompatibility Complex. BMC Genomics. 11(1):466-474.

22. Zhong H, Shi H, Qi XB, Xiao CJ, Jin L, Ma RZ, Su B. (2010) Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia. J Hum Genet. 55(7):428-435.

24. Song J, Zhang X, Qi Z, Sun G, Chi S, Zhu Z, Ren J, Qiu Z, Liu K, Myatt L, Ma RZ. (2009) Cloning and Characterization of a Calcium-Activated Chloride Channel in Rat Uterus. Biol Reprod. 80: 788-794.

25. Shi H, Tan SJ, Zhong H, Hu W, Levine A, Xiao CJ, Peng Y, Qi XB, Shou WH, Ma RL, Li Y, Su B, Lu X. (2009) Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. Am J Hum Genet. 84: 534-541

26. Shi H, Zhong H, Peng Y, Dong YL, Qi XB, Zhang F, Liu LF, Tan SJ, Ma RZ, Xiao CJ, Wells RS, Jin L, Su B. (2008) Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations. BMC Biol. 29, 6:45.

27. Wei H, Ding X, Ren J, Liu K, Tan P, Li D, Ma RZ. (2008) A murine model for human immune thrombocytopenic purpura and comparative analysis of multiple gene expression in bone marrow and spleen. J Genet Genomics. 35(11):665-671.

28. Zhang Y., Dasgupta J., Ma RZ, Banks L., Thomas M., Chen X.S. (2007) Structures of a HPV-E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J. Virology 81:3618-3626.

29. Zhang X., Zhu Z., Huang C., Tan P., Ma RZ (2007) Microsatellite genotyping for four expected inbred mouse strains from KM mice. J Genet Genomics. 34:214-222.

30. Liu HB,Liu K,Wang JF,Ma RZ. (2006) A BAC-based physical map of Ovine Major Histocompatibility Complex (MHC). Genomics, 88:88-95.

31. Szakonyi G, Klein MG, Hannan JP, Young KA, Ma RZ, Asokan R, Holers VM, Chen XS. (2006) Structure of the Epstein-Barr virus major envelope glycoprotein. Nat Struct Mol Biol. 13, 996-1001.

32. Liu YF, Ma RL, Wang SL, Duan ZY, Zhang JH, Wu LJ, Wu CF. (2003) Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli. Protein Expres and Purif. 27(2):253-258.

33. Sun K, Ma RZ, Cui X, Campos B, Webster R, Brockman D, Myatt L. (2003) Glucocorticoids Induce Cytosolic Phospholipase A (2) and Prostaglandin H Synthase Type 2 But Not Microsomal Prostaglandin E Synthase (PGES) and Cytosolic PGES Expression in Cultured Primary Human Amnion Cells. J Clin Endocrinol Metab 88: 5564-5571.

34. Butterfield R.J., Roper R.J., Rhein D.M., Melvold R.W., Haynes L, Ma RZ, Doerge R.W., Teuscher C. (2003) Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler’s Murine Encephalomyelitis Virus-Induced Demyelination. Genetics 163:1041-1046.

35. Ma RZ, Gao J., Meeker N.D., Fillmore P.D., Tung K.S.K., Watanabe T., Blankenhorn E.B. and Teuscher C. (2002) Identification of Bphs, an autoimmune diseases locus, as histamine receptor H1. Science 297:620-623.

36. Roper R.J., Ma, RZ, Biggins, J.E., McAllister, R.D., Min, S., Call, S.B., Butterfield, R.J., Michael S.M., Tung, K.S.K., Doerge, R.W., and Teuscher, C. (2002) Genetic Control of Immunoregulation, Loss of Peripheral Tolerance, and Autoimmune Ovarian Dysgenesis after Day Three Thymectomy in Mice. J Immunol 169:1640-1646.

37. Ambady S, Kappes SM, Park C, Ma RZ, Beever JE, Lewin HA, Smith TP, Beattie CW, Basrur PK, Ponce de Leon FA. (2001) Development and mapping of microsatellites from a microdissected BTA 11-specific DNA library. Animal Genetics 32:152-155.

38. Kim K.I, Yang Y.H, Lee S.S, Park C, Ma RZ, Bouzat J.L, Lewin H.A. (1999) Phylogenetic relationships of Cheju horses to other horse breeds as determined by mtDNA D-loop sequence polymorphism. Animal Genetics 30:102-108.

39. Meeker N.D., A.N. Stafford, J.K. Lunceford, P. Avner, RZ Ma and C. Teuscher. (1999) Physical mapping of the autoimmune disease susceptibility locus, Bphs: Co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6. Mamm Gemone 10:858-863.

