Zhiheng Xu, M.D., Ph.D.
Key Laboratory of Molecular & Developmental Biology
Institute of Genetics and Developmental Biology
Chinese Academy of Sciences
3 Nan Yi Tiao, Zhongguanchun
Beijing, China
EDUCATION
| 4/1999 |
Ph. D., Department of Microbiology and Molecular Genetics, Waksman Institute, Rutgers University, New Jersey. |
| 7/1989 |
M.D., Department of Medicine, the Second Military Medical University, Shanghai, China. |
RESEARCH EXPERIENCE
| 2004-present: |
Principle investigator, Institute of Genetics and Developmental Biology, Chinese
Academy of Sciences.
Research on apoptosis and neurodegenerative diseases. |
| 2003-2005: |
Associate Scientist, Department of Pathology & Center of Neurobiology and Behavior. Columbia University, New York
Research on apoptosis and neurodegenerative diseases. |
| 1999-2003: |
Postdoctoral research on apoptosis and neurodegenerative diseases
Advisor: Dr. Lloyd A. Greene
Department of Pathology & Center of Neurobiology and Behavior. Columbia University, New York |
| 1993-1999: |
Doctoral research on cell cycle and DNA damage checkpoints, meiosis, and histone acetyl-transferase
Advisor: Dr. David Norris
Waksman Institute
Rutgers University, New Jersey |
| 1989-1993: |
Research on application of memorial steel on spinal injury
Group of Microsurgery, Department of Orthopedics,
Naval Hospital, Shanghai, China |
| |
| AWARDS & HONORS |
| |
Ruth L. Kirschstein National Research Service Award. NIH (2002) |
| |
Bush Fellowship. Waksman Institute, Rutgers University (1997-1999) |
| |
Waksman Fellowship. Waksman Institute, Rutgers University (1993-1997) |
| |
Honor Student. The Second Military Medical University (1984-1989) |
PUBLICATIONS
1.Y Sun, T Fei, T Yang, F Zhang, Y Chen, Z Xu*. The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem.(Accepted)
2.Ren J., Wang Y., Liang Y., Zhang Y., Bao S and Xu Z* (2010) Methylation of ribosomal protein s10 by protein arginine methyltransferase 5 regulates ribosome biogenesis J Biol Chem. (In press)
3.Shen Q, Qin F, Gao Z, Cui J, Xu Z, and Yang C, （2009） Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans. Molecular and Cellular Biology, 29(14): 3881–3893
4.Jin S, Pan L, Liu Z, Wang Q, Xu Z, and Zhang Y (2009) Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation. Development 136(9):1571-81
6.Liu S, Yu M, He Y, Xiao L,…Sun S, and Xu Z* (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47(6) 1964-73
7.Qiao HX, Hao CJ, Li Y, He X, Chen RS, Cui J, Xu Z*, Li W*.（2008） BBRC 370(4):584-8.
8.Liu S， Sun YM et al., (2008) Down-regulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. Bri J Cancer 98(2):363-9
9.Sun Y, Yang T, Xu Z* (2007) The JNK Pathway and Neuronal Migration. J Genetics and Genomics 34(11): 957-965
10.Wilhelm M, Kukekov NV, Xu Z, Greene LA (2007) Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Dev Neurosci. 29(4-5):355-62.
11.Wang L, Zhang Y, Li H, Xu Z, Santella RM, Weinstein IB. (2007) Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells. Cancer Res. 67(10):4700-4708.
12.Cui J, Zhang M, Zhang YQ, Xu Z* (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacol Sin. 28(5):601-8.
13.Welhelm M, Xu Z., and Greene L （2007）Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model. J Biol Chem. 282(2):1288-95.
14.Xu Z.*, Sproul A., Wang WY, and Greene L. (2006) SIAH1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. J Biol Chem. 281(1):303-12. (* Corresponding author)
15.Kukekov, N*.,Xu Z.*, and Greene(2006) Direct interaction of the molecular scaffolds POSH and JIP is required for apoptotic activation of JNKs. J Biol Chem. 281(22):15517-24. (* Equal contribution)
16.Tang G, Xu Z, Goldman JE. (2006) Synergistic effects of the SAPK/JNK & the proteasome pathways on GFAP accumulation in Alexander disease. J Biol Chem. 281(50):38634-43
17.Xu Z.*, Kukekov, N., and Greene L (2005) A stability-based self-amplifying feed forward loop mechanism for regulation of the apoptotic JNK pathway. Mol Cell Biol. 25(22):9949-59. (* Corresponding author)
18.Xu Z.* and Greene L. (2006) Regulation of the apoptotic JNK pathway. Methods Enzymol 406:479-89. (* Corresponding author)
19.Zheng S.*, Xu Z.*¨, and Longey J. (2005) Cbl-b/Cbl regulates c-Kit receptor stability through the proteasomal pathway in mast cells. Blood 105(1):226-32. (* Equal contribution, ¨ Corresponding author).
20.Hanlon SE, Xu Z, Norris DN, Vershon AK. (2004) Analysis of the meiotic role of the mitochondrial ribosomal proteins Mrps17 and Mrpl37 in Saccharomyces cerevisiae. Yeast. 21(15):1241-52.
21.Kim K., Kim B., Xu Z, and Kim S. (2004). Mixed lineage kinase (MLK) 3-activated p38 MAP kinase mediates TGF-Beta-induced apoptosis in hepatoma cells. J Biol Chem. 279(28):29478-84.
22.Xu Z., Kukekov N., and Greene LA (2003). POSH (plenty of SH3’s) Acts as a Scaffold for a Multiprotein Complex that Mediates JNK Activation in Apoptotic Death. EMBO J 15; 22(2): 252-61
23.Xu Z, Maroney AC, Dobrzanski P, Greene LA (2001). The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol Cell Biol. 21(14): 4713-24.
24.Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001). Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem. 276(27): 25302-8.
25.Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001). beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem. 77(1):157-64.
26.Xu Z., and Norris D. (1999). The SFP1 gene product of S. cerevisiae regulates G2/M transitions in the mitotic cell cycle and in response to DNA damage. Genetics 150(4): 1419-28.
|