40. Teuscher C, Butterfield R.J, Ma RZ, Zachary J.F, Doerge R.W, Blankenhorn E.P. (1999) Sequence polymorphisms in the chemokines scya1 (TCA-3), scya2 (Monocyte chemoattractant protein (MCP)-1), and scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic Remitting/Nonrelapsing experimental allergic encephalomyelitis. J Immunol 163:2262-2266.

41. Da Y, P.M. VanRaden, M. Ron, J.E. Beever, A.A. Paszek, J. Song, G.R. Wiggans, Ma R, J.I. Weller, H.A. Lewin. (1999) Standardization and conversion of marker polymorphism measures. Anim Biotecol 10:25-35.

42. Ma RZ, J.C. Reese and W.C. Black IV. (1999) Chlorophyll loses in the sorghum susceptible to greengubs (Schizaphis graminum). J Kansas Ent Soc 71:51-60.

43. Taylor J.F., A. Eggen, A. Aleyasin, S.M. Armitage, W. Barendse, J.E. Beever, M.D. Bishop, R.A. Brenneman, B.M. Burns, S.K. Davis, K. Elo, B. Harlizius, S.M. Kappes, J.W. Keele, J.S. Kemp, B.W. Kirkpatrick, H.A. Lewin, RZ Ma, R.A.McGraw, D. Pomp, R.T. Stone, Y. Sugimoto, A.J. Teale, D. Vaiman, M.C. Zanotti, et al. (1998) Report of the first workshop on the genetic map of bovine chromosome 1. Animal Genetics 29:228-235.

44. Ma, RZ, M.J.T. van Eijk, J.E. Beever, G. Guèrin, C.L. Mummery, H.A. Lewin. (1998) Comparative analysis of 82 expressed sequence tags from a bovine ovary cDNA library. Mamm Genome 9:545-549.

45. Zhang, A. W., G. L. Hartman, L. Riccioni, W. D. Chen, RZ Ma and Pedersen. (1997) Using PCR to distinguish Diaporthe phaseolorun and Phomopsis longicolla from other soybean fungal pathogens and to detect them in soybean tissues. Plant Disease 81:1143-1149.

46. Ma, RZ, J. E. Beever, Y. DA, C. A. Green, I. Russ, C. Park, D. W. Heyen, R. E. Everts, A. J. Teale, S. J. Kemp, H. C. Hines, G. Guérin and H. A. Lewin. (1996) A male linkage map of the cattle (Bos taurus) genome. J Heredity 87:261-271.

47. Beever, J. E., H. A. Lewin, W. Barendse, L. Andersson, S. M. Armitage, C. W. Beattie, B. M. Burns, S. M. Kappes, B. W. Kirkpatrick, RZ Ma, R. A. McGraw, R. T. Stone and J. F. Taylor. (1996) Report on the first workshop on the genetic map of bovine chromosome 23. Animal Genetics 27:69-75.

48. Ma, RZ, I. Russ, C. Park, D. W. Heyen, J. E. Beever, C. A. Green and H. A. Lewin. (1996) Isolation and characterization of 45 polymorphic microsatellites from the bovine genome. Animal Genetics 27:43-47.

49. Kemp, S. J., O. Hishida, J. Wambugu, A. Rink, RZ Ma, Y. Da, H.A. Lewin, W. Barendse and A. J. Teale. (1995) A panel of bovine, ovine and caprine microsatellites. Animal Genetics 26:299-306.

50. Shalhevet, D., D. Yang, J. E. Beever, M. J. T. van Eijk, R. Ma, H. A. Lewin and H. R. Gaskins. (1995) Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region. Immunogenetics 41:44-46.

51. Ma, R., M. B. Cohen, M. R. Berenbaum and M. A. Schuler. (1994) Black Swallowtail (Papillio polyxenes) alleles encode Cytochrome P-450s that selectively metabolize linear furanocumarins. Arch Biochem Biophysics 310:332-340.

52. Ma, RZ, D. Swedenborg and R. L. Jones. (1992) Host seeking behavior of Eriborus terebrans (Hymenoptera: Ichneumonidae) toward the European corn borer (Ostrinia nubilalis), and the role of chemical stimuli. Ann Ent Soc Amer 85:72-79.

53. Ma, RZ, W. C. Black IV and J. C. Reese. (1992) Genome size and organization in an aphid (Schizaphis graminum). J Insect Physiol 38:161-165.

54. Ma, R, J. C. Reese, W. C. Black IV and P. J. Bramel-Cox. (1990) Detection of pectinesterase and polygalacturonase from salivary secretions of living greenbugs (Schizaphis graminum) (Homoptera: Aphididae). J Insect Physiol. 37:507-512.
Book and Chapters
1. Chen LX, Li RT, and Ma RZ. (2014) Potentials of RNA Aptamers for viral detection and treatment. In RNA Nanotechnology and Therapeutics (Eds. Guo PX & Haque F.) CRC Press Taylor & Francis Group. pp. 449-463.